Predictive Validity of the Individual Growth and Development Indicators: Examination of Students who Attend Head Start

The purpose of the current study was to explore the predictive nature of emergent literacy skills assessed utilizing the Individual Growth and Development Indicators (IGDIs; Early Childhood Research Institute on Measuring Growth and Development, 2000) prior to kindergarten entry on subsequent early literacy skills obtained through administration of Dynamic Indicators of Basic Early Literacy Skills (DIBELS,6th Edition; Good & Kaminski, 2002) during kindergarten. The study was conducted with a group of 94 students who attended Head Start, some of whom were considered Dual Language Learners, having a Primary Language Status (PLS) other than English. Potential predictive bias of the IGDIs on the DIBELS based on parent-reported primary language status (i.e., Primary Language English or Primary Language as Other) as well as performance on specific literacy variables based on language status were also assessed. Overall results indicated that IGDIs were less predictive of kindergarten DIBELS measures than previously demonstrated in extant literature. In addition, differences on literacy variables based on PLS were only found on one preschool measure and were not found on any kindergarten measure. Finally, no evidence for predictive bias was found based on PLS. This investigation reinforces the need for further attention and development in the area of literacy assessment for specific groups of young children

La realidad virtual como herramienta versátil de investigación, difusión y mediación en las humanidades

[EN] The VESPACE project aims to revive an evening of theatre at the Foire Saint-Germain in Paris in the 18th century, by recreating spaces, atmospheres and theatrical entertainment in virtual reality. The venues of this fair have disappeared without leaving any archaeological traces, so their digital reconstruction requires the use of many different sources, including the expertise of historians, historians of theatre and literature. In this article, we present how we have used video game creation tools to enable the use of virtual reality in three key stages of research in the human sciences and particularly in history or archaeology: preliminary research, scientific dissemination and mediation with the general public. In particular, we detail the methodology used to design a three-dimensional (3D) model that is suitable for both research and virtual reality visualization, meets the standards of scientific work regarding precision and accuracy, and the requirements of a real-time display. This model becomes an environment in which experts can be immersed within their fields of research and expertise, and thus extract knowledge reinforcing the model created –through comments, serendipity and new perspectives– while enabling a multidisciplinary workflow. We also present our tool for annotating and consulting sources, relationships and hypotheses in immersion, called PROUVÉ. This tool is designed to make the virtual reality experience go beyond a simple image and to convey scientific information and theories in the same way an article or a monograph does. Finally, this article offers preliminary feedback on the use of our solutions with three target audiences: the researchers from our team, the broader theatre expert community and the general public.[ES] El proyecto VESPACE tiene como objetivo revivir una velada de teatro en la Foire Saint-Germain de París en el siglo XVIII, recreando espacios, atmósferas y entretenimiento teatral en realidad virtual. Las sedes de esta feria han desaparecido sin dejar ningún rastro arqueológico, por lo que su reconstrucción digital requiere el uso de muy diversas fuentes, entre las que se encuentran expertos historiadores, historiadores del teatro y la literatura. En este artículo presentamos cómo hemos utilizado las herramientas de creación de videojuegos que posibilitan el uso de la realidad virtual en tres etapas clave de la investigación en las ciencias humanas y particularmente en historia o arqueología: investigación preliminar, divulgación científica y mediación con el público en general. En particular, detallamos la metodología utilizada para diseñar un modelo tridimensional (3D) que sea adecuado tanto para la investigación como para la visualización mediante realidad virtual, que cumpla con los estándares del trabajo científico en cuanto a precisión y exactitud, y los requisitos de una visualización en tiempo real. Este modelo se convierte en un entorno en el que los expertos pueden sumergirse dentro de sus campos de investigación y especialización, y así extraer conocimiento reforzando el modelo creado –a través de comentarios, serendipia y nuevas perspectivas– al tiempo que posibilita un flujo de trabajo multidisciplinar. También presentamos nuestra herramienta de anotación y consulta de fuentes, relaciones e hipótesis en inmersión, denominada PROUVÉ. Esta herramienta está diseñada para hacer que la experiencia de la realidad virtual vaya más allá de una simple imagen y que transmita información científica y teorías de la misma manera que lo hace un artículo o una monografía. Finalmente, este artículo ofrece comentarios preliminares sobre el uso de nuestras soluciones con tres públicos objetivo: los investigadores de nuestro equipo, la comunidad de expertos en teatro (más amplia) y el público en general.This research was funded in France by the Agence Nationale de la Recherche, with the CIRESFI project, Grant No. ANR 14-CE31-0017, and the ReSeed project, Grant No. ANR 16-CE38-0005, and a grant from RFI Pays de la Loire "Ouest Industries Créatives" and the École Centrale de Nantes for the AAP 2017 VESPACE project. In the United States, the project is supported by the National Endowment for Humanities, Grant No. NEH HAA-266501-19.François, P.; Leichman, J.; Laroche, F.; Rubellin, F. (2021). 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Exploring Effects of Screen-Fixed and World-Fixed Annotation on Navigation in Virtual Reality. IEEE Conference on Virtual Reality and 3D User Interfaces. IEEE Conference on Virtual Reality and 3D User Interfaces, 607-615. https://doi.org/10.1109/VR46266.2020.00083Falconer, L., Burden, D., Cleal, R., Hoyte, R., Phelps, P., Slawson, N., Snashall, N., & Welham, K. (2020). Virtual Avebury : exploring sense of place in a virtual archaeology simulation. Virtual Archaeology Review, 11(23), 50-62. https://doi.org/10.4995/var.2020.12924François, P. (2021). La Foire Saint-Germain vers 1770 : Images et mutations des lieux de spectacle. Actes de la journée d'études Permanences et mutations des espaces du spectacle vivant dans la ville (de 1750 à nos jours). Permanences et mutations des espaces du spectacle vivant dans la ville (de 1750 à nos jours), Bordeaux. In press.François, P., Laroche, F., Rubellin, F., & Leichman, J. (2019). 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New Library World, 115(3/4), 75-86. https://doi.org/10.1108/NLW-01-2014-0013Hvass, J., Larsen, O., Vendelbo, K., Nilsson, N., Nordahl, R., & Serafin, S. (2017). Visual Realism and Presence in a Virtual Reality Game. 3DTV Conference 2017: Research and Applications in Future 3D Media. 3DTV Conference 2017: Research and Applications in Future 3D Media, Copenhague. https://doi.org/10.1109/3DTV.2017.8280421ICOMOS (2017). Principles of Seville. International Principles of Virtual Archaeology. https://icomos.es/wp-content/uploads/2020/06/Seville-Principles-IN-ES-FR.pdfKilteni, K., Groten, R., & Slater, M. (2012). The Sense of Embodiment in Virtual Reality. PRESENCE: Teleoperators and Virtual Environments, 21(4), 373-387. https://doi.org/10.1162/PRES_a_00124Krasniewicz, L. (2000). Immersive imaging technologies for archaeological research. Virtual Reality in Archaeology, 843, 163 169.Laroche, F. (2017). KLM for Heritage [Mémoire d'Habilitation à Diriger des Recherches]. 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Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival.

PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 patients with colorectal cancer.ResultsMost patients (96%) had metastatic or recurrent disease at the time of blood draw. The median number of nonsynonymous alterations per patient was three (range, zero to 30). The most frequently aberrant genes were TP53 (52.1% of patients), KRAS (34%), and APC (28.7%). Concordance between tissue and blood next-generation sequencing ranged from 63.2% (APC) to 85.5% (BRAF). Altogether, 74 patients (79%) had one or more nonsynonymous alterations, 69 (73%) had one or more potentially actionable alterations, and 61 (65%) had an alteration actionable by a drug approved by the US Food and Drug Administration (on or off label). Lung metastases correlated with improved survival from diagnosis in univariable analysis. ctDNA of 5% or more from blood tests as well as EGFR and ERBB2 (HER2) nonsynonymous alterations correlated with worse survival (but only ERBB2 remained significant in multivariable analysis). No two patients had identical molecular portfolios. Overall, 65% versus 31% of patients treated with matched (n = 17) versus unmatched therapy (n = 18) after ctDNA testing achieved stable disease for 6 months or more, partial response, or complete response (P = .045); progression-free survival, 6.1 versus 2.3 months (P = .08); and survival not reached versus 9.4 months (P = .146; all by multivariable analysis).ConclusionPatients with colorectal cancer have heterogeneous ctDNA profiles, and most harbor potentially actionable ctDNA alterations. Matched therapy yielded higher rates of stable disease for 6 months or more, partial response, or complete response. ctDNA assessment may have clinical utility and merits further investigation

Cetuximab as Second-Line Therapy in Patients with Metastatic Esophageal Adenocarcinoma: A Phase II Southwest Oncology Group Study (S0415)

IntroductionEsophageal adenocarcinomas commonly express the epidermal growth factor receptor. This trial assessed the 6-month overall survival probability in metastatic esophageal cancer patients treated with cetuximab as second-line therapy.MethodsThis was a multicenter, open-label phase II study of single-agent cetuximab for metastatic esophageal adenocarcinoma patients who failed one prior chemotherapy regimen. Adequate organ function and Zubrod performance status of 0 to 2 were required. Patients received cetuximab 400 mg/m2 intravenously (IV) on week 1 and 250 mg/m2 IV weekly thereafter. The primary objective was to determine 6-month overall survival. Secondary end points included progression-free survival, response rate, and toxicity. Tumor tissue was collected for correlative studies.ResultsSixty-three patients were registered, with eight ineligible or never treated. Fifty-five eligible patients (49 men, 6 women; median age = 61.2 years [range, 30.7–88.5]) were enrolled. Twenty patients survived more than 6 months for a 6-month overall survival rate of 36% (95% confidence interval [CI]: 24–50%). The median overall survival was 4.0 months (95% CI: 3.2–5.9). Median progression-free survival was 1.8 months (95% CI: 1.7–1.9). One partial response and two unconfirmed partial responses were observed. Two patients experienced grade 4 fatigue. There was one treatment-related death due to pneumonitis. Germline polymorphisms of epidermal growth factor receptor, epidermal growth factor, interleukin (IL)-8, cyclooxygenase (COX)-2, vascular epidermal growth factor receptor (VEGF), CCND1, neuropilin 1 (NRP1), and K-ras mutational status were not associated with response or survival.ConclusionsThe 6-month overall survival rate of 36% observed on this study failed to meet the primary survival objective. Thus, cetuximab alone cannot be recommended in the second-line treatment of metastatic esophageal cancer

De l'usage à l'espace : prospective pour une rétro-architecture

National audienceLa restitution historique de bâtiments disparus nécessite de convoquer de nombreuses sources de formes différentes, mais aucune trace physique de l'élément à restituer. Afin de pallier cette difficulté, cet article entend proposer le recours à l'immersion virtuelle d'experts dans l'espace restitué. Cette immersion permet de susciter des commentaires conscients ou inconscients, de l'ordre du sensible, des postures corporelles, qui sont autant de sources supplémentaires permettant de guider ou de renseigner un processus de restitution historique. Nous prenons pour exemple les théâtres de la Foire Saint-Germain à Paris au XVIII e siècle-pour lesquelles une importante documentation historique existe, mais aucun vestige archéologique-dans le but de proposer une première ébauche de méthodologie intégrant la sensibilité d'experts pour une rétro-architecture de ces espaces

Progressive regression of left ventricular hypertrophy two years after bariatric surgery.

BACKGROUND: Obesity is a systemic disorder associated with an increase in left ventricular mass and premature death and disability from cardiovascular disease. Although bariatric surgery reverses many of the hormonal and hemodynamic derangements, the long-term collective effects on body composition and left ventricular mass have not been considered before. We hypothesized that the decrease in fat mass and lean mass after weight loss surgery is associated with a decrease in left ventricular mass. METHODS: Fifteen severely obese women (mean body mass index [BMI]: 46.7+/-1.7 kg/m(2)) with medically controlled hypertension underwent bariatric surgery. Left ventricular mass and plasma markers of systemic metabolism, together with body mass index (BMI), waist and hip circumferences, body composition (fat mass and lean mass), and resting energy expenditure were measured at 0, 3, 9, 12, and 24 months. RESULTS: Left ventricular mass continued to decrease linearly over the entire period of observation, while rates of weight loss, loss of lean mass, loss of fat mass, and resting energy expenditure all plateaued at 9 [corrected] months (P \u3c.001 for all). Parameters of systemic metabolism normalized by 9 months, and showed no further change at 24 months after surgery. CONCLUSIONS: Even though parameters of obesity, including BMI and body composition, plateau, the benefits of bariatric surgery on systemic metabolism and left ventricular mass are sustained. We propose that the progressive decrease of left ventricular mass after weight loss surgery is regulated by neurohumoral factors, and may contribute to improved long-term survival

Achalasia Combined with Esophageal Cancer Treated by Concurrent Chemoradiation Therapy

Achalasia is a rare neurological deficit of the esophagus that produces an impaired relaxation of the lower esophageal sphincter and decreased motility of the esophageal body. Achalasia is generally accepted to be a pre-malignant disorder, since, particularly in the mega-esophagus, chronic irritation by foods and bacterial overgrowth may contribute to the development of dysplasia and carcinoma. We present a case of a 51-year-old man with achalasia combined with esophageal cancer who has had dysphagia symptoms for more than 20 years. Since there was a clinically high possibility of supraclavicular lymph node metastasis, concurrent chemoradiation therapy was scheduled. After the third cycle of chemoradiation therapy, transthoracic esophageolymphadenectomy was performed. Histopathological examination of the main esophagus specimen revealed no residual carcinoma. And the entire regional lymph node areas were free of carcinoma except for one azygos metastatic lymph node. In summary, achalasia is a predisposing factor for esophageal squamous cell carcinoma. Although surveillance endoscopy in achalasia patients is still controversial, periodic screening for cancer development in long-standing achalasia patients might be advisable

Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost

Chemoradiotherapy (CRT) is now widely accepted as the primary treatment modality for squamous cell cancer of the anus. While randomised trials have clearly shown CRT to be more effective than radiotherapy alone, there remains uncertainty over the optimal integration of chemotherapy and radiation. We describe a series of 50 patients treated by a site specialist gastrointestinal nonsurgical oncologist with CRT at a single UK centre. Chemotherapy comprised mitomycin C (MMC) (day 1) and 5-fluorouracil (5-FU) (days 1–4, and 29–32), concurrent with 50 Gy in 25 fractions radiation, using a two-phase shrinking field technique. A radiation boost was not planned. At a median follow-up of 48 months, 11 (22%) of the patients have failed locally, of which three have been surgically salvaged. Nine (18%) have died of anal cancer. These results are comparable with those from large randomised studies, and suggest that a two-phase shrinking field radiotherapy technique with no boost, concurrent with MMC/5-FU chemotherapy, is an effective regimen for this disease. The CRT regimen described here provides the basis for the ‘control arm’ of the current UK-randomised CRT trial in anal cancer (ACT2)