355 research outputs found
Methods and protocols for incremental exercise testing in tetraplegia, using arm-crank ergometry assisted by Functional Electrical Stimulation
Cervical spinal cord injury (SCI) leads to tetraplegia, with paralysis and loss of sensation in the upper and lower limbs. The associated sedentary lifestyle results in an increased risk of cardiovascular disease. To address this, we require the design of exercise modalities aimed
specifically at tetraplegia and methods to assess their efficacy.
This paper describes methods for arm-crank ergometry (ACE) assisted by Functional Electrical Stimulation (FES) applied to the biceps and triceps. The instrumented ergometer
enables work-rate control during exercise, implemented here for incremental exercise testing during FES-ACE. Detailed protocols for the tests are given.
Experimental data collected during exercise tests with tetraplegic volunteers are provided to illustrate the feasibility of the proposed approach to testing and data analysis. Incremental tests enabled calculation of peak power output and peak oxygen uptake.
We propose that the high-precision exercise testing protocols described here are appropriate to assess the efficacy of the novel exercise modality, FES-ACE, in tetraplegia
Improving open and rigorous science: Ten key future research opportunities related to rigor, reproducibility, and transparency in scientific research
Background: As part of a coordinated effort to expand research activity around rigor, reproducibility, and transparency (RRT) across scientific disciplines, a team of investigators at the Indiana University School of Public Health-Bloomington hosted a workshop in October 2019 with international leaders to discuss key opportunities for RRT research. Objective: The workshop aimed to identify research priorities and opportunities related to RRT. Design: Over two-days, workshop attendees gave presentations and participated in three working groups: (1) Improving Education & Training in RRT, (2) Reducing Statistical Errors and Increasing Analytic Transparency, and (3) Looking Outward: Increasing Truthfulness and Accuracy of Research Communications. Following small-group discussions, the working groups presented their findings, and participants discussed the research opportunities identified. The investigators compiled a list of research priorities, which were circulated to all participants for feedback. Results: Participants identified the following priority research questions: (1) Can RRT-focused statistics and mathematical modeling courses improve statistics practice?; (2) Can specialized training in scientific writing improve transparency?; (3) Does modality (e.g. face to face, online) affect the efficacy RRT-related education?; (4) How can automated programs help identify errors more efficiently?; (5) What is the prevalence and impact of errors in scientific publications (e.g., analytic inconsistencies, statistical errors, and other objective errors)?; (6) Do error prevention workflows reduce errors?; (7) How do we encourage post-publication error correction?; (8) How does 'spin' in research communication affect stakeholder understanding and use of research evidence?; (9) Do tools to aid writing research reports increase comprehensiveness and clarity of research reports?; and (10) Is it possible to inculcate scientific values and norms related to truthful, rigorous, accurate, and comprehensive scientific reporting? Conclusion: Participants identified important and relatively unexplored questions related to improving RRT. This list may be useful to the scientific community and investigators seeking to advance meta-science (i.e. research on research)
Spin-Charge Separation in the Model: Magnetic and Transport Anomalies
A real spin-charge separation scheme is found based on a saddle-point state
of the model. In the one-dimensional (1D) case, such a saddle-point
reproduces the correct asymptotic correlations at the strong-coupling
fixed-point of the model. In the two-dimensional (2D) case, the transverse
gauge field confining spinon and holon is shown to be gapped at {\em finite
doping} so that a spin-charge deconfinement is obtained for its first time in
2D. The gap in the gauge fluctuation disappears at half-filling limit, where a
long-range antiferromagnetic order is recovered at zero temperature and spinons
become confined. The most interesting features of spin dynamics and transport
are exhibited at finite doping where exotic {\em residual} couplings between
spin and charge degrees of freedom lead to systematic anomalies with regard to
a Fermi-liquid system. In spin dynamics, a commensurate antiferromagnetic
fluctuation with a small, doping-dependent energy scale is found, which is
characterized in momentum space by a Gaussian peak at (, ) with
a doping-dependent width (, is the doping
concentration). This commensurate magnetic fluctuation contributes a
non-Korringa behavior for the NMR spin-lattice relaxation rate. There also
exits a characteristic temperature scale below which a pseudogap behavior
appears in the spin dynamics. Furthermore, an incommensurate magnetic
fluctuation is also obtained at a {\em finite} energy regime. In transport, a
strong short-range phase interference leads to an effective holon Lagrangian
which can give rise to a series of interesting phenomena including linear-
resistivity and Hall-angle. We discuss the striking similarities of these
theoretical features with those found in the high- cuprates and give aComment: 70 pages, RevTex, hard copies of 7 figures available upon request;
minor revisions in the text and references have been made; To be published in
July 1 issue of Phys. Rev. B52, (1995
Current Fluctuations and Electron-Electron Interactions in Coherent Conductors
We analyze current fluctuations in mesoscopic coherent conductors in the
presence of electron-electron interactions. In a wide range of parameters we
obtain explicit universal dependencies of the current noise on temperature,
voltage and frequency. We demonstrate that Coulomb interaction decreases the
Nyquist noise. In this case the interaction correction to the noise spectrum is
governed by the combination , where is the transmission
of the -th conducting mode. The effect of electron-electron interactions on
the shot noise is more complicated. At sufficiently large voltages we recover
two different interaction corrections entering with opposite signs. The net
result is proportional to , i.e. Coulomb interaction
decreases the shot noise at low transmissions and increases it at high
transmissions.Comment: 16 pages, 2 figure
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Observation of hard scattering in photoproduction events with a large rapidity gap at HERA
Events with a large rapidity gap and total transverse energy greater than 5
GeV have been observed in quasi-real photoproduction at HERA with the ZEUS
detector. The distribution of these events as a function of the
centre of mass energy is consistent with diffractive scattering. For total
transverse energies above 12 GeV, the hadronic final states show predominantly
a two-jet structure with each jet having a transverse energy greater than 4
GeV. For the two-jet events, little energy flow is found outside the jets. This
observation is consistent with the hard scattering of a quasi-real photon with
a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Statistical Outliers and Dragon-Kings as Bose-Condensed Droplets
A theory of exceptional extreme events, characterized by their abnormal sizes
compared with the rest of the distribution, is presented. Such outliers, called
"dragon-kings", have been reported in the distribution of financial drawdowns,
city-size distributions (e.g., Paris in France and London in the UK), in
material failure, epileptic seizure intensities, and other systems. Within our
theory, the large outliers are interpreted as droplets of Bose-Einstein
condensate: the appearance of outliers is a natural consequence of the
occurrence of Bose-Einstein condensation controlled by the relative degree of
attraction, or utility, of the largest entities. For large populations, Zipf's
law is recovered (except for the dragon-king outliers). The theory thus
provides a parsimonious description of the possible coexistence of a power law
distribution of event sizes (Zipf's law) and dragon-king outliers.Comment: Latex file, 16 pages, 1 figur
Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood (vol 6, 92, 2021)
Genetics of disease, diagnosis and treatmen
- …