49 research outputs found
Normas preliminares DRIS desarrolladas para caña de azĂșcar a partir de un bajo nĂșmero de muestras
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time, and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space. While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes, vast areas of the tropics remain understudied. In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity, but it remains among the least known forests in America and is often underrepresented in biodiversity databases. To worsen this situation, human-induced modifications may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge, it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%â18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost
Recommended from our members
Study of {alpha}-particle injection effect on superconductors YBa{sub 2}Cu{sub 3}O{sub 7{minus}{delta}} type
Various techniques exist to qualify and quantify this radiation damage effect. The methods are based on destructive methods such as TEM, SEM, CREEP and others. This work is intended to be a starting point to the application of nondestructive techniques to study radiation damage in superconductors in nuclear application, and a creation of a nuclear data bank for different type of materials. The first scheduled nondestructive technique to be applied is positron annihilation, more specifically positron lifetime measurements. This work is based on the implementation of a technique, widely used to simulate neutron radiation effects on materials. This simulation is obtained by the injection of charged particles (ions), from an accelerator, and a beam line equipped with some special experimental arrangement to get a homogeneous distribution of injected particles in the sample. After the ion injection, or neutron damage simulation, the nuclear data are collected by different experimental setups: conventional gamma spectrometer for activation analysis, X-ray diffraction for phase change analysis, and zero detector for magnetic permeability measurements. The behavior of the magnetic permeability with temperature of YBa{sub 2}Cu{sub 3}O{sub 7{minus}{delta}} superconducting ceramics was studied as a function of the amount of He{sup {minus}2} implanted into the sample. With fluence varying from 1.2 to 6.0 {times} 10{sup 6} He{sup {minus}2} cm{sup {minus}2}, the results show that the superconducting temperature T{sub c}(onset) stays nearly constant up to 2.5 {times} 10{sup 6} He{sup {minus}2} cm{sup {minus}2}, decreasing afterwards for higher fluencies. An almost linear decrease is observed for T(offset). The magnetic permeability curves show structures whose shapes and relative positions to T{sub c}(onset) change with the fluence. Although this might indicate a mixture of phases coexisting inside the sample, X-ray diffraction shows no clear evidence for such a pattern. A large percentage of the damage recovers after annealing the He-implanted sample at 673 K