165 research outputs found
RESULTS FROM A PERFORMANCE EVALUATION OF HANDWRITTEN ADDRESS RECOGNITION SYSTEMS FOR THE UNITED STATES POSTAL SERVICE
Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy
Purpose
To evaluate the reproducibility of indices of lung microstructure and function derived from 129Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level.
Methods
Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, five COPD patients were scanned on three separate days, and nine age-matched volunteers were scanned three times on one day, to assess reproducibility.
Results
CSSR-derived alveolar septal thickness (ST) and surface-area-to-volume (S/V) ratio values decreased with lung inflation level (P < 0.001; P = 0.057, respectively). Intra-subject standard deviations of ST were lower than the previously measured differences between volunteers and subjects with interstitial lung disease. The mean coefficient of variation (CV) values of ST were 3.9 ± 1.9% and 6.0 ± 4.5% in volunteers and COPD patients, respectively, similar to CV values for whole-lung carbon monoxide diffusing capacity. The mean CV of S/V in volunteers and patients was 14.1 ± 8.0% and 18.0 ± 19.3%, respectively.
Conclusion
129Xe CSSR presents a reproducible method for estimation of alveolar septal thickness
Foreground removal from CMB temperature maps using an MLP neural network
One of the main obstacles in extracting the Cosmic Microwave Background (CMB)
signal from observations in the mm-submm range is the foreground contamination
by emission from galactic components: mainly synchrotron, free-free and thermal
dust emission. Due to the statistical nature of the intrinsic CMB signal it is
essential to minimize the systematic errors in the CMB temperature
determinations. Following the available knowledge of the spectral behavior of
the galactic foregrounds simple, power law-like spectra have been assumed. The
feasibility of using a simple neural network for extracting the CMB temperature
signal from the combined CMB and foreground signals has been investigated. As a
specific example, we have analysed simulated data, like that expected from the
ESA Planck Surveyor mission. A simple multilayer perceptron neural network with
2 hidden layers can provide temperature estimates, over more than 80 percent of
the sky, that are to a high degree uncorrelated with the foreground signals. A
single network will be able to cover the dynamic range of the Planck noise
level over the entire sky.Comment: Accepted for publication in Astrophysics and Space Scienc
First Results from the DRIFT-IIa Dark Matter Detector
Data from the DRIFT-IIa directional dark matter experiment are presented,
collected during a near continuous 6 month running period. A detailed
calibration analysis comparing data from gamma-ray, x-ray and neutron sources
to a GEANT4 Monte Carlo simulations reveals an efficiency for detection of
neutron induced recoils of 94+/-2(stat.)+/-5(sys.)%. Software-based cuts,
designed to remove non-nuclear recoil events, are shown to reject 60Co
gamma-rays with a rejection factor of better than 8x10-6 for all energies above
threshold. An unexpected event population has been discovered and is shown here
to be due to the alpha-decay of 222Rn daughter nuclei that have attached to the
central cathode. A limit on the flux of neutrons in the Boulby Underground
Laboratory is derived from analysis of unshielded and shielded data.Comment: 43 pages, 14 figures, submitted to Astroparticle Physic
Protecting habitats in low-intensity tropical farmland using carbon-based payments for ecosystem services
Tropical land-use change for agricultural expansion is the primary driver of global biodiversity decline. Efforts to stem this decline often focus on protecting pristine habitats or returning farmland to forest, yet such approaches fail to protect vulnerable taxa reliant on habitats within low-intensity farmland. We assess the economic viability of carbon-based payments for ecosystem services (PES) to protect farmland trees and fallowing in Ghana, which provide vital wintering sites for imperiled Afro-palearctic migrant birds and enhance landscape-level carbon storage. We estimate the carbon breakeven prices (BEPs) associated with alternative agricultural management scenarios that protect existing farmland trees. BEPs associated with tree protection on existing farmland were very low, ranging from US6.45 t−1 CO2. Extending and reintroducing fallow periods also carried competitive BEPs, US15.45 t−1 CO2, when combined with the protection of 50 trees per hectare. Accounting for leakage and economic uncertainty increased BEPs considerably, but scenarios protecting farmland trees and extending fallow periods remained below EU Emissions Trading Scheme prices. Protecting low-intensity farmland habitats and associated biodiversity is cost-effective under carbon-based PES. Implementation should be combined with efforts to close yield gaps, providing greater local food security and resilience
Comparison of 3He and129Xe MRI for evaluation of lung microstructure and ventilation at 1.5T
BACKGROUND: To support translational lung MRI research with hyperpolarized129Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from3He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of129Xe functional metrics have not been reported. PURPOSE/HYPOTHESIS: To compare hyperpolarized129Xe and3He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1.5T. STUDY TYPE: Retrospective. POPULATION: Fourteen healthy nonsmokers (HN), five exsmokers (ES), five patients with chronic obstructive pulmonary disease (COPD), and 16 patients with nonsmall-cell lung cancer (NSCLC). FIELD STRENGTH/SEQUENCE: 1.5T. NSCLC, COPD patients and selected HN subjects underwent 3D balanced steady-state free-precession lung ventilation MRI using both3He and129Xe. Selected HN, all ES, and COPD patients underwent 2D multislice spoiled gradient-echo diffusion-weighted lung MRI using both hyperpolarized gas nuclei. ASSESSMENT: Ventilated volume percentages (VV%) and mean apparent diffusion coefficients (ADC) were derived from imaging. COPD patients performed the whole MR protocol in four separate scan sessions to assess repeatability. Same-day pulmonary function tests were performed. STATISTICAL TESTS: Intermetric correlations: Spearman's coefficient. Intergroup/internuclei differences: analysis of variance / Wilcoxon's signed rank. Repeatability: coefficient of variation (CV), intraclass correlation (ICC) coefficient. RESULTS: A significant positive correlation between3He and129Xe VV% was observed (r = 0.860, P < 0.001). VV% was larger for3He than129Xe (P = 0.001); average bias, 8.79%. A strong correlation between mean3He and129Xe ADC was obtained (r = 0.922, P < 0.001). MR parameters exhibited good correlations with pulmonary function tests. In COPD patients, mean CV of3He and129Xe VV% was 4.08% and 13.01%, respectively, with ICC coefficients of 0.541 (P = 0.061) and 0.458 (P = 0.095). Mean3He and129Xe ADC values were highly repeatable (mean CV: 2.98%, 2.77%, respectively; ICC: 0.995, P < 0.001; 0.936, P < 0.001). DATA CONCLUSION:129Xe lung MRI provides near-equivalent information to3He for quantitative lung ventilation and microstructural MRI at 1.5T. LEVEL OF EVIDENCE: 3 Technical Efficacy Stage
Track Reconstruction and Performance of DRIFT Directional Dark Matter Detectors using Alpha Particles
First results are presented from an analysis of data from the DRIFT-IIa and
DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha
particle tracks were reconstructed and used to characterise detector
performance--an important step towards optimising directional technology. The
drift velocity in DRIFT-IIa was [59.3 +/- 0.2 (stat) +/- 7.5 (sys)] m/s based
on an analysis of naturally-occurring alpha-emitting background. The drift
velocity in DRIFT-IIb was [57 +/- 1 (stat) +/- 3 (sys)] m/s determined by the
analysis of alpha particle tracks from a Po-210 source. 3D range reconstruction
and energy spectra were used to identify alpha particles from the decay of
Rn-222, Po-218, Rn-220 and Po-216. This study found that (22 +/- 2)% of Po-218
progeny (from Rn-222 decay) are produced with no net charge in 40 Torr CS2. For
Po-216 progeny (from Rn-220 decay) the uncharged fraction is (100 +0 -35)%.Comment: 27 pages, 12 figures, 5 tables. Submitted to Nuclear Instruments and
Methods in Physics Research, Section A. Subj-class: Instrumentation and
Detector
X-ray Spectroscopy and Variability of AGN Detected in the 2 Ms Chandra Deep Field-North Survey
We investigate the nature of the faint X-ray source population through X-ray
spectroscopy and variability analyses of 136 AGN detected in the 2 Ms Chandra
Deep Field-North survey with > 200 background-subtracted 0.5-8.0 keV counts
[F(0.5-8.0 keV)=(1.4-200)e-15 erg cm^{-2} s^{-1}]. Our preliminary spectral
analyses yield median spectral parameters of Gamma=1.61 and intrinsic
N_H=6.2e21 cm^{-2} (z=1 assumed when no redshift available) when the AGN
spectra are fitted with a simple absorbed power-law model. However,
considerable spectral complexity is apparent (e.g., reflection, partial
covering) and must be taken into account to model the data accurately.
Moreover, the choice of spectral model (i.e., free vs. fixed photon index) has
a pronounced effect on the derived N_H distribution and, to a lesser extent,
the X-ray luminosity distribution. Ten of the 136 AGN (~7%) show significant Fe
Kalpha emission-line features with equivalent widths in the range 0.1-1.3 keV.
Two of these emission-line AGN could potentially be Compton thick (i.e., Gamma
< 1.0 and large Fe Kalpha equivalent width). Finally, we find that 81 (~60%) of
the 136 AGN show signs of variability, and that this fraction increases
significantly (~80-90%) when better photon statistics are available.Comment: Submitted to Advances in Space Research for New X-ray Results from
Clusters of Galaxies and Black Holes (Oct 2002; Houston, TX), eds. C. Done,
E.M. Puchnarewicz, M.J. Ward. Requires cospar.sty (6 pgs, 10 figs
Measurement of the Range Component Directional Signature in a DRIFT-II Detector using 252Cf Neutrons
The DRIFT collaboration utilizes low pressure gaseous detectors to search for
WIMP dark matter with directional signatures. A 252Cf neutron source was placed
on each of the principal axes of a DRIFT detector in order to test its ability
to measure directional signatures from the three components of very low energy
(~keV/amu) recoil ranges. A high trigger threshold and the event selection
procedure ensured that only sulfur recoils were analyzed. Sulfur recoils
produced in the CS2 target gas by the 252Cf source closely match those expected
from massive WIMP induced sulfur recoils. For each orientation of the source a
directional signal from the range components was observed, indicating that the
detector is directional along all 3 axes. An analysis of these results yields
an optimal orientation for DRIFT detectors when searching for a directional
signature from WIMPs. Additional energy dependent information is provided to
aid in understanding this effect.Comment: 14 pages, 1 Table, 8 Figure
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