DQ impedance stability analysis for the power-controlled grid-connected inverter

For a grid-connected inverter requiring the ac volt- age magnitude and the active power control, both vector control and power synchronization control can be applied. The stability comparison based on the dq impedance stability analysis between both control are carried out via three factors including the grid impedance, the inner current loop and the virtual impedance. The dq impedances of the inverter based on both control are derived. The determinant of the impedance ratio is used for the stability analysis. The bode plot of the grid impedance and the inverter impedance are present to assist the stability analysis and explain their interactions. It is found that increasing the grid impedance and the cut-off frequency of the current loop stabilize the inverter with the power synchronization control, which is converse to the vector control. Furthermore, the inverter with the power synchronization control may suffer the instabilities when connecting to a strong grid. The virtual inductor and resistor are proposed to enhance the stability for the vector control and the power synchronization control respectively. The simulation validation using Matlab/Simulink is performed

Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials

Aims/hypothesis By analysing available evidence from randomised controlled trials (RCTs), we aimed to examine whether and to what extent sodium–glucose cotransporter 2 (SGLT2) inhibitors affect serum electrolyte levels in type 2 diabetes patients. Methods We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov up to 24 May 2016 for published RCTs of SGLT2 inhibitors that reported changes in serum electrolyte levels. Weighted mean differences (WMD) between each SGLT2 inhibitor and placebo were calculated using a random-effects model. Dose-dependent relationships for each SGLT2 inhibitor were evaluated using meta-regression analysis. Results Eighteen eligible RCTs, including 15,309 patients and four SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin and ipragliflozin) were evaluated. In patients without chronic kidney disease, each SGLT2 inhibitor significantly increased serum magnesium levels compared with placebo (canagliflozin: WMD 0.06 mmol/l for 100 mg and 0.09 mmol/l for 300 mg; dapagliflozin: WMD 0.1 mmol/l for 10 mg; empagliflozin: WMD 0.04 mmol/l for 10 mg and 0.07 mmol/l for 25 mg; and ipragliflozin: WMD 0.05 mmol/l for 50 mg). Canagliflozin increased serum magnesium in a linear dose-dependent manner (p = 0.10). Serum phosphate was significantly increased by dapagliflozin. Serum sodium appeared to significantly differ by SGLT2 inhibitor type. No significant changes in serum calcium and potassium were observed. Findings were robust after including trials involving patients with chronic kidney disease. Conclusions/interpretation SGLT2 inhibitors marginally increased serum magnesium levels in type 2 diabetes patients indicating a drug class effect. Further investigations are required to examine the clinical significance of elevated magnesium levels in individuals with type 2 diabetes

Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials

The antihypertensive effect of magnesium (Mg) supplementation remains controversial. We aimed to quantify the effect of oral Mg supplementation on blood pressure (BP) by synthesizing available evidence from randomized, double-blind, placebo-controlled trials. We searched trials of Mg supplementation on normotensive and hypertensive adults published up to February 1, 2016 from MEDLINE and EMBASE databases; 34 trials involving 2028 participants were eligible for this meta-analysis. Weighted mean differences of changes in BP and serum Mg were calculated by random-effects meta-analysis. Mg supplementation at a median dose of 368 mg/d for a median duration of 3 months significantly reduced systolic BP by 2.00 mm Hg (95% confidence interval, 0.43–3.58) and diastolic BP by 1.78 mm Hg (95% confidence interval, 0.73–2.82); these reductions were accompanied by 0.05 mmol/L (95% confidence interval, 0.03, 0.07) elevation of serum Mg compared with placebo. Using a restricted cubic spline curve, we found that Mg supplementation with a dose of 300 mg/d or duration of 1 month is sufficient to elevate serum Mg and reduce BP; and serum Mg was negatively associated with diastolic BP but not systolic BP (all P<0.05). In the stratified analyses, a greater reduction in BP tended to be found in trials with high quality or low dropout rate (all P values for interaction <0.05). However, residual heterogeneity may still exist after considering these possible factors. Our findings indicate a causal effect of Mg supplementation on lowering BPs in adults. Further well-designed trials are warranted to validate the BP-lowering efficacy of optimal Mg treatment

Improved grid impedance compensation for phase-locked loop to stabilize the very-weak-grid connection of VSI's

Voltage source inverters (VSIs) with vector control based on phase-locked loop (PLL) suffer instability when connecting to a very weak AC grid (short circuit ratio (SCR)<1.3). The conventional grid impedance compensation for the PLL by virtually reducing the grid impedance can stabilize this connection. However, the analysis in this paper indicates that its stabilization effectiveness is sensitive to grid impedance variance and, indeed, overcompensation causes the PLL instability. Therefore, in this paper, an improved grid impedance compensation for the PLL is proposed to achieve the same stabilization for very-weak-grid connection and possess a good tolerance of grid impedance variance and overcompensation. A comprehensive Small-signal model of the VSI using the proposed PLLs grid impedance compensation is derived for stability analysis and parameter design. The time-domain simulation for this VSI is built to validate the stability analysis. Comparison studies for both proposed and conventional PLLs grid impedance compensation are conducted including the stability effectiveness, VSI performance and grid impedance variance

Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans

The hippocampus has been widely studied using neuroimaging, as it plays an important role in memory and learning. However, hippocampal subfield information is difficult to capture by standard magnetic resonance imaging (MRI) techniques. To facilitate morphometric study of hippocampal subfields, ADNI introduced a high resolution (0.4 mm in plane) T2-weighted turbo spin-echo sequence that requires 8 min. With acceleration, the protocol can be acquired in 4 min. We performed a comparative study of hippocampal subfield volumes using standard and accelerated protocols on a Siemens Prisma 3T MRI in an independent sample of older adults that included 10 cognitively normal controls, 9 individuals with subjective cognitive decline, 10 with mild cognitive impairment, and 6 with a clinical diagnosis of Alzheimer’s disease (AD). The Automatic Segmentation of Hippocampal Subfields (ASHS) software was used to segment 9 primary labeled regions including hippocampal subfields and neighboring cortical regions. Intraclass correlation coefficients were computed for reliability tests between 4 and 8 min scans within and across the four groups. Pairwise group analyses were performed, covaried for age, sex and total intracranial volume, to determine whether the patterns of group differences were similar using 4 vs. 8 min scans. The 4 and 8 min protocols, analyzed by ASHS segmentation, yielded similar volumetric estimates for hippocampal subfields as well as comparable patterns of differences between study groups. The accelerated protocol can provide reliable imaging data for investigation of hippocampal subfields in AD-related MRI studies and the decreased scan time may result in less vulnerability to motion

Hand-drawn resistors, capacitors, diodes, and circuits for a pressure sensor system on paper

Hand-written fabrication techniques offer new ways of developing customizable, biodegradable and low-cost electronic systems. In this work, a new level of complexity is demonstrated for hand-written electronics by fabricating passive components, circuits and a sensorsystem on paper. The system comprises a pencil-written graphite force-sensitive-resistor, a pencil-drawn RC-filter, a pen-written half-wave rectifier, and a commercial front-end voltage amplifier. The sensor system exhibits a linear response for pressures up to 1.2 kPa, and a sensitivity of 51 mV kPa-1 . Furthermore, the electrical and mechanical performance of the single components and circuits is studied. Diodes fabricated through pen-written deposition of silver and nickel contacts on amorphous Indium-Gallium-Zinc-Oxide coated paper show rectification ratios up to 1:8. Tensile and compressive bending measurements applied to all pencil-written components for radii down to 0.1 mm indicate minor influence of strain. Similar results are obtained for circuits created from these individual components. Diodes and half-wave rectifiers show a stable behavior when bent to a radius of 5 mm. The presented techniques can enable the development of flexible and eco-friendly wearables and sensors for consumer and healthcare applications, and are an effective way for school-pupils to explore the world of electronics

Economic viability of dynamic wireless charging technology for private EVs

Dynamic wireless charging (DWC), which enables charging while EVs are in motion, is an attractive charging way. However, additional installed power tracks underneath the lane bring a significant concern on its economic viability. This paper proposes a comprehensive framework to evaluate the economic viability of the DWC lane for private EVs. The investment of local power support with renewable energy integration and energy storage is also considered in the DWC system. Charging choices of private EVs among multiple charging providers are modelled to estimate the electricity demand of the DWC system. The grid impact of the DWC system is studied via a multi-bus AC network. Moreover, an optimization policy is proposed to maximize the DWC provider’s profit and minimize the grid impact by adjusting the charging price and electricity procurement at each horizon. It is found that the payback period of the DWC system with the proposed optimization policy is shortened by 25% compared with the fixed charging price strategy. Even with a tight grid impact limit, the payback period will not be significantly longer under the proposed optimization policy. When the efficiency of the DWC lane increases to 90% and the cost reduces to 50%, the payback period is shortened by 19% and 22%, respectively

Practical computational toolkits for dendrimers and dendrons structure design

Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures. Herein we describe two novel graphical user interface (GUI) toolkits written in Python that provide an improved degree of automation for rapid assembly of dendrimers and generation of their 2D and 3D structures. Our first toolkit uses the RDkit library, SMILES nomenclature of monomers and SMARTS reaction nomenclature to generate SMILES and mol files of dendrimers without 3D coordinates. These files are used for simple graphical representations and storing their structures in databases. The second toolkit assembles complex topology dendrimers from monomers to construct 3D dendrimer structures to be used as starting points for simulation using existing and widely available software and force fields. Both tools were validated for ease-of-use to prototype dendrimer structure and the second toolkit was especially relevant for dendrimers of high complexity and size.Peer reviewe

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damageand impaired immunity. These constraints make it difficult to define the relevance of necroptosis in diseases such as chronic andpersistent viral infections and within individual organ systems. The role of necroptotic signalling is further complicated becauseproteins essential to this pathway, such as receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like(MLKL), have been implicated in roles outside of necroptotic signalling. We sought to address this issue by individually defining therole of RIPK3 and MLKL in chronic lymphocytic choriomeningitis virus (LCMV) infection. We investigated if necroptosis contributesto the death of LCMV-specific CD8+ T cells or virally infected target cells during infection. We provide evidence showing thatnecroptosis was redundant in the pathogenesis of acute forms of LCMV (Armstrong strain) and the early stages of chronic (Docilestrain) LCMV infection in vivo. The number of immune cells, their specificity and reactivity towards viral antigens and viral loads arenot altered in the absence of either MLKL or RIPK3 during acute and during the early stages of chronic LCMV infection. However, weidentified that RIPK3 promotes immune dysfunction and prevents control of infection at later stages of chronic LCMV disease. Thiswas not phenocopied by the loss of MLKL indicating that the phenotype was driven by a necroptosis-independent function ofRIPK3. We provide evidence that RIPK3 signaling evoked a dysregulated type 1 interferone response which we linked to animpaired antiviral immune response and abrogated clearance of chronic LCMV infectio