5 research outputs found

    Slaves, Soldiers, Citizens: African American Artifacts of the Civil War Era

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    Based on the exhibit Slaves, Soldiers, Citizens: African American Artifacts of the Civil War Era, this book provides the full experience of the exhibit, which was on display in Special Collections at Musselman Library November 2012- December 2013. It also includes several student essays based on specific artifacts that were part of the exhibit. Table of Contents: Introduction Angelo Scarlato, Lauren Roedner ’13 & Scott Hancock Slave Collars & Runaways: Punishment for Rebellious Slaves Jordan Cinderich ’14 Chancery Sale Poster & Auctioneer’s Coin: The Lucrative Business of Slavery Tricia Runzel ’13 Isaac J. Winters: An African American Soldier from Pennsylvania Who Fought at Petersburg Avery Lentz ’14 Basil Biggs: A Prominent African American in Gettysburg after the Battle Lauren Roedner ’13 Linton Ingram: A Former Slave Who Became a Notable African American Educator in Georgia Brian Johnson & Lincoln Fitch ’14 Uncle Tom’s Cabin Theatre Poster: Racism in Post-Emancipation Entertainment Michelle Seabrook ’13 Essay Bibliographies Grand Army of the Republic Exhibit Inventory Acknowledgmentshttps://cupola.gettysburg.edu/libexhibits/1001/thumbnail.jp

    Intra-rater reliability, measurement precision, and inter-test correlations of 1RM single-leg leg-press, knee-flexion, and knee-extension in uninjured adult agility-sport athletes: Considerations for right and left unilateral measurements in knee injury control

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    Objectives Knowledge of single-leg knee strength test reliability for the right and left limb is critical for between-limb clinical decision-making. Knowledge of between-test correlations is essential for understanding whether tests measure similar or different aspects of muscle strength. This study investigated the intra-rater, test-retest reliability and measurement precision of one repetition maximum (1RM) single-leg leg-press (LP), knee-flexion (KF), and knee-extension (KE) for both limbs, and inter-test correlations. Design Repeated measures; Setting University. Participants Six males, seven females (age 25.6±5.5yr; height 171.4±8.4cm; mass 71.8±13.4kg). Main outcome measures Normalised 1RM (percent body-mass (%BM)), intraclass correlation coefficient (ICC) (Avery, 1995; Rivara, 2003), standard error of measurement (SEM; %BM), Pearson's correlation (r), coefficient of determination (r2). Results Mean 1RM test-retest values were (right, left): LP, 214.2–218.5%BM, 213.5–215.4%BM; KF, 35.9–38.9%BM, 37.7–38.2%BM; KE, 43.3–44.6%BM, 36.2–39.3%BM. The ICCs/SEMs were (right, left): LP, 0.98/7.3%BM, 0.94/14.2%BM; KF, 0.75/4.9%BM, 0.95/1.9%BM; KE, 0.87/3.4%BM, 0.78/4.4%BM. Correlations were significant (P < 0.01), r/r2 values were: LP-KF, 0.60/0.36; LP-KE, 0.59/0.35; KF-KE, 0.50/0.25. Conclusions Tests demonstrated good reliability and measurement precision, although ICCs and SEMs were different between limbs. Tests were correlated, but only one-third of the variance was shared between tests. Practitioners should be cognisant of between-limb differences in reliability and include all tests for knee clinical decision-making

    Edoxaban versus warfarin in patients with atrial fibrillation

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    Contains fulltext : 125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)

    Telomere Biology and Biochemistry

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