Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans

Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, \u3e500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases

A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions such as ischemic stroke, brain trauma, and epileptic seizures. Acid-sensing ion channels, or ASICs, are proton-gated cation channels widely expressed in peripheral sensory neurons and in the neurons of the central nervous system. Recent studies have demonstrated that activation of these channels by protons plays an important role in a variety of physiological and pathological processes such as nociception, mechanosensation, synaptic plasticity, and acidosis-mediated neuronal injury. This review provides an overview of the recent advance in electrophysiological, pharmacological characterization of ASICs, and their role in neurological diseases. Therapeutic potential of current available ASIC inhibitors is discussed

The Interplay of Landau Level Broadening and Temperature on Two-Dimensional Electron Systems

This work investigates the influence of low temperature and broadened Landau levels on the thermodynamic properties of two-dimensional electron systems. The interplay between these two physical parameters on the magnetic field dependence of the chemical potential, the specific heat and the magnetization is calculated. In the absence of a complete theory that explains the Landau level broadening, experimental and theoretical studies in literature perform different model calculations of this parameter. Here it is presented that different broadening parameters of Gaussian-shaped Landau levels cause width variations in their contributions to interlevel and intralevel excitations. Below a characteristic temperature, the interlevel excitations become negligible. Likewise, at this temperature range, the effect of the Landau level broadening vanishes.Comment: 5 pages, 5 figures, submitted to Solid State Communication

On the lowest eigenvalue of Laplace operators with mixed boundary conditions

In this paper we consider a Robin-type Laplace operator on bounded domains. We study the dependence of its lowest eigenvalue on the boundary conditions and its asymptotic behavior in shrinking and expanding domains. For convex domains we establish two-sided estimates on the lowest eigenvalues in terms of the inradius and of the boundary conditions

The Large Magellanic Cloud: A power spectral analysis of Spitzer images

We present a power spectral analysis of Spitzer images of the Large Magellanic Cloud. The power spectra of the FIR emission show two different power laws. At larger scales (kpc) the slope is ~ -1.6, while at smaller ones (tens to few hundreds of parsecs) the slope is steeper, with a value ~ -2.9. The break occurs at a scale around 100-200 pc. We interpret this break as the scale height of the dust disk of the LMC. We perform high resolution simulations with and without stellar feedback. Our AMR hydrodynamic simulations of model galaxies using the LMC mass and rotation curve, confirm that they have similar two-component power-laws for projected density and that the break does indeed occur at the disk thickness. Power spectral analysis of velocities betrays a single power law for in-plane components. The vertical component of the velocity shows a flat behavior for large structures and a power law similar to the in-plane velocities at small scales. The motions are highly anisotropic at large scales, with in-plane velocities being much more important than vertical ones. In contrast, at small scales, the motions become more isotropic.Comment: 8 pages, 4 figures, talk presented at "Galaxies and their Masks", celebrating Ken Freeman's 70-th birthday, Sossusvlei, Namibia, April 2010. To be published by Springer, New York, editors D.L. Block, K.C. Freeman, & I. Puerar

The impact of analyst sentiment on UK stock recommendations and target prices

© 2015 Taylor & Francis. The aim of this paper is to investigate the relationship between narrative sentiment in analysts' company reports and their recommendation and target price outputs. We study an industry-balanced sample of 275 UK quoted company sell-side analyst reports over the period 2006-2010 using a content analysis methodology to measure net sentiment for a range of themes. We then model analysts' outputs against themed sentiment scores to analyse the impact of the Global Financial Crisis. We find that themed sentiments impact upon analysts' outputs, but their magnitude and direction vary over the pre-crisis, crisis and post-crisis periods. In particular, before the crisis we find a strong negative relationship between the macroeconomic and regulatory environment and report outputs, though this effect diminishes somewhat with the onset of the crisis, to be restored thereafter. Growth sentiment exerts a weak positive impact before the crisis which disappears thereafter. Financial performance sentiment becomes a significant positive driver of outputs following the crisis. There is evidently a "back to basics" approach following the crisis which restores financial fundamentals to the heart of stock analysis. Our findings provide some insight into the thought processes of analysts by identifying the dynamic relation between analysts' outputs and themed sentiments

The evolution of cosmic string loops in Kerr-de Sitter spacetimes

The equation of cosmic string loops in Kerr-de Sitter spacetimes is derived. Having solved the equation numerically, we find that the loops can expand and exist except for too small ones.Comment: 8 page

Effect of Boron substitution on the superconductivity of non-oxide perovskite MgCNi3

We report synthesis, structural and magnetic (DC and AC) properties of Boron substituted MgCNi3 superconductor. A series of polycrystalline bulk samples Mg1.2C1.6-xBxNi3 (x = 0.0, 0.08 and 0.16) is synthesized through standard solid-state reaction route, which are found to crystallize in cubic perovskite structure with space group Pm3m. Rietveld analysis of observed XRD data show that lattice parameters expand from a = 3.8106 (4) {\AA} for pure, to 3.8164 (2) {\AA} and 3.8173 (5) {\AA} for 5% and 10% Boron substituted samples respectively. DC magnetization exhibited superconducting transition (Tc) at around 7.3 K for pure sample, and the same decreases slightly with Boron substitution. The lower critical field (Hc1) at 2 K is around 150 Oe for pure sample, which increases slightly with Boron substitution. For pure sample the upper critical field (Hc2) being determined from AC susceptibility measurements is 11.6 kOe and 91.70 kOe with 50% and 90% diamagnetism criteria respectively, which decreases to 5.57 kOe and 42.5 kOe respectively for 10% Boron substituted sample. 10% Boron substitution at Carbon site has decreased both the Hc2 and Tc. On the other hand lower critical field (Hc1) at 2 K is slightly increased from around 150 Oe for pure sample, to 200 Oe for 10% Boron substituted sample. Seemingly, the Carbon site Boron substitution induced disorder though has increased slightly the Hc1 but with simultaneous decrease in superconducting transition temperature (Tc) and upper critical field (Hc2). The high relative proportion of Ni in studied MgCNi3 suggests that magnetic interactions are important and non-oxide perovskite structure make it interesting.Comment: 13 Pages Text + Figures: comments/suggestions ([email protected]

Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery and retroperitoneum) and are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). EGISTs arising in the retroperitoneum are extremely rare: to date, only 58 cases have been reported in the literature. Case Report We herein report a case of a primary EGIST of the retroperitoneum surgically treated. The pre-operative radiological evaluation showed a retroperitoneal mass, placed in left paravertebral region. Results Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor (intermediate-low risk form). Conclusions As a result of the rarity of reports of primary EGISTs of retroperitoneum we need to analyze the data of reported cases in order to gain a better understanding about the pathogenesis, prognosis and optimal treatment of this disease

Curve counting via stable pairs in the derived category

For a nonsingular projective 3-fold $X$, we define integer invariants virtually enumerating pairs $(C,D)$ where $C\subset X$ is an embedded curve and $D\subset C$ is a divisor. A virtual class is constructed on the associated moduli space by viewing a pair as an object in the derived category of $X$. The resulting invariants are conjecturally equivalent, after universal transformations, to both the Gromov-Witten and DT theories of $X$. For Calabi-Yau 3-folds, the latter equivalence should be viewed as a wall-crossing formula in the derived category. Several calculations of the new invariants are carried out. In the Fano case, the local contributions of nonsingular embedded curves are found. In the local toric Calabi-Yau case, a completely new form of the topological vertex is described. The virtual enumeration of pairs is closely related to the geometry underlying the BPS state counts of Gopakumar and Vafa. We prove that our integrality predictions for Gromov-Witten invariants agree with the BPS integrality. Conversely, the BPS geometry imposes strong conditions on the enumeration of pairs.Comment: Corrected typos and duality error in Proposition 4.6. 47 page