Hot Exoplanet Atmospheres Resolved with Transit Spectroscopy (HEARTS) I. Detection of hot neutral sodium at high altitudes on WASP-49b

High-resolution optical spectroscopy during the transit of HD 189733b, a prototypical hot Jupiter, allowed the resolution of the Na I D sodium lines in the planet, giving access to the extreme conditions of the planet upper atmosphere. We have undertaken HEARTS, a spectroscopic survey of exoplanet upper atmospheres, to perform a comparative study of hot gas giants and determine how stellar irradiation affect them. Here, we report on the first HEARTS observations of the hot Saturn-mass planet WASP-49b. We observed the planet with the HARPS high-resolution spectrograph at ESO 3.6m telescope. We collected 126 spectra of WASP-49, covering three transits of WASP-49b. We analyzed and modeled the planet transit spectrum, while paying particular attention to the treatment of potentially spurious signals of stellar origin. We spectrally resolve the Na I D lines in the planet atmosphere and show that these signatures are unlikely to arise from stellar contamination. The large contrasts of $2.0\pm0.5\%$ (D$_2$) and $1.8\pm0.7\%$ (D$_1$) require the presence of hot neutral sodium ($2,950^{+400}_{-500}$ K) at high altitudes ($\sim$1.5 planet radius or $\sim$45,000 km). From estimating the cloudiness index of WASP-49b, we determine its atmosphere to be cloud free at the altitudes probed by the sodium lines. WASP-49b is close to the border of the evaporation desert and exhibits an enhanced thermospheric signature with respect to a farther-away planet such as HD 189733b.Comment: Accepted for publication in A&A. 14 page

Co-Management of COVID-19 and heart failure during the COVID-19 pandemic. lessons learned

The COVID pandemic has brought many new challenges worldwide, which has impacted on patients with chronic conditions. There is an increasing evidence base suggesting an interaction between chronic heart failure (HF) and COVID-19, and in turn the prognostic impact of co-existence of the two conditions. Patients with existing HF appear more prone to develop severe complications on contracting COVID-19, but the exact prevalence in patients with mild symptoms of COVID-19 not requiring hospital admission is poorly investigated. In addition, hospitalization rates for acute HF over the pandemic period appear reduced compared to previous periods. Several key issues remain rather unaddressed and, importantly, a specific algorithm focused on diagnostic differentiation between HF and acute respiratory distress syndrome, a severe complication of COVID-19, is still lacking. Furthermore, recent data suggests potential interaction existing between HF treatment and some anti-viral anti-inflammatory drugs prescribed during the infection, raising some doubts about a universal treatment strategy for all patients with COVID-19. With this manuscript, we aim to review the current literature in this field in light of growing understanding of COVID-19 in the setting of the HF population, its associated morbidity and mortality burden, and the impact on healthcare systems. We hope that this may stimulate a discussion to guarantee a better, more tailored delivery of care for patients with HF in the setting of concomitant COVID-19 infection

Correlation Differences in Heartbeat Fluctuations During Rest and Exercise

We study the heartbeat activity of healthy individuals at rest and during exercise. We focus on correlation properties of the intervals formed by successive peaks in the pulse wave and find significant scaling differences between rest and exercise. For exercise the interval series is anticorrelated at short time scales and correlated at intermediate time scales, while for rest we observe the opposite crossover pattern -- from strong correlations in the short-time regime to weaker correlations at larger scales. We suggest a physiologically motivated stochastic scenario to explain the scaling differences between rest and exercise and the observed crossover patterns.Comment: 4 pages, 4 figure

A spectral survey of an ultra-hot Jupiter: Detection of metals in the transmission spectrum of KELT-9 b

Context: KELT-9 b exemplifies a newly emerging class of short-period gaseous exoplanets that tend to orbit hot, early type stars - termed ultra-hot Jupiters. The severe stellar irradiation heats their atmospheres to temperatures of $\sim 4,000$ K, similar to the photospheres of dwarf stars. Due to the absence of aerosols and complex molecular chemistry at such temperatures, these planets offer the potential of detailed chemical characterisation through transit and day-side spectroscopy. Studies of their chemical inventories may provide crucial constraints on their formation process and evolution history. Aims: To search the optical transmission spectrum of KELT-9 b for absorption lines by metals using the cross-correlation technique. Methods: We analyse 2 transits observed with the HARPS-N spectrograph. We use an isothermal equilibrium chemistry model to predict the transmission spectrum for each of the neutral and singly-ionized atoms with atomic numbers between 3 and 78. Of these, we identify the elements that are expected to have spectral lines in the visible wavelength range and use those as cross-correlation templates. Results: We detect absorption of Na I, Cr II, Sc II and Y II, and confirm previous detections of Mg I, Fe I, Fe II and Ti II. In addition, we find evidence of Ca I, Cr I, Co I, and Sr II that will require further observations to verify. The detected absorption lines are significantly deeper than model predictions, suggesting that material is transported to higher altitudes where the density is enhanced compared to a hydrostatic profile. There appears to be no significant blue-shift of the absorption spectrum due to a net day-to-night side wind. In particular, the strong Fe II feature is shifted by $0.18 \pm 0.27$ km~s$^{-1}$, consistent with zero. Using the orbital velocity of the planet we revise the steller and planetary masses and radii.Comment: Submitted to Astronomy and Astrophysics on January 18, 2019. Accepted on May 3, 2019. 26 pages, 11 figure

Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome.

OBJECTIVE: To determine the association of resistance exercise, independent of and combined with aerobic exercise, with the risk of development of metabolic syndrome (MetS). PATIENTS AND METHODS: The study cohort included adults (mean ± SD age, 46±9.5 years) who received comprehensive medical examinations at the Cooper Clinic in Dallas, Texas, between January 1, 1987, and December, 31, 2006. Exercise was assessed by self-reported frequency and minutes per week of resistance and aerobic exercise and meeting the US Physical Activity Guidelines (resistance exercise ≥2 d/wk; aerobic exercise ≥500 metabolic equivalent min/wk) at baseline. The incidence of MetS was based on the National Cholesterol Education Program Adult Treatment Panel III criteria. We used Cox regression to generate hazard ratios (HRs) and 95% CIs. RESULTS: Among 7418 participants, 1147 (15%) had development of MetS during a median follow-up of 4 years (maximum, 19 years; minimum, 0.1 year). Meeting the resistance exercise guidelines was associated with a 17% lower risk of MetS (HR, 0.83; 95% CI, 0.73-0.96; P=.009) after adjusting for potential confounders and aerobic exercise. Further, less than 1 hour of weekly resistance exercise was associated with 29% lower risk of development of MetS (HR, 0.71; 95% CI, 0.56-0.89; P=.003) compared with no resistance exercise. However, larger amounts of resistance exercise did not provide further benefits. Individuals meeting both recommended resistance and aerobic exercise guidelines had a 25% lower risk of development of MetS (HR, 0.75; 95% CI, 0.63-0.89; P<.001) compared with meeting neither guideline. CONCLUSION: Participating in resistance exercise, even less than 1 hour per week, was associated with a lower risk of development of MetS, independent of aerobic exercise. Health professionals should recommend that patients perform resistance exercise along with aerobic exercise to reduce MetS