The Impact of an Event-Triggered Video Intervention on Rural Teenage Driving

This study examines the ability of an event-triggered video system to extend parental involvement into the independent driving phase of newly licensed teen drivers. The system provides both immediate feedback and a 20-second video clip, giving the teen driver and their parent the opportunity to review and learn from their mistakes as well as good responses. The event-triggered video system was placed in the vehicles of 25 teen drivers (ages 16-17) for 57 weeks. The first nine weeks established a within-subject baseline; no parental or system feedback was given during this time. During the next 40 weeks, feedback was provided to the teen driver in the form of a blinking LED on the camera and a weekly report card mailed to the parents. The report showed the driver’s weekly and cumulative performance regarding unsafe behaviors and seatbelt use relative to the other participants. The last eight weeks was a second baseline period. Results revealed two distinct groups: one that triggered few events and one that triggered many events. Combining this emerging technology with parental weekly review of safety-relevant incidents resulted in a significant and lasting decrease in events for most of the teens that triggered many events

SU(6) GUT Breaking on a Projective Plane

We consider a 6-dimensional supersymmetric SU(6) gauge theory and compactify two extra-dimensions on a multiply-connected manifold with non-trivial topology. The SU(6) is broken down to the Standard Model gauge groups in two steps by an orbifold projection (or Wilson line), followed by a Wilson line. The Higgs doublets of the low energy electroweak theory come from a chiral adjoint of SU(6). We thus have gauge-Higgs unification. The three families of the Standard Model can either be located in the 6D bulk or at 4D N=1 supersymmetric fixed points. We calculate the Kaluza-Klein spectrum of states arising as a result of the orbifolding. We also calculate the threshold corrections to the coupling constants due to this tower of states at the lowest compactification scale. We study the regions of parameter space of this model where the threshold corrections are consistent with low energy physics. We find that the couplings receive only logarithmic corrections at all scales. This feature can be attributed to the large N=2 6D SUSY of the underlying model.Comment: Revised versio

Enhanced Symmetries of Orbifolds from Moduli Stabilization

We study a supersymmetric field theory in six dimensions compactified on the orbifold T^2/Z_2 with two Wilson lines. After supersymmetry breaking, the Casimir energy fixes the shape moduli at fixed points in field space where the symmetry of the torus lattice is enhanced. Localized Fayet-Iliopoulos terms stabilize the volume modulus at a size much smaller than the inverse supersymmetry breaking scale. All moduli masses are smaller than the gravitino mass.Comment: 24 pages, 10 figures, Appendix added, matches published versio

Copy number variation genotyping using family information

BACKGROUND: In recent years there has been a growing interest in the role of copy number variations (CNV) in genetic diseases. Though there has been rapid development of technologies and statistical methods devoted to detection in CNVs from array data, the inherent challenges in data quality associated with most hybridization techniques remains a challenging problem in CNV association studies. RESULTS: To help address these data quality issues in the context of family-based association studies, we introduce a statistical framework for the intensity-based array data that takes into account the family information for copy-number assignment. The method is an adaptation of traditional methods for modeling SNP genotype data that assume Gaussian mixture model, whereby CNV calling is performed for all family members simultaneously and leveraging within family-data to reduce CNV calls that are incompatible with Mendelian inheritance while still allowing de-novo CNVs. Applying this method to simulation studies and a genome-wide association study in asthma, we find that our approach significantly improves CNV calls accuracy, and reduces the Mendelian inconsistency rates and false positive genotype calls. The results were validated using qPCR experiments. CONCLUSIONS: In conclusion, we have demonstrated that the use of family information can improve the quality of CNV calling and hopefully give more powerful association test of CNVs

Copy number variation genotyping using family information

Abstract Background In recent years there has been a growing interest in the role of copy number variations (CNV) in genetic diseases. Though there has been rapid development of technologies and statistical methods devoted to detection in CNVs from array data, the inherent challenges in data quality associated with most hybridization techniques remains a challenging problem in CNV association studies. Results To help address these data quality issues in the context of family-based association studies, we introduce a statistical framework for the intensity-based array data that takes into account the family information for copy-number assignment. The method is an adaptation of traditional methods for modeling SNP genotype data that assume Gaussian mixture model, whereby CNV calling is performed for all family members simultaneously and leveraging within family-data to reduce CNV calls that are incompatible with Mendelian inheritance while still allowing de-novo CNVs. Applying this method to simulation studies and a genome-wide association study in asthma, we find that our approach significantly improves CNV calls accuracy, and reduces the Mendelian inconsistency rates and false positive genotype calls. The results were validated using qPCR experiments. Conclusions In conclusion, we have demonstrated that the use of family information can improve the quality of CNV calling and hopefully give more powerful association test of CNVs.http://deepblue.lib.umich.edu/bitstream/2027.42/112374/1/12859_2012_Article_5896.pd

RR parity violation from discrete RR symmetries

We consider supersymmetric extensions of the standard model in which the usual $R$ or matter parity gets replaced by another $R$ or non-$R$ discrete symmetry that explains the observed longevity of the nucleon and solves the $\mu$ problem of MSSM. In order to identify suitable symmetries, we develop a novel method of deriving the maximal $\mathbb{Z}_{N}^{(R)}$ symmetry that satisfies a given set of constraints. We identify $R$ parity violating (RPV) and conserving models that are consistent with precision gauge unification and also comment on their compatibility with a unified gauge symmetry such as the Pati-Salam group. Finally, we provide a counter-example to the statement found in the recent literature that the lepton number violating RPV scenarios must have $\mu$ term and the bilinear $\kappa \, L \, H_u$ operator of comparable magnitude.Comment: v2: references added, minor corrections; matches published version in Nucl. Phys.

Two-dimensional model of dynamical fermion mass generation in strongly coupled gauge theories

We generalize the $N_F=2$ Schwinger model on the lattice by adding a charged scalar field. In this so-called $\chi U\phi_2$ model the scalar field shields the fermion charge, and a neutral fermion, acquiring mass dynamically, is present in the spectrum. We study numerically the mass of this fermion at various large fixed values of the gauge coupling by varying the effective four-fermion coupling, and find an indication that its scaling behavior is the same as that of the fermion mass in the chiral Gross-Neveu model. This suggests that the $\chi U\phi_2$ model is in the same universality class as the Gross-Neveu model, and thus renormalizable and asymptotic free at arbitrary strong gauge coupling.Comment: 18 pages, LaTeX2e, requires packages rotating.sty and curves.sty from CTA

A unique Z_4^R symmetry for the MSSM

We consider the possible anomaly free Abelian discrete symmetries of the MSSM that forbid the mu-term at perturbative order. Allowing for anomaly cancellation via the Green-Schwarz mechanism we identify discrete R-symmetries as the only possibility and prove that there is a unique Z_4^R symmetry that commutes with SO(10). We argue that non-perturbative effects will generate a mu-term of electroweak order thus solving the mu-problem. The non-perturbative effects break the Z_4^R symmetry leaving an exact Z_2 matter parity. As a result dimension four baryon- and lepton-number violating operators are absent while, at the non-perturbative level, dimension five baryon- and lepton-number violating operators get induced but are highly suppressed so that the nucleon decay rate is well within present bounds.Comment: 6 page

Particle Dark Matter - A Theorist's Perspective

Dark matter is presumably made of some new, exotic particle that appears in extensions of the Standard Model. After giving a brief overview of some popular candidates, I discuss in more detail the most appealing case of the supersymmetric neutralino.Comment: Invited talk at PASCOS--03, Mumbai, Indi

Insights Into Child Abuse and Neglect: Findings From The Minnesota Longitudinal Study of Risk and Adaptation

The Minnesota Longitudinal Study of Risk and Adaptation (MLSRA) is a landmark prospective, longitudinal study of human development focused on a sample of mothers experiencing poverty and their firstborn children. Although the MLSRA pioneered a number of important topics in the area of social and emotional development, it began with the more specific goal of examining the antecedents of child maltreatment. From that foundation and for more than 40 years, the study has produced a significant body of research on the origins, sequelae, and measurement of childhood abuse and neglect. The principal objectives of this report are to document the early history of the MLSRA and its contributions to the study of child maltreatment and to review and summarize results from the recently updated childhood abuse and neglect coding of the cohort, with particular emphasis on findings related to adult adjustment. While doing so, we highlight key themes and contributions from Dr Dante Cicchetti\u27s body of research and developmental psychopathology perspective to the MLSRA, a project launched during his tenure as a graduate student at the University of Minnesota