23 research outputs found
Lower Blood Calcium Associates with Unfavorable Prognosis and Predicts for Bone Metastasis in NSCLC
Ionized calcium was involved in various cellular signal pathways,and regulates many cellular processes, including those relevant to tumorigenesis. We hypothesis that imbalance of calcium homeostasis is correlated with development of lung carcinomas. We collected the clinical data of 1084 patients with non small cell lung cancer (NSCLC) treated in Shandong Provincial Hospital, Shandong University. Logistic regression was used to determine the association between calcium levels and clinical characteristics, and COX regression and Kaplan-Meier model were applied to analyze risk factors on overall survival. Blood electrolytes were tested before treatment; and nearly 16% patients with NSCLC were complained with decreased blood calcium, which is more frequent than that in other electrolytes. Further, Multivariate logistic regression analysis disclosed that there were significant correlation between blood calcium decrease and moderate and poor differentiation (P = 0.012, OR = 1.926 (1.203–4.219)), squamous cell carcinoma (P = 0.024, OR = 1.968(1.094–3.540)), and bone metastasis (P = 0.032, OR = 0.396(0.235–0.669)). In multivariate COX regression analysis, advanced lymph node stage and decreased blood calcium were significantly and independent, unfavorable prognostic factors (P<0.001). Finally, the Kaplan-Meier Survival curve revealed that blood calcium decrease was associated with shorter survival (Log-rank; χ2 = 26.172,P<0.001). Our finding indicates that lower blood calcium levels are associated with a higher risk of unfavorable prognosis and bone metastasis of NSCLC
Synergies and Prospects for Early Resolution of the Neutrino Mass Ordering
The measurement of neutrino Mass Ordering (MO) is a fundamental element for
the understanding of leptonic flavour sector of the Standard Model of Particle
Physics. Its determination relies on the precise measurement of and using either neutrino vacuum oscillations, such
as the ones studied by medium baseline reactor experiments, or matter effect
modified oscillations such as those manifesting in long-baseline neutrino beams
(LBB) or atmospheric neutrino experiments. Despite existing MO indication
today, a fully resolved MO measurement (5) is most likely to
await for the next generation of neutrino experiments: JUNO, whose stand-alone
sensitivity is 3, or LBB experiments (DUNE and
Hyper-Kamiokande). Upcoming atmospheric neutrino experiments are also expected
to provide precious information. In this work, we study the possible context
for the earliest full MO resolution. A firm resolution is possible even before
2028, exploiting mainly vacuum oscillation, upon the combination of JUNO and
the current generation of LBB experiments (NOvA and T2K). This opportunity
is possible thanks to a powerful synergy boosting the overall sensitivity where
the sub-percent precision of by LBB experiments is found
to be the leading order term for the MO earliest discovery. We also found that
the comparison between matter and vacuum driven oscillation results enables
unique discovery potential for physics beyond the Standard Model.Comment: Entitled in arXiv:2008.11280v1 as "Earliest Resolution to the
Neutrino Mass Ordering?
Robust estimation of bacterial cell count from optical density
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
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Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations
This post hoc analysis of the XIRIUS and XOLARIS studies investigates how changes in visual function associated with cotoretigene toliparvovec gene therapy in participants with
RPGR
-variant X-linked retinitis pigmentosa compare with those of untreated individuals