Gravity, Topography, and Melt Generation Rates From Simple 3-D Models of Mantle Convection

Convection in fluid layers at high Rayleigh number (Ra $\sim 10^6$) have a spoke pattern planform. Instabilities in the bottom thermal boundary layer develop into hot rising sheets of fluid, with a component of radial flow towards a central upwelling plume. The sheets form the "spokes" of the pattern, and the plumes the "hubs". Such a pattern of flow is expected to occur beneath plate interiors on Earth, but it remains a challenge to use observations to place constraints on the convective planform of the mantle. Here we present predictions of key surface observables (gravity, topography, and rates of melt generation) from simple 3D numerical models of convection in a fluid layer. These models demonstrate that gravity and topography have only limited sensitivity to the spokes, and mostly reflect the hubs (the rising and sinking plumes). By contrast, patterns of melt generation are more sensitive to short wavelength features in the flow. There is the potential to have melt generation along the spokes, but at a rate which is relatively small compared with that at the hubs. Such melting of spokes can only occur when the lithosphere is sufficiently thin ($\lesssim 80$ km) and mantle water contents are sufficiently high ($\gtrsim 100$ ppm). The distribution of volcanism across the Middle East, Arabia and Africa north of equator suggests that it results from such spoke pattern convection.Leverhulme Trus

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. Antibacterial potency was determined in vitro as minimum inhibitory concentration (MIC) and Mutant Prevention Concentration in broth and pig serum, for six isolates of each organism. For both organisms and for both serum and broth MICs, average concentration:MIC ratios over 48 h were similar and exceeded 2.5:1 and times greater than MIC exceeded 35 h. From in vitro time-kill curves, PK/PD modelling established serum breakpoint values for the index AUC24h/MIC for three levels of inhibition of growth, bacteriostasis and 3 and 4log10 reductions in bacterial count; means were 25.7, 40.2 and 47.0 h, respectively, for P. multocida and 24.6, 43.8 and 58.6 h for A. pleuropneumoniae. Using these PK and PD data, together with literature MIC distributions, doses for each pathogen were predicted for: (1) bacteriostatic and bactericidal levels of kill; (2) for 50 and 90% target attainment rates (TAR); and (3) for single dosing and daily dosing at steady state. Monte Carlo simulations for 90% TAR predicted single doses to achieve bacteriostatic and bactericidal actions over 48 h of 14.4 and 22.2 mg/kg (P. multocida) and 44.7 and 86.6 mg/kg (A. pleuropneumoniae). For daily doses at steady state, and 90% TAR bacteriostatic and bactericidal actions, dosages of 6.2 and 9.6 mg/kg (P. multocida) and 18.2 and 35.2 mg/kg (A. pleuropneumoniae) were required. PK/PD integration and modelling approaches to dose determination indicate the possibility of tailoring dose to a range of end-points

Hints of R-parity violation in B decays into τν\tau \nu

In this article we show that the recently observed enhanced semi-leptonic and leptonic decay rates of the B meson into \tau \nu modes can be explained within the frame work of R-parity violating (RPV) MSSM. In particular, RPV contributions involving the exchange of right-handed down-type squarks give a universal contribution to the B+ --> \tau \nu, B --> D \tau \nu and the B --> D* \tau \nu decays. We find that the masses and couplings that explain the enhanced B decay rates are phenomelogically viable and the squarks can possibly be observed at the LHC.Comment: 8 pages and 3 figures; Updated section 2 and 3, but results are unmodifie

Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency

Introduction: Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency is a major cause. Transduction of uterine arteries in normal or FGR sheep and guinea pigs using an adenovirus (Ad) encoding VEGF isoforms A (Ad.VEGF-A165) and a FLAG-tagged pre-processed short form D (DΔNΔC, Ad.VEGF-DΔNΔC-FLAG) increases endothelial nitric oxide expression, enhances relaxation and reduces constriction of the uterine arteries and their branches. UBF and angiogenesis are increased long term, improving fetal growth in utero. For clinical trial development we compared Ad.VEGF vector transduction efficiency and function in endothelial cells (ECs) derived from different species. Objective: To compare the transduction efficiency and function of the pre-clinical study Ad. constructs (Ad.VEGF-A165, Ad.VEGF-DΔNΔC-FLAG) with the intended clinical trial construct (Ad.VEGF-DΔNΔC) where the FLAG tag is removed. Methods: We infected ECs from human umbilical vein, pregnant sheep uterine artery, pregnant guinea pig aorta and non-pregnant rabbit aorta, with increasing multiplicity of infection (MOI) for 24 or 48 hours of three Ad.VEGF vectors, compared to control Ad. containing the LacZ gene (Ad.LacZ). VEGF supernatant expression was analysed by ELISA. Functional assessment used tube formation assay and Erk-Akt phosphorylation by ELISA. Results: VEGF expression was higher after Ad.VEGF-DΔNΔC-FLAG and Ad.VEGF-DΔNΔC transduction compared to Ad.VEGF-A165 in all EC types (*p<0.001). Tube formation was higher in ECs transduced with Ad.VEGF-DΔNΔC in all species compared to other constructs (***p<0.001, *p<0.05 with rabbit aortic ECs). Phospho-Erk and phospho-Akt assays displayed no differences between the three vector constructs, whose effect was, as in other experiments, higher than Ad.LacZ (***p<0.001). Conclusion: We observed high transduction efficiency and functional effects of Ad.VEGF-DΔNΔC vector with comparability in major pathway activation to constructs used in pre-clinical studies, supporting its use in a clinical trial

Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

PK/PD integration data. (DOCX 7 kb

Australian Sphingidae – DNA Barcodes Challenge Current Species Boundaries and Distributions

© 2014 Rougerie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

Widespread forest vertebrate extinctions induced by a mega hydroelectric dam in lowland Amazonia

Mega hydropower projects in tropical forests pose a major emergent threat to terrestrial and freshwater biodiversity worldwide. Despite the unprecedented number of existing, underconstruction and planned hydroelectric dams in lowland tropical forests, long-term effects on biodiversity have yet to be evaluated. We examine how medium and large-bodied assemblages of terrestrial and arboreal vertebrates (including 35 mammal, bird and tortoise species) responded to the drastic 26-year post-isolation history of archipelagic alteration in landscape structure and habitat quality in a major hydroelectric reservoir of Central Amazonia. The Balbina Hydroelectric Dam inundated 3,129 km2 of primary forests, simultaneously isolating 3,546 land-bridge islands. We conducted intensive biodiversity surveys at 37 of those islands and three adjacent continuous forests using a combination of four survey techniques, and detected strong forest habitat area effects in explaining patterns of vertebrate extinction. Beyond clear area effects, edge-mediated surface fire disturbance was the most important additional driver of species loss, particularly in islands smaller than 10 ha. Based on species-area models, we predict that only 0.7% of all islands now harbor a species-rich vertebrate assemblage consisting of ≥80% of all species. We highlight the colossal erosion in vertebrate diversity driven by a man-made dam and show that the biodiversity impacts of mega dams in lowland tropical forest regions have been severely overlooked. The geopolitical strategy to deploy many more large hydropower infrastructure projects in regions like lowland Amazonia should be urgently reassessed, and we strongly advise that long-term biodiversity impacts should be explicitly included in pre-approval environmental impact assessments

Quantitatively monitoring the resilience of patterned vegetation in the Sahel

This is the final version. Available on open access from Wiley via the DOI in this recordData availability statement: The data that support the findings of this study are openly available in Zenodo. Processed images can be found at https://doi.org/10.5281/zenodo.5536861. Analysis results can be found at https://doi.org/10.5281/zenodo.4050362.Patterning of vegetation in drylands is a consequence of localised feedback mechanisms. Such feedbacks also determine ecosystem resilience - i.e. the ability to recover from perturbation. Hence the patterning of vegetation has been hypothesised to be an indicator of resilience, i.e. spots are less resilient than labyrinths. Previous studies have made this qualitative link and used models to quantitatively explore it, but few have quantitatively analysed available data to test the hypothesis. Here we provide methods for quantitatively monitoring the resilience of patterned vegetation, applied to 40 sites in the Sahel (a mix of previously identified and new ones). We show that an existing quantification of vegetation patterns in terms of a feature vector metric can effectively distinguish gaps, labyrinths, spots, and a novel category of spot-labyrinths at their maximum extent, whereas NDVI does not. The feature vector pattern metric correlates with mean precipitation. We then explored two approaches to measuring resilience. First we treated the rainy season as a perturbation and examined the subsequent rate of decay of patterns and NDVI as possible measures of resilience. This showed faster decay rates - conventionally interpreted as greater resilience - associated with wetter, more vegetated sites. Second we detrended the seasonal cycle and examined temporal autocorrelation and variance of the residuals as possible measures of resilience. Autocorrelation and variance of our pattern metric increase with declining mean precipitation, consistent with loss of resilience. Thus, drier sites appear less resilient, but we find no significant correlation between the mean or maximum value of the pattern metric (and associated morphological pattern types) and either of our measures of resilience.Leverhulme TrustAlan Turing InstituteScience and Technology Facilities Council (STFC

Probing the charged Higgs boson at the LHC in the CP-violating type-II 2HDM

We present a phenomenological study of a CP-violating two-Higgs-doublet Model with type-II Yukawa couplings at the Large Hadron Collider (LHC). In the light of recent LHC data, we focus on the parameter space that survives the current and past experimental constraints as well as theoretical bounds on the model. Once the phenomenological scenario is set, we analyse the scope of the LHC in exploring this model through the discovery of a charged Higgs boson produced in association with a W boson, with the former decaying into the lightest neutral Higgs and a second W state, altogether yielding a b\bar b W^+W^- signature, of which we exploit the W^+W^- semileptonic decays.Comment: 37 pages, 16 figures; v2 updated treatment of LHC constraint

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

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