Behavioral Economics and Developmental Science: A New Framework to Support Early Childhood Interventions

Public policies have actively responded to an emergent social and neuroscientific evidence base documenting the benefits of targeting services to children during the earliest period of their development. But problems of low utilization, inconsistent participation, and low retention continue to present themselves as challenges. Although most interventions recognize and address structural and psycho-social barriers to parent’s engagement, few take seriously the decision making roles of parents. Using insights from the behavioral sciences, we revisit assumptions about the presumed behavior of parents in a developmental context. We then describe ways in which this framework informs features of interventions that can be designed to augment the intended impacts of early development, education and care initiatives by improving parent engagement

Public knowledge about polar regions increases while concerns remain unchanged

The authors of this brief conduct the first comparative analysis of the polar questions that were part of the National Opinion Research Center\u27s 2006 and 2010 General Social Survey. Developed by scientists at the National Science Foundation\u27s Office of Polar Programs, these questions covered topics such as climate change, melting ice and rising sea levels, and species extinction. The authors report that the public\u27s knowledge about the north and south polar regions significantly improved between 2006 and 2010--before and after the International Polar Year. In addition, respondents who know more about science in general, and polar facts specifically, tend to be more concerned about polar changes. More knowledgeable respondents also tend to favor reserving the Antarctic for science, rather than opening it for commercial development

Facile Protocol for Water-Tolerant “Frustrated Lewis Pair”-Catalyzed Hydrogenation

Despite rapid advances in the field of metal-free, “frustrated Lewis pair” (FLP)-catalyzed hydrogenation, the need for strictly anhydrous reaction conditions has hampered wide-scale uptake of this methodology. Herein, we report that, despite the generally perceived moisture sensitivity of FLPs, 1,4-dioxane solutions of B(C6F5)3 actually show appreciable moisture tolerance and can catalyze hydrogenation of a range of weakly basic substrates without the need for rigorously inert conditions. In particular, reactions can be performed directly in commercially available nonanhydrous solvents without subsequent drying or use of internal desiccants

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases. Blockade of this enzyme by atorvastatin (AT) inhibits the destructive proinflammatory T helper cell (Th)1 response during experimental autoimmune encephalomyelitis and may be beneficial in the treatment of multiple sclerosis and other Th1-mediated autoimmune diseases. Here we present evidence linking specific isoprenoid intermediates of the mevalonate pathway to signaling pathways that regulate T cell autoimmunity. We demonstrate that the isoprenoid geranylgeranyl-pyrophosphate (GGPP) mediates proliferation, whereas both GGPP and its precursor, farnesyl-PP, regulate the Th1 differentiation of myelin-reactive T cells. Depletion of these isoprenoid intermediates in vivo via oral AT administration hindered these T cell responses by decreasing geranylgeranylated RhoA and farnesylated Ras at the plasma membrane. This was associated with reduced extracellular signal-regulated kinase (ERK) and p38 phosphorylation and DNA binding of their cotarget c-fos in response to T cell receptor activation. Inhibition of ERK and p38 mimicked the effects of AT and induced a Th2 cytokine shift. Thus, by connecting isoprenoid availability to regulation of Th1/Th2 fate, we have elucidated a mechanism by which AT may suppress Th1-mediated central nervous system autoimmune disease

Arctic–CHAMP: A program to study Arctic hydrology and its role in global change

The Arctic constitutes a unique and important environment that is central to the dynamics and evolution of the Earth system. The Arctic water cycle, which controls countless physical, chemical, and biotic processes, is also unique and important. These processes, in turn, regulate the climate, habitat, and natural resources that are of great importance to both native and industrial societies. Comprehensive understanding of water cycling across the Arctic and its linkage to global biogeophysical dynamics is a scientific as well as strategic policy imperative

Arctic–CHAMP: A program to study Arctic hydrology and its role in global change

The Arctic constitutes a unique and important environment that is central to the dynamics and evolution of the Earth system. The Arctic water cycle, which controls countless physical, chemical, and biotic processes, is also unique and important. These processes, in turn, regulate the climate, habitat, and natural resources that are of great importance to both native and industrial societies. Comprehensive understanding of water cycling across the Arctic and its linkage to global biogeophysical dynamics is a scientific as well as strategic policy imperative

Low angular-dispersion microwave absorption of a dual-pitch nondiffracting metal bigrating

Copyright © 2003 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters 83 (2003) and may be found at http://link.aip.org/link/?APPLAB/83/806/1The surface plasmon modes supported by a nondiffracting 90° bigrating consisting of three grooves per repeat period with one slightly shallower than the other two are characterized by studying the reflectivity from the structure as a function of the angle of incidence and the incident wavelength (11.3<λ0<16.7 mm). This structure supports two remarkably angle-independent modes plus a further, lower-energy mode which is more dispersive. Experimental reflectivity is compared with that calculated using a finite element model. In addition, to understand the character of each of the modes, the spatial form of the electromagnetic fields at the resonant frequencies are explored

Efficient Mesh Management in Firedrake Using PETSc DMPlex

The use of composable abstractions allows the application of new and established algorithms to a wide range of problems, while automatically inheriting the benefits of well-known performance optimizations. This work highlights the composition of the PETSc DMPlex domain topology abstraction with the Firedrake automated finite element system to create a PDE solving environment that combines expressiveness, flexibility, and high performance. We describe how Firedrake utilizes DMPlex to provide the indirection maps required for finite element assembly, while supporting various mesh input formats and runtime domain decomposition. In particular, we describe how DMPlex and its accompanying data structures allow the generic creation of user-defined discretizations, while utilizing data layout optimizations that improve cache coherency and ensure overlapped communication during assembly computation