Impact of {\eta}earth on the capabilities of affordable space missions to detect biosignatures on extrasolar planets

We present an analytic model to estimate the capabilities of space missions dedicated to the search for biosignatures in the atmosphere of rocky planets located in the habitable zone of nearby stars. Relations between performance and mission parameters such as mirror diameter, distance to targets, and radius of planets, are obtained. Two types of instruments are considered: coronagraphs observing in the visible, and nulling interferometers in the thermal infrared. Missions considered are: single-pupil coronagraphs with a 2.4 m primary mirror, and formation flying interferometers with 4 x 0.75 m collecting mirrors. The numbers of accessible planets are calculated as a function of {\eta}earth. When Kepler gives its final estimation for {\eta}earth, the model will permit a precise assessment of the potential of each instrument. Based on current estimations, {\eta}earth = 10% around FGK stars and 50% around M stars, the coronagraph could study in spectroscopy only ~1.5 relevant planets, and the interferometer ~14.0. These numbers are obtained under the major hypothesis that the exozodiacal light around the target stars is low enough for each instrument. In both cases, a prior detection of planets is assumed and a target list established. For the long-term future, building both types of spectroscopic instruments, and using them on the same targets, will be the optimal solution because they provide complementary information. But as a first affordable space mission, the interferometer looks the more promising in term of biosignature harvest.Comment: Accepted by Ap

Measuring the masses of the habitable planets around the 50 closest solar-type stars with Theia

A major goal of exoplanetary science is the search for possible biosignatures on planets where life similar to ours would have emerged and modified the atmosphere. These planets can be detected by remote sensing using spectroscopic observation of O2, O3, H2O, CO2, and CH4 gases, but in the present context of funding, only missions in the range B$1-2 are seen as feasible for the next decades. This cost cap imposes serious constraints on the number of accessible targets limiting the exploration to the 20 nearest systems with space coronagraphy in the visible wavelength range and 40 systems with space interferometers working in thermal IR. It is thus imperative that promising target be identified ahead of time, to minimize several classes of risks intrinsic to the 'blind search' approach. Furthermore, the masses and the three-dimensional orbits of such habitable planets are key elements for deriving exobiological statements in the future, even the most basic ones. The mission called Theia has been submitted to the ESA call for M4 mission in 2015. Theia is a space observatory able to carry out high precision differential astrometry at the sub-microarcsecond level that allows mass determination of Earth-mass habitable planets around the 50 closest Solar-type stars using 15 - 20 % of the time of a three years mission. Theia is a single telescope designed to perform high accuracy astrometry using interferometric calibration and operating in L2. We will present the mission and its capability to measure the mass and orbit characteristics of the 50 closest planetary systems down to the Earth mass in the habitable zone of solar-type stars

National Accounts ESA. Aggregates 1970-1975. 1976

<p>Model 3 multiple logistic regression analysis for burnout diagnosis.</p

Sea level along the world’s coastlines can be measured by a network of virtual altimetry stations

For nearly 30 years, space-based radar altimetry has been routinely measuring changes in sea level at global and regional scales. But this technique designed for the open ocean does not provide reliable sea level data within 20 km to the coast, mostly due to land contamination within the radar echo in the vicinity of the coast. This problem can now be overcome through dedicated reprocessing, allowing the retrieval of valid sea level data in the 0-20 km band from the coast, and then the access to novel information on sea level change in the world coastal zones. Here we present sea level anomalies and associated coastal sea level trends at 756 altimetry-based virtual coastal stations located along the coasts of North and South America, Northeast Atlantic, Mediterranean Sea, Africa, North Indian Ocean, Asia and Australia. This new dataset, derived from the reprocessing of high-resolution (300 m) along-track altimetry data from the Jason-1, 2 and 3 missions from January 2002 to December 2019, allows the analysis of the decadal evolution of coastal sea level and fills the coastal gap where sparse sea level information is currently available

a planned ancillary analysis of the coVAPid cohort

Funding: This study was supported in part by a grant from the French government through the «Programme Investissement d’Avenir» (I-SITE ULNE) managed by the Agence Nationale de la Recherche (coVAPid project). The funders of the study had no role in the study design, data collection, analysis, or interpreta tion, writing of the report, or decision to submit for publication.BACKGROUND: Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients. METHODS: Planned ancillary analysis of a multicenter retrospective European cohort. VAP was diagnosed using clinical, radiological and quantitative microbiological criteria. Univariable and multivariable marginal Cox's regression models, with cause-specific hazard for duration of mechanical ventilation and ICU stay, were used to compare outcomes between study groups. Extubation, and ICU discharge alive were considered as events of interest, and mortality as competing event. FINDINGS: Of 1576 included patients, 568 were SARS-CoV-2 pneumonia, 482 influenza pneumonia, and 526 no evidence of viral infection at ICU admission. VAP was associated with significantly higher risk for 28-day mortality in SARS-CoV-2 (adjusted HR 1.70 (95% CI 1.16-2.47), p = 0.006), and influenza groups (1.75 (1.03-3.02), p = 0.045), but not in the no viral infection group (1.07 (0.64-1.78), p = 0.79). VAP was associated with significantly longer duration of mechanical ventilation in the SARS-CoV-2 group, but not in the influenza or no viral infection groups. VAP was associated with significantly longer duration of ICU stay in the 3 study groups. No significant difference was found in heterogeneity of outcomes related to VAP between the 3 groups, suggesting that the impact of VAP on mortality was not different between study groups. INTERPRETATION: VAP was associated with significantly increased 28-day mortality rate in SARS-CoV-2 patients. However, SARS-CoV-2 pneumonia, as compared to influenza pneumonia or no viral infection, did not significantly modify the relationship between VAP and 28-day mortality. CLINICAL TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov, number NCT04359693.publishersversionpublishe

Role of the Lateral Paragigantocellular Nucleus in the Network of Paradoxical (REM) Sleep: An Electrophysiological and Anatomical Study in the Rat

The lateral paragigantocellular nucleus (LPGi) is located in the ventrolateral medulla and is known as a sympathoexcitatory area involved in the control of blood pressure. In recent experiments, we showed that the LPGi contains a large number of neurons activated during PS hypersomnia following a selective deprivation. Among these neurons, more than two-thirds are GABAergic and more than one fourth send efferent fibers to the wake-active locus coeruleus nucleus. To get more insight into the role of the LPGi in PS regulation, we combined an electrophysiological and anatomical approach in the rat, using extracellular recordings in the head-restrained model and injections of tracers followed by the immunohistochemical detection of Fos in control, PS-deprived and PS-recovery animals. With the head-restrained preparation, we showed that the LPGi contains neurons specifically active during PS (PS-On neurons), neurons inactive during PS (PS-Off neurons) and neurons indifferent to the sleep-waking cycle. After injection of CTb in the facial nucleus, the neurons of which are hyperpolarized during PS, the largest population of Fos/CTb neurons visualized in the medulla in the PS-recovery condition was observed in the LPGi. After injection of CTb in the LPGi itself and PS-recovery, the nucleus containing the highest number of Fos/CTb neurons, moreover bilaterally, was the sublaterodorsal nucleus (SLD). The SLD is known as the pontine executive PS area and triggers PS through glutamatergic neurons. We propose that, during PS, the LPGi is strongly excited by the SLD and hyperpolarizes the motoneurons of the facial nucleus in addition to local and locus coeruleus PS-Off neurons, and by this means contributes to PS genesis