Energetics of ion competition in the DEKA selectivity filter of neuronal sodium channels

The energetics of ionic selectivity in the neuronal sodium channels is studied. A simple model constructed for the selectivity filter of the channel is used. The selectivity filter of this channel type contains aspartate (D), glutamate (E), lysine (K), and alanine (A) residues (the DEKA locus). We use Grand Canonical Monte Carlo simulations to compute equilibrium binding selectivity in the selectivity filter and to obtain various terms of the excess chemical potential from a particle insertion procedure based on Widom's method. We show that K$^{+}$ ions in competition with Na$^{+}$ are efficiently excluded from the selectivity filter due to entropic hard sphere exclusion. The dielectric constant of protein has no effect on this selectivity. Ca$^{2+}$ ions, on the other hand, are excluded from the filter due to a free energetic penalty which is enhanced by the low dielectric constant of protein.Comment: 14 pages, 7 figure

Schwinger, Pegg and Barnett and a relationship between angular and Cartesian quantum descriptions

From a development of an original idea due to Schwinger, it is shown that it is possible to recover, from the quantum description of a degree of freedom characterized by a finite number of states (\QTR{it}{i.e}., without classical counterpart) the usual canonical variables of position/momentum \QTR{it}{and} angle/angular momentum, relating, maybe surprisingly, the first as a limit of the later.Comment: 7 pages, revised version, to appear on J. Phys. A: Math and Ge

Applications systems verification and transfer project. Volume 4: Operational applications of satellite snow cover observations. Colorado Field Test Center

The study was conducted on six watersheds ranging in size from 277 km to 3460 km in the Rio Grande and Arkansas River basins of southwestern Colorado. Six years of satellite data in the period 1973-78 were analyzed and snowcover maps prepared for all available image dates. Seven snowmapping techniques were explored; the photointerpretative method was selected as the most accurate. Three schemes to forecast snowmelt runoff employing satellite snowcover observations were investigated. They included a conceptual hydrologic model, a statistical model, and a graphical method. A reduction of 10% in the current average forecast error is estimated when snowcover data in snowmelt runoff forecasting is shown to be extremely promising. Inability to obtain repetitive coverage due to the 18 day cycle of LANDSAT, the occurrence of cloud cover and slow image delivery are obstacles to the immediate implementation of satellite derived snowcover in operational streamflow forecasting programs

Orthogonal, solenoidal, three-dimensional vector fields for no-slip boundary conditions

Viscous fluid dynamical calculations require no-slip boundary conditions. Numerical calculations of turbulence, as well as theoretical turbulence closure techniques, often depend upon a spectral decomposition of the flow fields. However, such calculations have been limited to two-dimensional situations. Here we present a method that yields orthogonal decompositions of incompressible, three-dimensional flow fields and apply it to periodic cylindrical and spherical no-slip boundaries.Comment: 16 pages, 2 three-part figure

Schwinger, Pegg and Barnett approaches and a relationship between angular and Cartesian quantum descriptions II: Phase Spaces

Following the discussion -- in state space language -- presented in a preceding paper, we work on the passage from the phase space description of a degree of freedom described by a finite number of states (without classical counterpart) to one described by an infinite (and continuously labeled) number of states. With that it is possible to relate an original Schwinger idea to the Pegg and Barnett approach to the phase problem. In phase space language, this discussion shows that one can obtain the Weyl-Wigner formalism, for both Cartesian {\em and} angular coordinates, as limiting elements of the discrete phase space formalism.Comment: Subm. to J. Phys A: Math and Gen. 7 pages, sequel of quant-ph/0108031 (which is to appear on J.Phys A: Math and Gen

Inferential models: A framework for prior-free posterior probabilistic inference

Posterior probabilistic statistical inference without priors is an important but so far elusive goal. Fisher's fiducial inference, Dempster-Shafer theory of belief functions, and Bayesian inference with default priors are attempts to achieve this goal but, to date, none has given a completely satisfactory picture. This paper presents a new framework for probabilistic inference, based on inferential models (IMs), which not only provides data-dependent probabilistic measures of uncertainty about the unknown parameter, but does so with an automatic long-run frequency calibration property. The key to this new approach is the identification of an unobservable auxiliary variable associated with observable data and unknown parameter, and the prediction of this auxiliary variable with a random set before conditioning on data. Here we present a three-step IM construction, and prove a frequency-calibration property of the IM's belief function under mild conditions. A corresponding optimality theory is developed, which helps to resolve the non-uniqueness issue. Several examples are presented to illustrate this new approach.Comment: 29 pages with 3 figures. Main text is the same as the published version. Appendix B is an addition, not in the published version, that contains some corrections and extensions of two of the main theorem

Product rule for gauge invariant Weyl symbols and its application to the semiclassical description of guiding center motion

We derive a product rule for gauge invariant Weyl symbols which provides a generalization of the well-known Moyal formula to the case of non-vanishing electromagnetic fields. Applying our result to the guiding center problem we expand the guiding center Hamiltonian into an asymptotic power series with respect to both Planck's constant $\hbar$ and an adiabaticity parameter already present in the classical theory. This expansion is used to determine the influence of quantum mechanical effects on guiding center motion.Comment: 24 pages, RevTeX, no figures; shortened version will be published in J.Phys.

Embodying prison pain: women’s experiences of self-injury in prison and the emotions of punishment

This paper explores the meanings and motivations of self-injury practices as disclosed in interviews with a small group of female former prisoners in England. In considering their testimonies through a feminist perspective, I seek to illuminate aspects of their experiences of imprisonment that go beyond the ‘pains of imprisonment’ literature. Specifically, I examine their accounts of self-injury with a focus on the embodied aspects of their experiences. In so doing, I highlight the materiality of the emotional harms of their prison experiences. I suggest that the pains of imprisonment are still very much inscribed on and expressed through the prisoner’s body. This paper advances a more theoretically situated, interdisciplinary critique of punishment drawn from medical-sociological, phenomenological and feminist scholarship

Maintenance treatment of renal anaemia in haemodialysis patients with methoxy polyethylene glycol-epoetin beta versus darbepoetin alfa administered monthly: a randomized comparative trial

Background. Several studies with erythropoiesis-stimulating agents claim that maintenance therapy of renal anaemia may be possible at extended dosing intervals; however, few studies were randomized, results varied, and comparisons between agents were absent. We report results of a multi-national, randomized, prospective trial comparing haemoglobin maintenance with methoxy polyethylene glycol-epoetin beta and darbepoetin alfa administered once monthly

A Comparison of Stimulus Set Size on Tact Training for Children with Autism Spectrum Disorder

Previous studies on skill acquisition have taught targets in stimulus sets composed of different numbers of stimuli. Although the rationale for selection of a stimulus set size is not clear, the number of target stimuli trained within a set is a treatment decision for which there is limited empirical support. The current investigation compared the efficiency of tact training in 4 stimulus set sizes, each of which included 12 stimuli grouped into (a) 4 sets of 3 stimuli, (b) 3 sets of 4 stimuli, (c) 2 sets of 6 stimuli, and (d) 1 set of 12 stimuli. Results of all 4 participants with autism spectrum disorder show tact training with larger (i.e., 6 and 12) stimulus set sizes was more efficient than training with smaller (i.e., 3 and 4) stimulus set sizes