50 research outputs found
A Bayesian analysis of neutron spin echo data on polymer coated gold nanoparticles in aqueous solutions
We present a neutron spin echo study (NSE) of the nanosecond dynamics of
polyethylene glycol (PEG) functionalised nanosized gold particles dissolved in
DO at two temperatures and two different PEG molecular weights. The
analysis of the NSE data was performed by applying a Bayesian approach to the
description of time correlation function decays in terms of exponential terms,
recently proved to be theoretically rigorous. This approach, which addresses in
a direct way the fundamental issue of model choice in any dynamical analysis,
provides here a guide to the most statistically supported way to follow the
decay of the Intermediate Scattering Functions I(Q, t) by basing on statistical
grounds the choice of the number of terms required for the description of the
nanosecond dynamics of the studied systems. Then, the presented analysis avoids
from the start resorting to a pre-selected framework and can be considered as
model free. By comparing the results of PEG coated nanoparticles with those
obtained in PEG2000 solutions, we were able to disentangle the translational
diffusion of the nanoparticles from the internal dynamics of the polymer
grafted to them, and to show that the polymer corona relaxation follows a pure
exponential decay in agreement with the behavior predicted by coarse grained
molecular dynamics simulations and theoretical models. This methodology has one
further advantage: in the presence of a complex dynamical scenario I(Q,t) is
often described in terms of the Kohlrausch-Williams-Watts function that can
implicitly represent a distribution of relaxation times. By choosing to
describe the I(Q,t) as a sum of exponential functions and with the support of
the Bayesian approach, we can explicitly determine when a finer-structure
analysis of the dynamical complexity of the system exists according to the
available data without the risk of overparametrisation
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Monolayer/Bilayer Transition in Langmuir Films of Derivatized Gold Nanoparticles at the Gas/Water Interface: An X-Ray Scattering Study
The microscopic structure of Langmuir films of derivatized gold nanoparticles has been studied as a function of area/particle on the water surface. The molecules (AuSHDA) consist of gold particles of mean core diameter D ∼ 22 Å that have been stabilized by attachment of carboxylic acid terminated alkylthiols, HS–(CH2)15–COOH. Compression of the film results in a broad plateau of finite pressure in the surface pressure versus area/particle isotherm that is consistent with a first-order monolayer/bilayer transition. X-ray specular reflectivity (XR) and grazing incidence diffraction show that when first spread at large area/particle, AuSHDA particles aggregate two dimensionally to form hexagonally packed monolayer domains at a nearest-neighbor distance of a = 34 Å. The lateral positional correlations associated with the two-dimensional (2D) hexagonal order are of short range and extend over only a few interparticle distances; this appears to be a result of the polydispersity in particle size. Subsequent compression of the film increases the surface coverage by the monolayer but has little effect on the interparticle distance in the close-packed domains. The XR and off-specular diffuse scattering (XOSDS) results near the onset of the monolayer/bilayer coexistence plateau are consistent with complete surface coverage by a laterally homogeneous monolayer of AuSHDA particles. On the high-density side of the plateau, the electron-density profile extracted from XR clearly shows the formation of a bilayer in which the newly formed second layer on top is slightly less dense than the first layer. In contrast to the case of the homogeneous monolayer, the XOSDS intensities observed from the bilayer are higher than the prediction based on the capillary wave model and the assumption of homogeneity, indicating the presence of lateral density inhomogeneities in the bilayer. According to the results of Bragg rod measurements, the 2D hexagonal order in the two layers of the bilayer are only partially correlated.Engineering and Applied Science
Nanopatterning Gold by Templated Solid State Dewetting on the Silica Warp and Weft of Diatoms
The diatom, Nitzschia palea, exhibits complex silica shell (frustule) topography that resembles the warp and weft pattern of woven glass. The surface is perforated with a rhombic lattice of roughly oblong pores between periodically undulating transverse weft costae. Exfoliated frustules can be used to template gold nanoparticles by thermally induced dewetting of thin gold films. Acting as templates for the process, the frustules give rise to two coexisting hierarchies of particle sizes and patterned distributions of nanoparticles. By examining temperature dependent dewetting of 5, 10, and 15 nm Au films for various annealing times, we establish conditions for particle formation and patterning. The 5 nm film gives distributions of small particles randomly distributed over the surface and multiple particles at the rhombic lattice points in the pores. Thicker films yield larger faceted particles on the surface and particles that exhibit shapes that are roughly conformal with the shape of the pore container. The pores and costae are sources of curvature instabilities in the film that lead to mass transport of gold and selective accumulation in the weft valleys and pores. We suggest that, with respect to dewetting, the frustule comprises 2-dimensional sublattices of trapping sites. The pattern of dewetting is radically altered by interposing a self-assembled molecular adhesive of mercaptopropyltrimethoxysilane between the Au film overlayer and the frustule. By adjusting the interfacial energy in this manner, a fractal-like overlay of Au islands coexists with a periodic distribution of nanoparticles in the pores
A comprehensive study of GRB 070125, a most energetic gamma ray burst
We present a comprehensive multiwavelength analysis of the bright, long
duration gamma-ray burst GRB 070125, comprised of observations in -ray,
X-ray, optical, millimeter and centimeter wavebands. Simultaneous fits to the
optical and X-ray light curves favor a break on day 3.78, which we interpret as
the jet break from a collimated outflow. Independent fits to optical and X-ray
bands give similar results in the optical bands but shift the jet break to
around day 10 in the X-ray light curve. We show that for the physical
parameters derived for GRB 070125, inverse Compton scattering effects are
important throughout the afterglow evolution. While inverse Compton scattering
does not affect radio and optical bands, it may be a promising candidate to
delay the jet break in the X-ray band. Radio light curves show rapid flux
variations, which are interpreted as due to interstellar scintillation, and are
used to derive an upper limit of cm on the radius of the
fireball in the lateral expansion phase of the jet. Radio light curves and
spectra suggest a high synchrotron self absorption frequency indicative of the
afterglow shock wave moving in a dense medium. Our broadband modeling favors a
constant density profile for the circumburst medium over a wind-like profile
(). However, keeping in mind the uncertainty of the parameters, it is
difficult to unambiguously distinguish between the two density profiles. Our
broadband fits suggest that \event is a burst with high radiative efficiency
().Comment: 50 pages, 33 figures, sty file included, Appeared in 20 Aug 2008
edition of Astrophysical Journa
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified