534 research outputs found

    Travels to an Ancestral Past: On Diasporic Tourism, Embodied Memory, and Identity

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    This paper explores 'roots tourism' as a diasporic identity practice. Drawing on accounts of voyages made by members of several different diasporic populations, I demonstrate that attention to individual tourist experience reveals a subjective focus on the sensing body as a key component of touristic 'return' to ancestral homelands. Through sensory engagement with their physical surroundings, travelers undertake commemorative practices that somatically and imaginatively unite them with their forebears, thus bridging the diasporic rupture of past and present, ancestors and selves, homeland and exile

    Locating Imaginaries in the Anthropology of Tourism

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    Cultura e Sociedade e o trñnsito entre a “alta” e “baixa” cultura

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    Percorrendo os artigos que compĂ”e a organização do livro Cultura e Sociedade: Brasil e Argentina, essa resenha busca refletir sobre a maneira atravĂ©s da qual os produtos culturais, sobretudo, da chamada indĂșstria cultural vĂȘm sido abordados pela sociologia da cultura no Brasil, do mesmo modo em que procura identificar tambĂ©m novas possibilidades e abordagens para essa problemĂĄtica

    L’anthropologie pour Ă©tudier le tourisme

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    CentrĂ© sur l’anthropologie anglophone, cet article retrace l’émergence de l’étude du tourisme comme champ social et comme phĂ©nomĂšne culturel particulier. Le texte prĂ©sente ensuite les auteurs et les grandes notions qui ont structurĂ© la recherche depuis les annĂ©es 1970 : le dĂ©veloppement du tourisme et ses impacts ; le genre, la sexualitĂ© et le corps ; l’art pour touristes, l’authenticitĂ©, l’ethnicitĂ©, l’identitĂ© et le patrimoine. Il expose les enquĂȘtes actuelles en rĂ©vĂ©lant l’importance de l’angle d’observation : les lieux et leurs images, les gens et leurs expĂ©riences, le mouvement, les choses, la mondialisation. Enfin, prenant acte de la mondialisation des pratiques touristiques comme de la maturitĂ© des recherches anthropologiques, les auteurs proposent d’aller plus loin en considĂ©rant dĂ©sormais le tourisme d’un point de vue holiste, c’est-Ă -dire comme un Ă©lĂ©ment inextricablement liĂ© Ă  la vie sociale, culturelle et Ă©conomique. Ils tracent des pistes de recherche sur les liens entre tourisme et mĂ©decine, tourisme et mĂ©dias, tourisme et pouvoir, tourisme et engagement, ou encore, tourisme et parentĂ©.Focusing on anglophone anthropology, this article traces the emergence of tourism studies both as an academic field and as a cultural phenomenon. The text presents authors and key concepts that have structured the critical research of tourism since the 1970s: tourism development and its ‘impacts’; gender, sexuality and the body; tourist arts; ‘authenticity’; ‘ethnicity, identity and heritage’. The authors, then, outline different current study topics and their specific anthropological approaches: place and imagery; people and their experiences; movement, things and the global. Noting the global dimension of tourism practices and the maturity of anthropological research on tourism, the authors propose to go further by considering tourism from a holistic point of view, as an inextricable aspect of social, cultural and economic life being formed at the global scale. They trace new perspectives on links between tourism and medicine, tourism and media, tourism and power, tourism and activism, and, tourism and kinship

    Cultura e Sociedade e o trĂąnsito entre a "alta" e "baixa" cultura

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    Percorrendo os artigos que compĂ”e a organização do livro Cultura e Sociedade: Brasil e Argentina, essa resenha busca refletir sobre a maneira atravĂ©s da qual os produtos culturais, sobretudo, da chamada indĂșstria cultural vĂȘm sido abordados pela sociologia da cultura no Brasil, do mesmo modo em que procura identificar tambĂ©m novas possibilidades e abordagens para essa problemĂĄtica

    O RECONHECIMENTO DO BEM ESTAR DO TRABALHADOR E A RESPONSABILIDADE SOCIAL CORPORATIVA: ANÁLISE DE ESTUDOS DE CASO BRASILEIRO

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    Os trabalhadores sĂŁo partes interessadas nas operaçÔes das organizaçÔes, pautando açÔes de Responsabilidade Social com o bem estar. Nessa perspectiva, compreende-se uma relação integradora entre sustentabilidade e ergonomia, abrangendo a concepção de sistemas harmĂŽnicos entre força de trabalho saudĂĄvel e produtiva. Quanto ao objetivo, o estudo buscou identificar se as organizaçÔes reconhecidas por proporcionar bem estar aos trabalhadores, consideradas melhores para trabalhar, tambĂ©m sĂŁo caracterizadas por prĂĄticas em Responsabilidade Social Corporativa - RSC. No que se refere aos procedimentos metodolĂłgicos, trata-se de estudo de caso mĂșltiplo, com informaçÔes coletadas de fontes secundĂĄrias, websites e relatĂłrios de sustentabilidade. Os dados foram descritos e exposto em quadros que permitiram uma visualização sintetizada dos reconhecimentos auferidos pelas organizaçÔes. Foram trĂȘs empresas selecionadas, a Elektro, Sama e SAP Labs Latin America, referenciadas, cada uma no seu setor de atuação, na revista VocĂȘ SA, que em metodologia prĂłpria, define um Ă­ndice de felicidade no trabalho - IFT. Os resultados evidenciaram que organizaçÔes reconhecidas por proporcionar bem estar aos seus trabalhadores tambĂ©m sĂŁo caracterizadas como atuantes em iniciativas de RSC, indicando uma possĂ­vel relação entre bem estar e RSC, dado que corporaçÔes que se preocupam com questĂ”es de sustentabilidade coorporativa influenciam em termos de atratividade e percepção dos seus funcionĂĄrios. Cabe destacar, que em ambas as organizaçÔes estudadas, atuantes de forma global, foram identificados aspectos de transparĂȘncia e credibilidade nos relatĂłrios de sustentabilidade divulgados, tendo em vista a padronização, conforme as diretrizes do Global Reporting Initiative – GRI

    Fatores relacionados ao consumo da carne de peixe pela população de Campo Grande, MS, Brasil / Factors related to the consumption of fish meat by the population of Campo Grande, MS, Brazil

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    A carne de peixe Ă© um alimento com excelente valor nutricional, sendo uma proteĂ­na de origem animal muito consumida pela população mundial, pois exerce um importante papel na alimentação e na saĂșde humana. Objetivou-se com o presente artigo identificar as preferĂȘncias dos consumidores de carne de peixe em relação ao grau de importĂąncia dos atributos relacionados Ă  venda e a produção do peixe no ato da compra. A anĂĄlise foi realizada por meio de questionĂĄrios aplicados a 150 consumidores em quatro supermercados da cidade de Campo Grande – MS. Os indivĂ­duos que responderam ao questionĂĄrio classificaram a espĂ©cie do peixe (5,59±0,16) como atributo mais importante do produto e em seguida o sistema de produção (5,03±0,19). Para o ponto de venda, os consumidores disseram que o preço (5,59±0,15) e a disponibilidade de cortes especiais (5,57±0,14) sĂŁo os mais importantes. Observou-se que homens se atentam mais a embalagem (4,92±0,27) em que o peixe Ă© comercializado e ao fator presença de espinha (3,35±0,26) do que as mulheres (4,12±0,25; 2,65±0,19). AlĂ©m disso, de acordo com o grau de escolaridade dos entrevistados a importĂąncia da caracterĂ­stica de odor do peixe diferiu significativamente, atĂ© fundamental completo (5,00±0,62), atĂ© ensino mĂ©dio completo (5,96±0,26) e atĂ© ensino superior completo (6,25±0,15). Conclui-se que os consumidores entrevistados atribuĂ­ram maior importĂąncia as questĂ”es sensoriais, relacionadas ao produto, sua produção e comercialização

    Consumidores de carne bovina: comportamento e preferĂȘncias / Beef consumers: behaviour and preferences

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    Compreender as preferĂȘncias e hĂĄbitos dos consumidores de carne bovina, bem como os fatores que os levam a comprar, possibilita ao mercado um atendimento satisfatĂłrio aos clientes. Dessa forma foram entrevistadas 150 pessoas em quatro supermercados da cidade de Campo Grande – MS com o objetivo de identificar as preferĂȘncias dos consumidores em relação aos atributos no ato da compra da carne bovina nos supermercados. Os entrevistados escolheram as caracterĂ­sticas sensoriais de odor (6,73±0,06), cor (6,64±0,07), maciez (6,40±0,08) como as mais importantes. Em relação ao produto eles destacaram a embalagem (4,83±0,19) e origem (4,21±0,21) como atributos mais verifi-cados no ato da compra, sendo que no ponto de venda eles consideram a disponibilidade de tipos de cortes, de cortes especiais e o preço como atributos extremamente importantes (p0,001). As dife-renças de preferĂȘncias encontradas em relação ao sexo, renda, escolaridade e modo de viver possibi-litam ao mercado direcionar produtos especĂ­ficos a cada tipo de consumidor

    EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen: Focused Compound Screen in Chordoma

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    Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic options. We undertook a focused compound screen (FCS) against 1097 compounds on three well-characterized chordoma cell lines; 154 compounds were selected from the single concentration screen (1 ”m), based on their growth-inhibitory effect. Their half-maximal effective concentration (EC50 ) values were determined in chordoma cells and normal fibroblasts. Twenty-seven of these compounds displayed chordoma selective cell kill and 21/27 (78%) were found to be EGFR/ERBB family inhibitors. EGFR inhibitors in clinical development were then studied on an extended cell line panel of seven chordoma cell lines, four of which were sensitive to EGFR inhibition. Sapitinib (AstraZeneca) emerged as the lead compound, followed by gefitinib (AstraZeneca) and erlotinib (Roche/Genentech). The compounds were shown to induce apoptosis in the sensitive cell lines and suppressed phospho-EGFR and its downstream pathways in a dose-dependent manner. Analysis of substituent patterns suggested that EGFR-inhibitors with small aniline substituents in the 4-position of the quinazoline ring were more effective than inhibitors with large substituents in that position. Sapitinib showed significantly reduced tumour growth in two xenograft mouse models (U-CH1 xenograft and a patient-derived xenograft, SF8894). One of the resistant cell lines (U-CH2) was shown to express high levels of phospho-MET, a known bypass signalling pathway to EGFR. Neither amplifications (EGFR, ERBB2, MET) nor mutations in EGFR, ERBB2, ERBB4, PIK3CA, BRAF, NRAS, KRAS, PTEN, MET or other cancer gene hotspots were detected in the cell lines. Our findings are consistent with the reported (p-)EGFR expression in the majority of clinical samples, and provide evidence for exploring the efficacy of EGFR inhibitors in the treatment of patients with chordoma and studying possible resistance mechanisms to these compounds in vitro and in vivo. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland

    Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

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    Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. However, the prevalence of LATE-NC across the full range of ADNC remains uncertain. To address this knowledge gap, neuropathologic, genetic, and clinical data were compiled from 13 high-quality community- and population-based longitudinal studies. Participants were recruited from United States (8 cohorts, including one focusing on Japanese–American men), United Kingdom (2 cohorts), Brazil, Austria, and Finland. The total number of participants included was 6196, and the average age of death was 88.1 years. Not all data were available on each individual and there were differences between the cohorts in study designs and the amount of missing data. Among those with known cognitive status before death (n = 5665), 43.0% were cognitively normal, 14.9% had MCI, and 42.4% had dementia—broadly consistent with epidemiologic data in this age group. Approximately 99% of participants (n = 6125) had available CERAD neuritic amyloid plaque score data. In this subsample, 39.4% had autopsy-confirmed LATE-NC of any stage. Among brains with “frequent” neuritic amyloid plaques, 54.9% had comorbid LATE-NC, whereas in brains with no detected neuritic amyloid plaques, 27.0% had LATE-NC. Data on LATE-NC stages were available for 3803 participants, of which 25% had LATE-NC stage > 1 (associated with cognitive impairment). In the subset of individuals with Thal AÎČ phase = 0 (lacking detectable AÎČ plaques), the brains with LATE-NC had relatively more severe primary age-related tauopathy (PART). A total of 3267 participants had available clinical data relevant to frontotemporal dementia (FTD), and none were given the clinical diagnosis of definite FTD nor the pathological diagnosis of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). In the 10 cohorts with detailed neurocognitive assessments proximal to death, cognition tended to be worse with LATE-NC across the full spectrum of ADNC severity. This study provided a credible estimate of the current prevalence of LATE-NC in advanced age. LATE-NC was seen in almost 40% of participants and often, but not always, coexisted with Alzheimer’s disease neuropathology
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