Infraestructura complementaria a sede social Poblacion La Obra.

30 p.Existencia de la Población La Obra y la carencia de un espacio publico. Aparece la idea de configurar este espacio para fomentar las actividades que no tienen lugar para desarrollarse y a la vez dar cabida a nuevas actividades. Solo existe una sede social y el terreno donde se emplaza como le lugar potencial de intervención. No existe un financiamiento, solo mano de obra y algunas posibilidades de donaciones. Comienza la gestión de los posibles materiales paralelo al diseño. La idea principal es crear una estructura complementaria a lo existente para que las actividades se desarrollen de mejor manera y exista una mejor ocupación del terreno. Tanto para estas actividades, futuras nuevas actividades como para el uso diario. Se concretan las distintas donaciones por parte de madereras, empresas, privados, etc. Y junto con el diseño aprobado comienza la construcción de este proyecto. Con el esfuerzo y organización de los habitantes de la Población La Obra es posible concretar y finalizar la construcción y las intenciones que se pretendían con esta intervención

Functional Lateralization of Temporoparietal Junction: Imitation Inhibition, Visual Perspective Taking and Theory of Mind.

Although neuroimaging studies have consistently identified the temporoparietal junction (TPJ) as a key brain region involved in social cognition, the literature is far from consistent with respect to lateralization of function. For example, bilateral TPJ activation is found during theory of mind tasks in some studies, but only right hemisphere activation in others. Visual perspective taking and imitation inhibition, which have been argued to recruit the same socio-cognitive processes as theory of mind, are associated with unilateral activation of either left TPJ (perspective taking), or right TPJ (imitation inhibition). The present study investigated the functional lateralization of TPJ involvement in the above three socio-cognitive abilities using transcranial direct current stimulation. Three groups of healthy adults received anodal stimulation over right TPJ, left TPJ or the occipital cortex prior to performing three tasks (imitation inhibition, visual perspective taking and theory of mind). In contrast to the extant neuroimaging literature, our results suggest bilateral TPJ involvement in imitation inhibition and visual perspective taking, while no effect of anodal stimulation was observed on theory of mind. The discrepancy between these findings and those obtained using neuroimaging highlight the efficacy of neurostimulation as a complementary methodological tool in cognitive neuroscience. This article is protected by copyright. All rights reserved

Using conceptual modeling to improve genome data management

[EN] With advances in genomic sequencing technology, a large amount of data is publicly available for the research community to extract meaningful and reliable associations among risk genes and the mechanisms of disease. However, this exponential growth of data is spread in over thousand heterogeneous repositories, represented in multiple formats and with different levels of quality what hinders the differentiation of clinically valid relationships from those that are less well-sustained and that could lead to wrong diagnosis. This paper presents how conceptual models can play a key role to efficiently manage genomic data. These data must be accessible, informative and reliable enough to extract valuable knowledge in the context of the identification of evidence supporting the relationship between DNA variants and disease. The approach presented in this paper provides a solution that help researchers to organize, store and process information focusing only on the data that are relevant and minimizing the impact that the information overload has in clinical and research contexts. A case-study (epilepsy) is also presented, to demonstrate its application in a real context.Spanish State Research Agency and the Generalitat Valenciana under the projects TIN2016-80811-P and PROMETEO/2018/176; ERDF.Pastor López, O.; León-Palacio, A.; Reyes Román, JF.; García-Simón, A.; Casamayor Rodenas, JC. (2020). Using conceptual modeling to improve genome data management. Briefings in Bioinformatics. 22(1):45-54. https://doi.org/10.1093/bib/bbaa100S4554221McCombie, W. R., McPherson, J. D., & Mardis, E. R. (2018). Next-Generation Sequencing Technologies. Cold Spring Harbor Perspectives in Medicine, 9(11), a036798. doi:10.1101/cshperspect.a036798Condit, C. M., Achter, P. J., Lauer, I., & Sefcovic, E. (2001). The changing meanings of ?mutation:? A contextualized study of public discourse. Human Mutation, 19(1), 69-75. doi:10.1002/humu.10023Karki, R., Pandya, D., Elston, R. C., & Ferlini, C. (2015). Defining «mutation» and «polymorphism» in the era of personal genomics. BMC Medical Genomics, 8(1). doi:10.1186/s12920-015-0115-zHamid, J. S., Hu, P., Roslin, N. M., Ling, V., Greenwood, C. M. T., & Beyene, J. (2009). Data Integration in Genetics and Genomics: Methods and Challenges. Human Genomics and Proteomics, 1(1). doi:10.4061/2009/869093Baudhuin, L. M., Biesecker, L. G., Burke, W., Green, E. D., & Green, R. C. (2019). Predictive and Precision Medicine with Genomic Data. Clinical Chemistry, 66(1), 33-41. doi:10.1373/clinchem.2019.304345Amaral, G., & Guizzardi, G. (2019). On the Application of Ontological Patterns for Conceptual Modeling in Multidimensional Models. Lecture Notes in Computer Science, 215-231. doi:10.1007/978-3-030-28730-6_14Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., … Sherlock, G. (2000). Gene Ontology: tool for the unification of biology. Nature Genetics, 25(1), 25-29. doi:10.1038/75556Eilbeck, K., Lewis, S. E., Mungall, C. J., Yandell, M., Stein, L., Durbin, R., & Ashburner, M. (2005). Genome Biology, 6(5), R44. doi:10.1186/gb-2005-6-5-r44Vihinen, M. (2013). Variation Ontology for annotation of variation effects and mechanisms. Genome Research, 24(2), 356-364. doi:10.1101/gr.157495.113Köhler, S., Carmody, L., Vasilevsky, N., Jacobsen, J. O. B., Danis, D., Gourdine, J.-P., … McMurry, J. A. (2018). Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources. Nucleic Acids Research, 47(D1), D1018-D1027. doi:10.1093/nar/gky1105Proceedings of the Eleventh International Conference on Data Engineering. (1995). Proceedings of the Eleventh International Conference on Data Engineering. doi:10.1109/icde.1995.380416Okayama, T., Tamura, T., Gojobori, T., Tateno, Y., Ikeo, K., Miyazaki, S., … Sugawara, H. (1998). Formal design and implementation of an improved DDBJ DNA database with a new schema and object-oriented library. Bioinformatics, 14(6), 472-478. doi:10.1093/bioinformatics/14.6.472Medigue, C., Rechenmann, F., Danchin, A., & Viari, A. (1999). Imagene: an integrated computer environment for sequence annotation and analysis. Bioinformatics, 15(1), 2-15. doi:10.1093/bioinformatics/15.1.2Paton, N. W., Khan, S. A., Hayes, A., Moussouni, F., Brass, A., Eilbeck, K., … Oliver, S. G. (2000). Conceptual modelling of genomic information. Bioinformatics, 16(6), 548-557. doi:10.1093/bioinformatics/16.6.548Vihinen, M., Hancock, J. M., Maglott, D. R., Landrum, M. J., Schaafsma, G. C. P., & Taschner, P. (2016). Human Variome Project Quality Assessment Criteria for Variation Databases. Human Mutation, 37(6), 549-558. doi:10.1002/humu.22976Fleuren, W. W. M., & Alkema, W. (2015). Application of text mining in the biomedical domain. Methods, 74, 97-106. doi:10.1016/j.ymeth.2015.01.015Salzberg, S. L. (2007). Genome re-annotation: a wiki solution? Genome Biology, 8(1). doi:10.1186/gb-2007-8-1-102Rigden, D. J., & Fernández, X. M. (2018). The 26th annual Nucleic Acids Research database issue and Molecular Biology Database Collection. Nucleic Acids Research, 47(D1), D1-D7. doi:10.1093/nar/gky1267Reyes Román, J. F., García, A., Rueda, U., & Pastor, Ó. (2019). GenesLove.Me 2.0: Improving the Prioritization of Genetic Variations. Evaluation of Novel Approaches to Software Engineering, 314-333. doi:10.1007/978-3-030-22559-9_14Richards, S., Aziz, N., Bale, S., Bick, D., Das, S., … Rehm, H. L. (2015). Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genetics in Medicine, 17(5), 405-423. doi:10.1038/gim.2015.30Kelly, M. A., Caleshu, C., Morales, A., Buchan, J., Wolf, Z., … Funke, B. (2018). Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen’s Inherited Cardiomyopathy Expert Panel. Genetics in Medicine, 20(3), 351-359. doi:10.1038/gim.2017.21

Towards the Understanding of the Human Genome: A Holistic Conceptual Modeling Approach

[EN] Understanding the human genome is a great scientific challenge, whose achievement requires effective data manipulation mechanisms. The non-stop evolution of both new knowledge and more efficient sequencing technologies generates a kind of genome data chaos. This chaos complicates the use of computational resources that obtain data and align them into specific actions. Conceptual model-based techniques should play a fundamental role in turning data into actionable knowledge. However, current solutions do not give a crucial role in the task of modeling that it should have to obtain a precise understanding of this domain. Hundreds of different data sources exist, but they have heterogeneous, imprecise, and inconsistent data. It is remarkably hard to have a unified data perspective that covers the genomic data from genome to transcriptome and proteome, which could facilitate semantic data integration. This paper focuses on how to design a conceptual model of the human genome that could be used as the key artifact to share, integrate, and understand the various types of datasets used in the genomic domain. We provide a full conceptual picture of relevant data in genomics and how semantic data integration is much more effective by conceptually integrating the diverse types of existing data. We show how such a conceptual model has been built, focusing on the conceptual problems that were solved to adequately model concepts whose knowledge is under constant evolution. We show how the use of the initial versions of the conceptual model in practice has allowed us to identify new features to incorporate in the model, achieving a continuous improvement process. The current version is ready to be used as the key artifact in projects where conceptually combining multiple levels of data helps to provide valuable insights that would be hard to obtain without it.This work was supported in part by the Spanish State Research Agency, in part by the Generalitat Valenciana under Grant TIN2016-80811-P and Grant PROMETEO/2018/176, and in part by European Regional Development Fund (ERDF).García-Simón, A.; León-Palacio, A.; Reyes Román, JF.; Casamayor Rodenas, JC.; Pastor López, O. (2020). Towards the Understanding of the Human Genome: A Holistic Conceptual Modeling Approach. IEEE Access. 8:197111-197123. https://doi.org/10.1109/ACCESS.2020.3034793S197111197123

Sustainable wastewater treatment plants design through multiobjective optimization

Nowadays, an adequate design of wastewater treatment plants taking into consideration ail sustainability dimensions- economic, environmental and social- is fundamental. This can be achieved by implementing systematic methodologies where conceptual and mathematical tools can be used together. This contribu­tion proposes a framework that uses total cost, consumed energy, and reclaimed wastewater as sustain­ability metrics. A mixed-integer nonlinear programming problem arises from a general superstructure for wastewater treatment plants. A case study from Mexico City is solved by a hybrid multiobjective opti­mization approach that combines lexicographie and e-constraint methods. Solutions are provided in the form of a Pareto front. A modified technique for order of preference by similarity to ideal solution (M­TOPSIS) analysis is used as a multiple criteria decision-making tool to find the best trade-off solution. The optimal sustainable configuration resulted consists of three levels of treatment and 100% of treated water reuse

Refugio para Arrieros Cajon del Melado, Maule - Chile

43 p.El Cajón del Melado, situado en Ia cordillera de Ia región del Maule, alberga una comunidad que acoge 55 familias. Por su posicionamiento geográfico los habitantes desarrollan una economía interna e independiente, en donde los actores de este sistema son casi exclusivamente los mismos habitantes, viéndose interrumpidos por inversionistas externos, que transforman el paisaje y aportan cambios en el oficio a través de una nueva economía. De esta manera el proyecto Ilega a dar soporte a una de las actividades fundamentales del lugar, involucrando el paisaje y el oficio en distintos niveles que atraerían a diversos personajes dentro de la comunidad. El arriero, personaje característico del oficio propio de Ia zona, logra conectar las distintas coordenadas que conforman esta economía local, dando vida también a situaciones espaciales tácitas para el habitante y generando a la vez la problemática de crear un soporte para la detención en Ia huella del arriero. Dentro de este marco, el proyecto Ilega a sustentar Ia detención necesaria en la ruta, posándose en el paisaje de una manera en que tanto materia como manera constructiva más que irrumpir en el fondo cordillerano, dejan de funcionar como bloque para volverse transparentes y sumarse al paisaje

Resting-state functional connectivity and socioemotional processes in male perpetrators of intimate partner violence against women

Intimate partner violence against women (IPVAW) is a serious and overwhelming public concern. Neuroimaging techniques have provided insights into the brain mechanisms underlying IPVAW perpetration. The purpose of this study is to examine the resting-state functional connectivity (rsFC) involving the process of social decision-making of male perpetrators. Twenty-six male perpetrators convicted for an IPVAW crime were compared to 29 men convicted for crimes other than IPVAW (other offenders) and 29 men with no criminal records (non-offenders) using a seed-based approach. Seeds were located in areas involved in reflective (prefrontal), impulsive (amygdala and striatum) and interoceptive (insula) processing. Then, as an exploratory analysis, the connectivity networks on male perpetrators were correlated with measures of executive functions and socioemotional self-report measures. Male perpetrators in comparison to other offenders and non-offenders, presented higher rsFC between prefrontal, limbic, brainstem, temporal and basal ganglia areas. Also male perpetrators showed higher rsFC between insula, default mode network and basal ganglia, while lower rsFC was found between prefrontal and motor areas and between amygdala, occipital and parietal areas. Exploratory correlations suggest that the specific rsFC in male perpetrators might be more related to socioemotional processes than to executive functions. These results showed that male perpetrators present a specific rsFC in brain systems that are essential for an adaptive social decision-making

La práctica aleatoria frente a la enseñanza sin errores en el aprendizaje del putt de golf en adolescentes

Although learning golf putting has been the subject of numerous studies, in the adolescent age group there are very few references on how to design a learning process that has the appropriate challenge gradient and difficulty in physical education (PE) learning environments. The aim of this study was to investigate through an ecological approach, whether random practice (variability) facilitates learning golf putting in the initiation phase as well as error-free learning (repetition). A total of 46 students (M=13.8±.07 years) in the second year of compulsory secondary education (ESO) participated in the study. None of the participants had previous experience playing golf. The following assessments were undertaken: a) pretest, b) intervention, consisting of seven practice blocks of 10 repetitions, c) posttest and d) transfer test (two weeks after the posttest). The data indicate that both the random learning group (variability) and the error-free learning group achieved similar results in the posttest (M=1.36, SD=0.32 versus M=1.16 SD=0.30), and in the transfer test (M=2.56, SD=0.07 versus M=2.53, SD= 0.07). Learning complex technical movements such as golf putting is possible for adolescents in the initiation phase. Both random practice and error reduction provide a similar degree of learning in the short and long term.El aprendizaje del putt de golf ha sido objeto de múltiples estudios, si bien en la franja de edad de la adolescencia apenas hay referencias de cómo plantear un proceso de aprendizaje que tenga el gradiente de desafío y la dificultad adecuada en contextos de aprendizaje en Educación Física (EF). Purpose: El objetivo de este estudio es investigar mediante una aproximación ecológica, si la práctica aleatoria (variabilidad) permite el aprendizaje del putt de golf en la iniciación deportiva al igual que el aprendizaje sin errores (repetitivo). Método: Han participado 46 estudiantes (M=13.8±.07años) de segundo curso de la enseñanza secundaria obligatoria (ESO), sin ninguna experiencia previa en este deporte. Se han tomado varias mediciones: a) pretest, b) tratamiento, consistente en siete bloques de práctica de 10 repeticiones, c) post-test y d) test de transferencia (dos semanas después del post-test). Resultados: Los datos nos indican que tanto el grupo de aprendizaje aleatorio (variabilidad) como el grupo de aprendizaje sin errores consiguen resultados parecidos tanto en el post-test (M=1,36, SD=0,32 vs M= 1,16 SD=0,30), como en el test de transferencia (M=2,56, SD=0,07 vs M=2,53, SD= 0,07). Conclusión: El aprendizaje de un gesto técnico tan complejo como es el putt de golf puede plantearse en estas edades y en la fase de iniciación tanto desde la variabilidad de la práctica como mediante la reducción del error y con una manifestación del nivel de aprendizaje parecido a corto y largo plazo

Sevoflurane Sedation Protocol in Children with Cerebral Palsy Undergoing BotulinumToxin-A Injections

Objetivo: Describir nuestra experiencia con un protocolo basado en el uso de sevoflurano para la sedación y analgesia durante la infiltración de Toxina Botulínica tipo A (BoNT-A) en niños con parálisis cerebral (PC), especialmente en términos de seguridad y efectividad. Material y Métodos: Estudio observacional retrospectivo de pacientes con PC a los que se realizó infiltración con BoNT-A bajo sedación con sevoflurano desde noviembre de 2012 hasta diciembre de 2019. Se revisaron las características demográficas, las características clínicas y funcionales, la efectividad de la sedación, los eventos adversos (EA) y la satisfacción del profesional. Resultados: se realizaron 387 sedaciones en 74 pacientes diagnosticados de PC. La sedación efectiva se logró en el 100% de los procedimientos, facilitando la colaboración durante la infiltración y la satisfacción del profesional. Se notificaron EA en el 6,02% de los procedimientos, siendo las más frecuentes las náuseas y los vómitos (3,88%) y la hipoxemia transitoria (2,07%). No se informaron EA graves. No se encontró asociación entre la incidencia de EA y las variables clínicas, funcionales o el riesgo antes de la anestesia. Conclusiones: La sedación con sevoflurano muestra resultados prometedores en términos de seguridad y efectividad para el manejo de la agitación y el dolor durante la infiltración de BoNT-A en nuestra práctica clínica diaria. Además, puede facilitar la infiltración, permitir la exploración bajo sedación e infiltración multinivel con buena tolerancia.Objective: This study aimed to describe our experience with a protocol based on sevoflurane sedation to control pain and agitation during botulinum toxin-A (BoNT-A) infiltration in children with cerebral palsy (CP), especially in terms of safety and efficacy. Material and methods: We conducted a retrospective observational study of patients diagnosed with CP who underwent BoNT-A infiltration with sevoflurane sedation from November 2012 to December 2019. Demographic, clinical and functional characteristics, the effectiveness of sedation, adverse events (AE) and professional satisfaction were reviewed. Results: A total of 387 sedations were successfully performed in 74 patients. Effective sedation was achieved in 100% of procedures, facilitating collaboration during infiltration and improving professional satisfaction. AE were reported in 6.02% of the procedures, the most frequent being nausea and vomiting (3.88%) and transient hypoxemia (2.07%). There were no severe AE. No association was found between the incidence of AE and the clinical and functional variables or risk before anaesthesia. Conclusion: Sevoflurane sedation shows promising results in terms of safety and effectiveness for the management of agitation and pain during BoNT-A infiltration in our daily clinical practice. In addition, it can facilitate infiltration, allowing examination under sedation and multilevel infiltration with good tolerance

Pre-multisymplectic constraint algorithm for field theories

We present a geometric algorithm for obtaining consistent solutions to systems of partial differential equations, mainly arising from singular covariant first-order classical field theories. This algorithm gives an intrinsic description of all the constraint submanifolds. The field equations are stated geometrically, either representing their solutions by integrable connections or, what is equivalent, by certain kinds of integrable m-vector fields. First, we consider the problem of finding connections or multivector fields solutions to the field equations in a general framework: a pre-multisymplectic fibre bundle (which will be identified with the first-order jet bundle and the multimomentum bundle when Lagrangian and Hamiltonian field theories are considered). Then, the problem is stated and solved in a linear context, and a pointwise application of the results leads to the algorithm for the general case. In a second step, the integrability of the solutions is also studied. Finally, the method is applied to Lagrangian and Hamiltonian field theories and, for the former, the problem of finding holonomic solutions is also analized.Comment: 30 pp. Presented in the International Workshop on Geometric Methods in Modern Physics (Firenze, April 2005