2,614 research outputs found
Management of lymphoma survivor patients in Italy: an evaluation by Fondazione Italiana Linfomi
Several outpatient models for the follow-up of cancer survivors have been developed worldwide. A multidisciplinary approach is often necessary to guarantee the best monitoring of long-term toxicities. Guidelines also indicate a close education on healthy lifestyles. In this context, we have analyzed the Italian follow-up modalities of lymphoma survivors, with the aim to have a starting line to hypothesize and plan the best model for Italian hematology centers
Sex Influence on Fenestrated and Branched Endovascular Aortic Aneurysm Repair: Outcomes From a National Multicenter Registry
Introduction: Women are generally underrepresented in trials focusing on aortic aneurysm. Nevertheless, sex-related differences have recently emerged from several studies and registries. The aim of this research was to assess whether sex-related anatomical disparities existed in fenestrated and branched aortic repair candidates and whether these discrepancies could influence endovascular repair outcomes. Methods: Data from all consecutive patients treated during the 2008â2019 period within the Italian Multicenter fenestrated or branched endovascular aortic repair (F/BEVAR) Registry were included in the present study. Propensity matching was performed using a logistic regression model adjusted for demographic data and comorbidities to obtain comparable male and female samples. The selection model led to a final study population of 176 patients (88 women and 88 men) among the total initial cohort of 596. Study endpoints were technical and clinical success, overall survival, aneurysm-related death, and reintervention rates evaluated at 30 days and during follow-up. Results: Twenty-eight patients (15.9%) received urgent/emergent repair. In most of the cases (71.6%), women received treatment for extensive thoracoabdominal pathology (Crawford type I, II, or III aneurysm rather than type IV or juxta-pararenal) versus 46.6% of men (p=0.001). Female patients presented with more challenging iliac accesses with at least one side considered hostile in 27.3% of the cases (vs 13.6% in male patients, p=0.039). Finally, women had significantly smaller visceral vessels. Women had significantly worse operative outcomes, with an 86.2% technical success rate versus 96.6% in the male population (p=0.016). No differences were recorded in terms of 30-day reinterventions between men and women. The 5-year estimate of freedom from late reintervention, according to Kaplan-Meier analysis, was 85.6% in men versus 81.6% in women (p=ns). No aneurysm-related death was recorded during follow-up (median observational time, 23 months [interquartile range, 7â45 months]). Conclusion: Women presented a significantly higher incidence of thoracoabdominal aneurysms, smaller visceral vessels, and more complex iliofemoral accesses, resulting in a significantly lower technical success after F/BEVAR. Further studies assessing sex-related differences are needed to properly determine the impact on outcomes and stratify procedural risks. Clinical Impact: Women are generally underrepresented in trials focusing on aortic aneurysms. Aiming to assess whether sex may affect outcomes after a complex endovascular aortic repair, a propensity score selection was applied to a total population of 596 patients receiving F/BEVAR aortic repair with the Cook platform, matching each treated female patient with a corresponding male patient. Women presented more frequently a thoracoabdominal aneurysm extent, smaller visceral vessels, and complex iliofemoral accesses, resulting in significantly worse operative outcomes, with an 86.2% technical success versus 96.6% (p=0.016). No differences were recorded in terms of short-term and mid-term reinterventions. According to these results, careful and critical assessment should be posed in case of female patients receiving complex aortic repair, especially regarding preoperative anatomical evaluation and clinical selection with appropriate surgical risk stratification
A Laser Based Instrument for MWPC Wire Tension Measurement
A fast and simple method for the measurement of the mechanical tension of wires of Multi Wires Proportional Chambers (MWPCs) is described. The system is based on commercial components and does not require any electrical connection to the wires or electric or magnetic field. It has been developed for the quality control of MWPCs of the Muon Detector of the LHCb experiment in construction at CERN. The system allows a measurement of the wire tension with a precision better than 0.5% within 3-4 seconds per wir
Performance of ALICE pixel prototypes in high energy beams
The two innermost layers of the ALICE inner tracking system are instrumented
with silicon pixel detectors. Single chip assembly prototypes of the ALICE
pixels have been tested in high energy particle beams at the CERN SPS.
Detection efficiency and spatial precision have been studied as a function of
the threshold and the track incidence angle. The experimental method, data
analysis and main results are presented.Comment: 10 pages, 9 figures, contribution to PIX2005 Workshop, Bonn
(Germany), 5-8 September 200
Molecular Landscape and Association with Crohn Disease of Poorly Cohesive Carcinomas of the Nonampullary Small Bowel
Objectives: Poorly cohesive carcinomas (PCCs) are neoplasms defined by a predominantly dyshesive growth pattern with single cell or cord-like stromal infiltration. The -distinctive clinicopathologic and prognostic features of small bowel PCCs (SB-PCCs) in comparison with conventional-type small intestinal adenocarcinomas have only recently been characterized. However, as SB-PCCs' genetic profile is still unknown, we aimed to analyze the molecular landscape of SB-PCCs. Methods: A next-generation sequencing analysis through Trusight Oncology 500 on a series of 15 nonampullary SB-PCCs was performed. Results: The most frequently found gene alterations were TP53 (53%) and RHOA (13%) mutations and KRAS amplification (13%), whereas KRAS, BRAF, and PIK3CA mutations were not identified. Most SB-PCCs (80%) were associated with Crohn disease, including both RHOA-mutated SB-PCCs, which featured a non-SRC-type histology, and showed a peculiar appendiceal-type, low-grade goblet cell adenocarcinoma (GCA)-like component. Rarely, SB-PCCs showed high microsatellite instability, mutations in IDH1 and ERBB2 genes, or FGFR2 amplification (one case each), which are established or promising therapeutic targets in such aggressive cancers. Conclusions: SB-PCCs may harbor RHOA mutations, which are reminiscent of the diffuse subtype of gastric cancers or appendiceal GCAs, while KRAS and PIK3CA mutations, commonly involved in colorectal and small bowel adenocarcinomas, are not typical of such cancers
Beam Test Performance and Simulation of Prototypes for the ALICE Silicon Pixel Detector
The silicon pixel detector (SPD) of the ALICE experiment in preparation at
the Large Hadron Collider (LHC) at CERN is designed to provide the precise
vertex reconstruction needed for measuring heavy flavor production in heavy ion
collisions at very high energies and high multiplicity. The SPD forms the
innermost part of the Inner Tracking System (ITS) which also includes silicon
drift and silicon strip detectors. Single assembly prototypes of the ALICE SPD
have been tested at the CERN SPS using high energy proton/pion beams in 2002
and 2003. We report on the experimental determination of the spatial precision.
We also report on the first combined beam test with prototypes of the other ITS
silicon detector technologies at the CERN SPS in November 2004. The issue of
SPD simulation is briefly discussed.Comment: 4 pages, 5 figures, prepared for proceedings of 7th International
Position Sensitive Detectors Conference, Liverpool, Sept. 200
Proton spectra from Non-Mesonic Weak Decay of p-shell Lambda-Hypernuclei and evidence for the two-nucleon induced process
New spectra from the FINUDA experiment of the Non Mesonic Weak Decay (NMWD)
proton kinetic energy for 9(Lambda)Be, 11(Lambda)B, 12(Lambda)C, 13(Lambda)C,
15 (Lambda)N and 16(Lambda)O are presented and discussed along with the
published data on 5(Lambda)He and 7(Lambda)Li. Exploiting the large mass number
range and the low energy threshold (15 MeV) for the proton detection of FINUDA,
an evaluation of both Final State Interactions (FSI) and the two nucleon
induced NMWD contributions to the decay process has been done. Based on this
evaluation, a linear dependence of FSI on the hypernuclear mass number A is
found and for the two nucleon stimulated decay rate the experimental value of
Gamma2/Gammap=0.43+-0.25 is determined for the first time. A value for the two
nucleon stimulated decay rate to the total decay rate
Gamma2/GammaNMWD=0.24+-0.10 is also extracted.Comment: 11 pages and 2 figure
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use greater than or equal to 5%.
Methods: This is a multicentre caseâcontrol study carried out in nine Italian hospitals from October 2010 to January 2014. Cases were adults, with a diagnosis of acute liver injury. Controls presented acute clinical disorders not related to chronic conditions, not involving the liver. Adjusted odds ratio (ORs) with 95% confidence interval (CI) were calculated initially with a bivariate and then multivariate analysis.
Results: We included 179 cases matched to 1770 controls. Adjusted OR for acute serious liver injury associated with all NSAIDs was 1.69, 95% CI 1.21â2.37. Thirty cases were exposed to nimesulide (adjusted OR 2.10, 95% CI 1.28â3.47); the risk increased according to the length of exposure (OR > 30 days: 12.55, 95% CI 1.73â90.88) and to higher doses (OR 10.69, 95% CI 4.02â28.44). Risk of hepatotoxicity was increased also for ibuprofen, used both at recommended dosages (OR 1.92, 95% CI 1.13â3.26) and at higher doses (OR 3.73, 95% CI 1.11â12.46) and for ketoprofen â„ 150 mg (OR 4.65, 95% CI 1.33â10.00).
Conclusion: Among all NSAIDs, nimesulide is associated with the higher risk, ibuprofen and high doses of ketoprofen are also associated with a modestly increased risk of hepatotoxicity
A study of the proton spectra following the capture of in Li and C with FINUDA
Momenta spectra of protons emitted following the capture of in Li
and C have been measured with 1% resolution. The C spectrum is
smooth whereas for Li a well defined peak appears at about 500 MeV/. The
first observation of a structure in this region was identified as a strange
tribaryon or, possibly, a -nuclear state. The peak is correlated with a
coming from decay in flight, selected by setting momenta
larger than 275 MeV/. The could be produced, together with a 500
MeV/ proton, by the capture of a in a deuteron-cluster substructure of
the Li nucleus. The capture rate for such a reaction is (1.62\pm
0.23_{stat} ^{+0.71}_{-0.44}(sys))%/K^-_{stop}, in agreement with the existing
observations on He targets and with the hypothesis that the Li nucleus
can be interpreted as a cluster.Comment: 21 pages, 10 figures. Accepted for publication in NP
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