Does Immigration Affect the Long-Term Educational Outcomes of Natives? Quasi-Experimental Evidence

This paper uses the mass migration wave to Israel in the 1990s to examine the impact of immigrant concentration in elementary school on the long-term academic outcomes of native students in high school. To identify the causal effect of immigrant children on their peers, we exploit random variation in the number of immigrants across grades within the same school. The results suggest that the overall presence of immigrants had essentially no effect on the quality of the high school attended by native Israelis and on dropout rates, and at most a mild negative effect on high school matriculation rates. However, when we break up the sample by parents' education and by ethnic origin, we find that disadvantaged children were more likely to have been adversely affected by a higher immigrant concentration in elementary school. Focusing on the impact of Ethiopian immigrants who are from a much lower socio-economic background, we find stronger evidence of adverse effects, especially for disadvantaged students and in classes where immigrant concentration was particularly high.

Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population

Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association study identified evidence that variants within RELN are associated with the condition. Other genes in which an association has been reported include BMP2, COL1A1, FGF2, PPP2R5B and TGFB1. However, follow up studies have often failed to replicate initial positive results. The aim of this study was to establish if an association exists between eight single nucleotide polymorphisms (SNPs) in these six previously implicated genes and otosclerosis in a British case-control cohort (n = 748). Evidence of an association between rs1800472 in TGFB1 and otosclerosis was found (p = 0.034), this association was strongest amongst non-familial cases (p = 0.011). No evidence of an association was detected with variants in COL1A1, FGF2, BMP2, and PPP2R5B. No association between variation in RELN and otosclerosis was observed in the whole cohort. However, a significant association (p = 0.0057) was detected between one RELN SNP (rs39399) and otosclerosis in familial patients. Additionally, we identify expression of one RELN transcript in 51 of 81 human stapes tested, clarifying previous conflicting data as to whether RELN is expressed in the affected tissue. Our findings strengthen the association of TGFB1 (rs1800472) with otosclerosis and support a relationship between RELN and familial otosclerosis only, which may explain previous variable replications

A simple method to assess the oxidative susceptibility of low density lipoproteins

BACKGROUND: Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical significance. The aim of the present study was to establish a method which would allow the evaluation of oxidative susceptibility of LDL in the general clinical laboratory. RESULTS: LDL was isolated from human plasma by selective precipitation with amphipathic polymers. The ability of LDL to form peroxides was assessed by measuring thiobarbituric acid reactive substances (TBARS) after incubation with Cu(2+) and H(2)O(2). Reaction kinetics showed a three-phase pattern (latency, propagation and decomposition phases) which allowed us to select 150 min as the time point to stop the incubation by cooling and EDTA addition. The mixture Cu(2+)/H(2)O(2) yielded more lipoperoxides than each one on its own at the same time end-point. Induced peroxidation was measured in normal subjects and in type 2 diabetic patients. In the control group, results were 21.7 ± 1.5 nmol MDA/mg LDL protein, while in the diabetic group results were significantly increased (39.0 ± 3.0 nmol MDA/mg LDL protein; p < 0.001). CONCLUSION: a simple and useful method is presented for the routine determination of LDL susceptibility to peroxidation in a clinical laboratory

Mutations and altered expression of SERPINF1 in patients with familial otosclerosis

Otosclerosis is a relatively common heterogenous condition, characterized by abnormal bone remodelling in the otic capsule leading to fixation of the stapedial footplate and an associated conductive hearing loss. Although familial linkage and candidate gene association studies have been performed in recent years, little progress has been made in identifying disease-causing genes. Here, we used whole-exome sequencing in four families exhibiting dominantly inherited otosclerosis to identify 23 candidate variants (reduced to 9 after segregation analysis) for further investigation in a secondary cohort of 84 familial cases. Multiple mutations were found in the SERPINF1 (Serpin Peptidase Inhibitor, Clade F) gene which encodes PEDF (pigment epithelium-derived factor), a potent inhibitor of angiogenesis and known regulator of bone density. Six rare heterozygous SERPINF1 variants were found in seven patients in our familial otosclerosis cohort; three are missense mutations predicted to be deleterious to protein function. The other three variants are all located in the 5'-untranslated region (UTR) of an alternative spliced transcript SERPINF1-012 RNA-seq analysis demonstrated that this is the major SERPINF1 transcript in human stapes bone. Analysis of stapes from two patients with the 5'-UTR mutations showed that they had reduced expression of SERPINF1-012 All three 5'-UTR mutations are predicted to occur within transcription factor binding sites and reporter gene assays confirmed that they affect gene expression levels. Furthermore, RT-qPCR analysis of stapes bone cDNA showed that SERPINF1-012 expression is reduced in otosclerosis patients with and without SERPINF1 mutations, suggesting that it may be a common pathogenic pathway in the disease

From START to FINISH : the influence of osmotic stress on the cell cycle

Peer reviewedPublisher PD

Paradoxical effects of Worrisome Thoughts Suppression: the influence of depressive mood

Thought suppression increases the persistence of unwanted idiosyncratic worries thoughts when individuals try to suppress them. The failure of suppression may contribute to the development and maintenance of emotional disorders. Depressive people seem particulary prone to engage in unsuccessful mental control strategies such as thought suppression. Worry has been reported to be elevated in depressed individuals and a dysphoric mood may also contribute for the failure of suppression. No studies examine, however, the suppression of worisome thoughts in individuals with depressive symptoms. To investigate the suppression effects of worrisome thoughts, 46 participants were selected according to the cut-off score of a depressive symptomatology scale and they were divided in two groups (subclinical and nonclinical group). All the individuals took part in an experimental paradigm of thought suppression. The results of the mixed factorial analysis of variance revealed an increased frequency of worrisome thoughts during the suppression phase on depending of the depressive symptoms. These findings confirm that depressive mood can reduce the success of suppression.info:eu-repo/semantics/publishedVersio

A strategic integrated healthcare facility management model

The requirement to reduce expenditure on “non‐core” activities, along with building's owners’ expectations for improved performance, are the main dilemmas with which a facility manager deals on a regular basis. The primary objective of this research was to identify the effect of defined parameters, such as the actual age of a building and its level of occupancy, on the performance of facilities and their systems. This study contributed to the development of a model capable of integrating these parameters into a Facility Management (FM) tactical and strategic decision‐making process, referred to as the Integrated Healthcare Facility Management Model (IHFMM). The model's guidelines may be outlined for the methodological design and operation of facilities from a life cycle perspective. The paper presents the architecture of the developed model, and four of the 15 procedures that comprise the heart of this model. Strateginis integruotas sveikatos priežiūros pastatų ūkio valdymo modelis Santrauka Reikalavimas&nbsp;mažinti&nbsp;„neesmines“ veiklos&nbsp;išlaidas&nbsp;bei pastato&nbsp;savininkų&nbsp;lūkesčiai&nbsp;dėl&nbsp;geresnių&nbsp;rezultatų&nbsp;– su tokiomis&nbsp;pagrindinėmis&nbsp;dilemomis reguliariai susiduriapastatų&nbsp;ūkio&nbsp;valdymo vadybininkas.&nbsp;Šio&nbsp;tiriamojo darbo pagrindinis&nbsp;uždavinys&nbsp;yra nustatyti, koks yra&nbsp;apibrėžtaparametrų,&nbsp;tokių&nbsp;kaip realus pastato&nbsp;amžius&nbsp;ir jo&nbsp;užimtumolygis, poveikis&nbsp;pastatų&nbsp;ir&nbsp;jų&nbsp;sistemų&nbsp;rezultatyvumui.&nbsp;Šistyrimas&nbsp;prisidėjo&nbsp;kuriant&nbsp;modelį, kuris&nbsp;leidžia&nbsp;šiuosparametrus integruoti&nbsp;į&nbsp;taktinių&nbsp;ir&nbsp;strateginių&nbsp;pastatų&nbsp;ūkiovaldymo&nbsp;sprendimų&nbsp;priėmimo&nbsp;procesą&nbsp;ir yra vadinamas integruotu sveikatos&nbsp;priežiūros&nbsp;pastatų&nbsp;ūkio&nbsp;valdymo modeliu. Modelio rekomendacijas galima taikyti vykdantmetodologinį&nbsp;pastatų&nbsp;projektavimą&nbsp;ir&nbsp;eksploatavimą&nbsp;išgyvavimo ciklo perspektyvos.&nbsp;Šiame&nbsp;darbe pristatoma sukurto modelio&nbsp;architektūra&nbsp;ir keturios&nbsp;iš&nbsp;penkiolikos procedūrų,&nbsp;sudarančių šio&nbsp;modelio šerdį. First published online:&nbsp;18 Oct 201

The UfM and the Middle East 'Peace Process': An Unhappy Symbiosis

This contribution explores differing theories on how the failure of the ‘peace process’ featured in the design and goals of the UfM, drawing on lessons from the period when the EMP was pursued in parallel with the peace process. In each case, institutional overlaps are identified, as well as commonalities in the approaches of the actors to both pursuits. Crucially, however, the persistence and intensification of the Arab–Israeli conflict, in combination with the shift from multilateralism to bilateralism embodied in the UfM, has politicized the latter at the expense of the functionalist aspirations of its architects

Are Primary Trauma Care (PTC) courses beneficial in low- and middle-income countries - A systematic review

Background: Injuries remain an important public health concern, resulting in considerable annual morbidity and mortality. In low- and middle-income countries (LMICs), the lack of appropriate infrastructure, equipment and skilled personnel compound the burden of injury, leading to higher mortality rates. As Advanced Trauma Life Support (ATLS) courses remain uneconomical and inappropriate in LMICs, the Primary Trauma Care (PTC) course was introduced to provide an alternative that is both sustainable and appropriate to local resources. Methods: A systematic review was performed in May 2019, utilising MEDLINE, EMBASE, Cochrane Library and Google Scholar. All studies reporting patient related outcomes (mortality and morbidity rates) and course participant related outcomes (knowledge, confidence and skills) in LMICs were included. PRISMA guidelines were adhered to throughout. Results: Nine observational studies were identified (Level 3 evidence). Six studies reported improved knowledge in injury management post-PTC course ( p < 0.05). Two studies reported improvements in confidence ( p < 0.05) and one on skill attainment ( p < 0.0001). One study reported a reduction in mortality rates post-PTC course ( p < 0.01). Conclusion: Departmental, institutional and personal improvements may occur in clinical practice as a result of formal PTC training of trauma team members in LMICs. Further high-quality research is needed to evaluate this course's effects on observed change in clinical practice and patient outcomes. This may require long-term observational and epidemiological studies to assess improvements in morbidity and mortality. PROSPERO Registration Number: CRD4201913398