Attitudes Toward Mobile Advertising: A Study Of Mobile Web Display And Mobile App Display Advertising

The rapid development of smartphones has resulted in the increasing use of mobile devices to deliver advertisements for products and services. Many firms in Vietnam have invested numerous resources in this field, and an in-depth understanding of mobile advertising is necessary to develop a successful mobile advertising strategy. Based on the existing literature regarding attitudes toward mobile advertising, a questionnaire was constructed to illustrate the factors affecting consumer attitudes toward advertisements on the mobile web and mobile applications. A survey of 206 participants was conducted in this study using the convenience sampling method. The findings of this study show that although many users do not have positive feelings toward advertising, they cannot ignore the importance of mobile advertising. If mobile advertisers can present credibility and entertainment in their advertisements, consumers are willing to view the ads and be influenced to buy products and services. Implications and suggestions for further studies are also provided in this study

Factors influencing the trust of young customers while using e-commerce websites

Internet shopping is now enjoying its prevalence and rapid development in Vietnam. One of factors could be high barrier for this development is consumers’ trust. Lack of trust on websites is a primary reason why many web users do not shop online. This quantitative study is to identify the factors influencing consumers’ trust on websites from the perspective of youths. The proposed model, in this study, is empirically tested using a questionnaire-based field study. A survey of 325 online shoppers has been conducted. Regression analysis is used to test the hypothesis derived from the framework. The result indicates that consumers’ trust on Internet shopping is built on the high level of customers’ perception about the store and company reputation; system quality, and service quality of the website; as well as the effectiveness of third party recognition. Implications and suggestions for further studies were also provided in this study

DARK SOIL PITS AND GRAVES IN VOLCANIC CAVE C6.1, KRONG NO, DAK NONG PROVINCE: DOCUMENTATION AND DISCUSSION

Dark soil pits and graves are critical documents discovered in volcanic cave C6.1. As a result of the investigation and excavation of cave C6.1 conducted in 2017, 2018, and 2019, we have discovered vestiges of nine dark soil pits and seven relatively intact graves, together with teeth and other human remains scattered in the cultural layer. This is an important source of information on the racial composition of the prehistoric inhabitants of the Central Highlands during the Neolithic period, as well as the paleoenvironment, environmental adaptations, and flora and fauna that prehistoric inhabitants exploited for their livelihoods. This article introduces documents and reconstructs the socioeconomic picture of the prehistoric inhabitants of cave C6.1. It also contributes scientific documents for the general conservation and promotion of heritage to develop sustainable cultural tourism in Dak Nong Province

Chemical diversity of essential oils of rhizomes of six species of Zingiberaceae family

In this study, the essential oils from the rhizomes of six species belonging to the Zingiberaceae family, including Zingiber zerumbet, Curcuma pierreana, Globba macrocarpa, Alpinia conchigera, Stahlianthus campanulatus and Amomum sp., collected in Binh Chau-Phuoc Buu Nature Reserve were isolated using hydrodistillation, and their constituents were identified via Gas Chromatography-Mass Spectrometry. A total of 91 constituents have been identified from essential oils. These compounds were classified into 4 clusters by Agglomerative Hierarchical Clustering (AHC) and Principal Component Analysis (PCA) analysis. The principal constituents of the essential oils isolated from four species, C. pierreana, S. campanulatus, A. conchigera, and Z. zerumbet contained camphene (18.82%), α-copaene (11.75%), p-xylene (21.86%), and α-santalene (17.91%), which were significantly different from those in previous reports. Furthermore, this study revealed the chemical constituents of essential oils of G. macrocarpa and Amomum sp. for the first time. Accordingly, artemisia triene (22.21%), β-pinene (13.57%), 4,6,8-trimethylazulene (11.1%), 2-tert-butylquinoline (9.86%), β-patchoulene (7.06%), α-elemene (6.93%), and β-ocimene (6.0%) were the major compounds in essential oils of G. macrocarpa rhizomes whereas the oil of Amomum sp. was found to be rich in 2-carene (21.82%), fenchyl acetate (14.26%), 3-carene (8.28%), bornyl acetate (7.7%), and D-limonene (7.13%)

When Intervention Becomes Imperative: A Case Report of Spontaneous Vulvar Edema During Pregnancy

Spontaneous idiopathic vulvar edema during the second trimester is a rare condition. The approach to managing this condition involves relieving symptoms, identifying underlying causes, and implementing appropriate treatment. Managing such cases during pregnancy is challenging because of concerns for potential adverse fetal outcomes. Conservative management expects the condition to be relieved spontaneously postpartum, whereas invasive treatment offers a more rapid resolution. Treatment choices are controversial because each method has its pros and cons and influences the delivery process to a certain extent. Surgical drainage becomes a viable option when patients are not responsive to medications. We report a case of spontaneous massive vulvar edema in a 22-year-old primigravida in her 23rd week of pregnancy. After ruling out other notable causes of vulvar edema, we decided to intervene using an invasive procedure because she complained of progressive symptoms and discomfort. Subsequently, the edema subsided postprocedure, and the patient experienced successful labor with no complications. This report aims to alert clinicians that drainage attempts should be considered in pregnant patients with worsening symptoms

Synthesis of microcrystalline cellulose from banana pseudo-stem for adsorption of organics from aqueous solution

In this study, we proposed and tested a green method for producing microcrystalline cellulose (MCC) with high quality from waste banana pseudo-stem (BPS) after fruit harvesting. The MCC was synthesized by treating BPS with sulfuric acid, sodium hydroxide, and H2O2solution.The produced MCC material was then characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis to explore its properties. The removal of methylene blue (MB) in aqueous solution was conducted by batch adsorption method to evaluate the applicability of MCC for wastewater treatment. The results showed that the adsorption using MCC reached equilibrium after 15 min. The highest MB adsorption capacity of MCC reached 16.6mg/g at pH 6. The adsorption kinetics data were best described by the pseudo second order rate equation. Equilibrium isotherm data of adsorption were well fitted to the linear Langmuir isotherm model. Affecting factors such as adsorbent dosage, initial concentration of MB, and temperature were also investigated. These results suggest a great potential use of MCC for advanced wastewater treatment

Research to support and inform the development, implementation and/or evaluation of tobacco control policies in relation to the framework convention on tobacco control in low and middle-income countries

In order to enforce policies on tobacco control in Vietnam, reliable information on health and socio-economic hazards associated with tobacco farming is needed. The study investigates the harmful impact of tobacco cultivation and processing on health of tobacco farmers in a rural community in northern Vietnam. Objectives included estimation of health care costs as well as health beliefs related to tobacco cultivation and processing. The health of those who cultivate the crop is constantly put in peril. The study confirms that tobacco farming does not bring prosperity to the farmers while causing them a lot of health problems, especially among women

Mapping for engagement: setting up a community based participatory research project to reach underserved communities at risk for Hepatitis C in Ho Chi Minh City, Vietnam

Background: Approximately 1. 07 million people in Vietnam are infected with hepatitis C virus (HCV). To address this epidemic, the South East Asian Research Collaborative in Hepatitis (SEARCH) launched a 600-patient cohort study and two clinical trials, both investigating shortened treatment strategies for chronic HCV infection with direct-acting antiviral drugs. We conducted ethnographic research with a subset of trial participants and found that the majority were aware of HCV infection and its implications and were motivated to seek treatment. However, people who inject drugs (PWID), and other groups at risk for HCV were under-represented, although injecting drug use is associated with high rates of HCV. Material and Methods: We designed a community-based participatory research (CBPR) study to engage in dialogues surrounding HCV and other community-prioritized health issues with underserved groups at risk for HCV in Ho Chi Minh City. The project consists of three phases: situation analysis, CBPR implementation, and dissemination. In this paper, we describe the results of the first phase (i.e., the situation analysis) in which we conducted desk research and organized stakeholder mapping meetings with representatives from local non-government and community-based organizations where we used participatory research methods to identify and analyze key stakeholders working with underserved populations. Results: Twenty six institutions or groups working with the key underserved populations were identified. Insights about the challenges and dynamics of underserved communities were also gathered. Two working groups made up of representatives from the NGO and CBO level were formed. Discussion: Using the information provided by local key stakeholders to shape the project has helped us to build solid relationships, give the groups a sense of ownership from the early stages, and made the project more context specific. These steps are not only important preliminary steps for participatory studies but also for other research that takes place within the communities

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Development of novel chemically-modified splice-modulating antisense oligonucleotides for tackling Duchenne muscular dystrophy and solid cancers

Antisense oligonucleotides (AOs) are a class of nucleic acid molecule that can specifically bind to RNA targets and subsequently modulate gene expression by different mechanisms of action. AOs composed of natural nucleotide monomers are not suitable for clinical applications as they are vulnerable to nuclease degradation and possess relatively low target binding affinity. To overcome these impediments, chemically-modified nucleic acid analogues are used to improve AO resistance to nuclease degradation, and target binding affinity. AO-mediated splice modulation has been emerged as a potential treatment approach for different genetic diseases, especially in Duchenne muscular dystrophy (DMD)- an X-linked inherited recessive condition arising from protein-truncating mutations in the dystrophin gene. By blocking the interaction between splicing factors and pre-mRNA, AOs can be used to correct genetic defects by manipulating splicing (exon deletion or inclusion). This thesis explores the synthesis and screening of various chemically-modified splice-modulating AOs in different cellular models. Chapter 1 provides a broad overview of various nucleic acid therapeutic technologies and the significance of chemically-modified oligonucleotides in drug development. Chapter 2 focused on the evaluation of various chemically-modified nucleotide-modified exon-skipping AOs in DMD. For this purpose, AOs incorporated with various chemically-modified analogues were designed, synthesised and tested their ability to induce exon-23 skipping in mouse dystrophin gene transcript in vitro. The focus of Chapter 3 was to develop novel splice-modulating AOs targeting Vascular Endothelial Growth Factor (VEGF) towards tackling solid cancers. VEGF is a key regulator in angiogenesis- a process that implicated with cancer development, and in this study we developed novel splice-modulating AOs to inhibit the expression of VEGF and evaluated their efficacy in different cancer cells in vitro. Overall, the findings in this thesis show promising potential of chemically-modified nucleic acid analogues in developing splice-modulating AOs. The results presented here highlight the scope of chemically-modified splice-modulating AOs towards developing efficient therapeutic molecules in tackling various diseases