Characterisation of T cell defects in acute myeloid leukaemia

PhDUnderstanding the immune system in patients with cancer and how it interacts with malignant cells is critical for the development of successful immunotherapeutic strategies at a time when novel cancer treatment approaches are required. Acute myeloid leukaemia (AML) results in widespread interaction between the malignant cells and T cells and as such, offers an opportunity to study these interactions. A flow cytometric analysis of T cells in the peripheral blood of patients presenting with AML illustrated that the absolute number of T cells is increased in AML compared with healthy controls. Furthermore, a large population of CD3+56+ cells was identified. These cells are not natural killer T cells but effector T cells that may represent a failing immunosurveillance mechanism. Two technical issues were explored: how to separate T cells from the peripheral blood of newly diagnosed AML patients and the impact of the method of immunomagnetic cell separation on the gene expression profile of healthy T cells. Gene expression profiling was subsequently performed on T cells from AML patients compared with healthy controls. Global differences in transcription were observed suggesting aberrant T cell activation patterns in AML. As differentially regulated genes involved in actin cytoskeletal formation were noted, a functional assessment of the ability of T cells from AML patients to form immunological synapses was performed. This illustrated that although T cells from AML patients can form conjugates with autologous blasts, their ability to form immune synapses and recruit phosphotyrosine signalling molecules to that signalling interface is impaired. Taken together, these findings demonstrate that numerically T cells are plentiful in AML however they are abnormal in terms of the genes they are transcribing and in their interactions with tumour cells. Targeting immunological synapse formation may represent an important means of improving T cell recognition of tumour cells across a range of cancers

Study of LaSiO3Cl:Ce3+,Tb3+ and Ca5B2SiO10:Eu3+ Phosphors for Improving Hue Standard and Illuminating Beam of WLEDs

Remote phosphor arrangements usually have low color quality and superior lumen output to that of conformal phosphor arrangements and in-cup phosphor arrangements. For this reason, many researches are done so that we could enhance the chromatic quality for the remote phosphor arrangements. For this research, we are suggesting the double-layer remote phosphor arrangement to boost the CRI (short for color rendering index) as well as the CQS (short for color quality scale) in WLED devices. Three identical WLED arrangements which have dissimilar chromatic temperature which covers 5600 K, 8500 K will be used in this paper. The initial idea involves placing one sheet of blue phosphor LaSiO3Cl:Ce3+,Tb3+ or one sheet of red phosphor Ca5B2SiO10:Eu3+ over a sheet of yellow phosphor YAG:Ce3+. After that, seek an appropriate concentration of Ca5B2SiO10:Eu3+ so that we could obtain the most desirable chromatic performance. Judging the result, the element Ca5B2SiO10:Eu3+ seem to help improve the CRI and CQS levels. Particularly, the greater the concentration of La2O3:Eu3+ is, the greater level the CRI and the CQS will get, because of the boost in red illumination within the WLED devices. In addition, the blue phosphor layer LaSiO3Cl:Ce3+,Tb3+ helps increase the lumen output. But the decline of the lumen as well as the chromatic performance manifests if the concentration of LaSiO3Cl:Ce3+,Tb3+ and Ca5B2SiO10:Eu3+ is beyond required level. This is demonstrated by utilizing the theory of Mie-scattering as well as the law of Beer–Lambert. This research’s result is important for the augmentation of white light performance in the WLED devices

A STUDY ON THE DIFFICULTIES ENCOUNTERED BY SENIOR STUDENTS OF ENGLISH IN WRITING ESSAY TASK 2

This study focuses on understanding the obstacles encountered by senior students at FE-UFLS-UD when writing task 2 of the C1.2 End-of-Course Test, along with the factors contributing to these challenges and proposed remedies. Data was gathered from 42 students who studied in the C1.2 Writing subject and took the C1.2 End-of-Course Test. The study employed an open-ended questionnaire and semi-structured interviews, the study employed thematic coding and qualitative methods to analyze the collected data, revealing the presence of affective, cognitive, and linguistic difficulties and their underlying causes. Based on these findings, the study offers recommendations to address these issues. Importantly, the research encourages students to utilize the insights gained from the study to enhance their study approaches and prepare for both the C1.2 End-of-Course Test and the VSTEP exam. Additionally, teachers can take the findings as guidance to assist students to improve their writing skills effectively.  Article visualizations

Factors Affecting Youtube Acceptance For Student Learning Needs

This study was conducted to demonstrate the factors that influence Vietnamese students’ acceptance of YouTube for educational purposes. Qualitative and quantitative research methods are combined to test the research hypotheses. Research data was collected using quota sampling, with a sample size of 306 students studying at universities in Vietnam. Structural equation modeling (SEM) helps demonstrate that five factors positively affect the intention to use YouTube for student learning needs. These factors include performance expectancy, effort expectancy, hedonic motivation, social influence, and flexibility. Furthermore, research has demonstrated the positive impact of intentional use on the behavioral usage of YouTube for the educational requirements of Vietnamese students. The study provides a valuable reference for educational administrators and researchers

Application of CaTiO3:Pr3+ Phosphor for Enhancing the Hue Standard of WLEDs with Double-Film Distant Phosphor Structure

Due to its great thermal stability, the WLEDs (short for white-light diodes), which are made of PiG (short for phosphor-in-glass), appear to be an optical source most effective at generating potent white illumination. However, the actual applications they offer are limited by their poor color rendering and color uniformity. To improve the color rendering and uniformity, this study suggested utilizing a configuration involving a PiG-RPL (short for PiG integrated with a lens of phosphor in red). The phosphor YAGG (also known as Y3Al3.08Ga1.92O12:Ce3+) and borosilicate glass powders were printed, then sintered to generate the green PiG, and then using an inverted dispensing approach, we applied the CASN phosphor silicone in red color (also known as CaAlSiN3:Eu2+) to the said PiG. As a result, with a current of 350 mA, the WLEDs made of PiG-RPL exhibit highly remarkable chromatic performance for the CRI (also known as color rendering index) values determined as Ra = 95.6 with R9 = 95.2 and fidelity/gamut values determined as Rf = 92 with Rg = 99.2. The color quality of the PiG-RPL based WLEDs is steady over a wide range of currents, from 100 to 1000 mA. Moreover, PiG-RPL based WLEDs have better color uniformity than typical PiG based WLEDs. The PiG-RPL structure was proposed in this paper to improve the WLEDs’ chromatic generation as well as chromatic homogeneity. We made the PiGRPL via placing a lens of CASN phosphor above a PiG in green color made of YAGG phosphor. For WLEDs, the PiG-RPL provides extremely remarkable chromatic generation. Furthermore, the WLEDs that are made of PiG-RPL have better color uniformity than those made of PiG and PiG-RPP. The PiG-RPL color converters are considered to be promising for high-power WLEDs, offering great color rendering and color uniformity

Trust in an online hospitality network : An interpretive study of The CouchSurfing Project

The aim of this interpretive study is to acquire a deeper understanding of the concept of interpersonal trust in an online community, namely, The CouchSurfing Project. CouchSurfing is an online hospitality network whose purpose is to connect travellers and local hosts offering free accommodations and more importantly, a chance for cultural exchange. CouchSurfers complete online profiles that allow other members to search for and make requests for accommodations based on information on these profiles. In the discombobulated virtual environment, online personas might not reflect reality. Issues of trust and the perceived risks associated with CouchSurfing were explored. The concepts of trust and risk share a close relationship; in order to build trust, it is necessary to minimise the perceived risks. Semi-structured interviews were conducted with 6 CouchSurfing members and 6 nonmembers. Non-members were included in this study in order to obtain a perspective that would be different from those who already prescribe to the CouchSurfing philosophy that is based on the concept of “paying it forward.” Both members and non-members acknowledged that there are risks to participating in CouchSurfing. However, strategies such as control, comparison between risks, possession of self-confidence and scapegoating seem to help mitigate perceived risks. Moreover, this study suggests that the community’s social network acts as an informal method of social control to help foster and sustain trust amongst its members. Thus, it is the human relationships, rather than technologies that are important in nurturing trust.Joint Master Degree in Digital Library Learning (DILL

The linear invariants (dn ) and (Ω) for spaces of germs of holomorphic functions on compact subsets of Cn

For a compact subset K of Cn, we give necessary and sufficient conditions for [H(K)]0 to have the property (DN), and similarly for the property (Ω). We also show that H(D) is isomorphic to H(∆ n), where ∆n is the unit polydisc in Cn and D is any bounded Reinhardt domain in Cn. This last result requires a generalization of the classical Hartogs phenomenon

Treatment of Fractures in Black Africa: The Current State of Play

Editorial Comment by Dr. Packo Dieu-le-veut Saint-Cyr Sylvestre, Member, International Editorial Board, IHRJ and Dr. Feigoudozoui Hermann Victoir

The local uniform convergence of positive harmonic function sequence

The Harnack distance on space  and its conformal invariance were constructed and studied by Herron. In this paper, we obtain the Harnack distance on domains  in . Then, we use this concept to investigate some properties of the positive harmonic function class. These results are obtained in the complex plane, so it is advantageous to take some tools of the complex analysis. The main result of this paper is the property of the local uniform convergence of the positive harmonic sequences on a domain in the complex plane.The Harnack distance on space  and its conformal invariance were constructed and studied by Herron. In this paper, we obtain the Harnack distance on domains  in . Then, we use this concept to investigate some properties of the positive harmonic function class. These results are obtained in the complex plane, so it is advantageous to take some tools of the complex analysis. The main result of this paper is the property of the local uniform convergence of the positive harmonic sequences on a domain in the complex plane