225 research outputs found
Chemically driven switches for online detection of pH changes in microfluidic devices
The internal walls of microfabricated fluidic channels were functionalized with a selfassembled monolayer of Rhodamine B lactam. This molecule has the capability to interconvert between its open fluorescent amide form and the closed non-fluorescent lactam form upon changes of the pH conditions. The interconversion (switch) between the two reversible forms is achieved by addition of an acid or a base and is consistent with a reaction mechanism of the first order. This paper describes the online observation of such fluorescent switch covalently anchored to the channel and proposes this method as a possible sensor for the monitoring of pH changes in microreactors
Duality properties of Gorringe-Leach equations
In the category of motions preserving the angular momentum's direction,
Gorringe and Leach exhibited two classes of differential equations having
elliptical orbits. After enlarging slightly these classes, we show that they
are related by a duality correspondence of the Arnold-Vassiliev type. The
specific associated conserved quantities (Laplace-Runge-Lenz vector and
Fradkin-Jauch-Hill tensor) are then dual reflections one of the othe
Holographic mesons in various dimensions
We calculate the spectrum of fluctuations of a probe Dk-brane in the
background of N Dp-branes, for k=p,p+2,p+4 and p< 5. The result corresponds to
the mesonic spectrum of a (p+1)-dimensional super-Yang-Mills (SYM) theory
coupled to `dynamical quarks', i.e., fields in the fundamental representation
-- the latter are confined to a defect for k=p and p+2. We find a universal
behaviour where the spectrum is discrete and the mesons are deeply bound. The
mass gap and spectrum are set by the scale M ~ m_q/g_{eff}(m_q), where m_q is
the mass of the fundamental fields and g_{eff}(m_q) is the effective coupling
evaluated at the quark mass, i.e. g_{eff}^2(m_q)=g_{ym}^2 N m_q^{p-3}. We
consider the evolution of the meson spectra into the far infrared of
three-dimensional SYM, where the gravity dual lifts to M-theory. We also argue
that the mass scale appearing in the meson spectra is dictated by holography.Comment: 44 pages, 2 figures; v2: typos corrected, references adde
Open string modes at brane intersections
We study systematically the open string modes of a general class of BPS
intersections of branes. We work in the approximation in which one of the
branes is considered as a probe embedded in the near-horizon geometry generated
by the other type of branes. We mostly concentrate on the D3-D5 and D3-D3
intersections, which are dual to defect theories with a massive hypermultiplet
confined to the defect. In these cases we are able to obtain analytical
expressions for the fluctuation modes of the probe and to compute the
corresponding mass spectra of the dual operators in closed form. Other BPS
intersections are also studied and their fluctuation modes and spectra are
found numerically.Comment: 58 pages, 3 figures, LaTeX;v2: typos correcte
Berry phases and pairing symmetry in Holstein-Hubbard polaron systems
We study the tunneling dynamics of dopant-induced hole polarons which are
self-localized by electron-phonon coupling in a two-dimensional antiferro-
magnet. Our treatment is based on a path integral formulation of the adia-
batic approximation, combined with many-body tight-binding, instanton, con-
strained lattice dynamics, and many-body exact diagonalization techniques. Our
results are mainly based on the Holstein- and, for comparison, on the
Holstein-Hubbard model. We also study effects of 2nd neighbor hopping and
long-range electron-electron Coulomb repulsion. The polaron tunneling dynamics
is mapped onto an effective low-energy Hamiltonian which takes the form of a
fermion tight-binding model with occupancy dependent, predominant- ly 2nd and
3rd neighbor tunneling matrix elements, excluded double occupan- cy, and an
effective intersite charge interactions. Antiferromagnetic spin correlations in
the original many-electron Hamiltonian are reflected by an attractive
contribution to the 1st neighbor charge interaction and by Berry phase factors
which determine the signs of effective polaron tunneling ma- trix elements. In
the two-polaron case, these phase factors lead to polaron pair wave functions
of either -wave symmetry or p-wave symme- try with zero and
nonzero total pair momentum, respectively. Implications for the doping
dependent isotope effect, pseudo-gap and Tc of a superconduc- ting polaron pair
condensate are discussed/compared to observed in cuprates.Comment: 23 pages, revtex, 13 ps figure
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Cost-based filtering for stochastic inventory control
Abstract. An interesting class of production/inventory control problems considers a single product and a single stocking location, given a stochastic demand with a known non-stationary probability distribution. Under a widely-used control policy for this type of inventory system, the objective is to find the optimal number of replenishments, their timings and their respective order-up-to-levels that meet customer demands to a required service level. We extend a known CP approach for this problem using a cost-based filtering method. Our algorithm can solve to optimality instances of realistic size much more efficiently than previous approaches, often with no search effort at all.
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA
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