Towards a Broader View of Hunter-Gatherer Sharing

This book was funded by the EU 7th Framework Programme (7FP), TropicMicroArch 623293 Project (http://cordis.europa.eu/project/rcn/187754_en.html). The book will be Open Access, thanks to FP7 post-grant Open Access (https://www.openaire.eu/postgrantoapilot)

Site Formation Processes and Hunter-Gatherers Use of Space in a Tropical Environment: A Geo-Ethnoarchaeological Approach from South India.

Hunter-gatherer societies have distinct social perceptions and practices which are expressed in unique use of space and material deposition patterns. However, the identification of archaeological evidence associated with hunter-gatherer activity is often challenging, especially in tropical environments such as rainforests. We present an integrated study combining ethnoarchaeology and geoarchaeology in order to study archaeological site formation processes related to hunter-gatherers' ways of living in tropical forests. Ethnographic data was collected from an habitation site of contemporary hunter-gatherers in the forests of South India, aimed at studying how everyday activities and way of living dictate patterns of material deposition. Ethnoarchaeological excavations of abandoned open-air sites and a rock-shelter of the same group located deep in the forests, involved field observations and sampling of sediments from the abandoned sites and the contemporary site. Laboratory analyses included geochemical analysis (i.e., FTIR, ICP-AES), phytolith concentration analysis and soil micromorphology. The results present a dynamic spatial deposition pattern of macroscopic, microscopic and chemical materials, which stem from the distinctive ways of living and use of space by hunter-gatherers. This study shows that post-depositional processes in tropical forests result in poor preservation of archaeological materials due to acidic conditions and intensive biological activity within the sediments. Yet, the multiple laboratory-based analyses were able to trace evidence for activity surfaces and their maintenance practices as well as localized concentrations of activity remains such as the use of plants, metals, hearths and construction materials.The research leading to these results has received funding form the People Programme (Marie Curie Actions—http://ec.europa.eu/research/mariecurieactions/) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA agreement n° 623293 granted to DF at the McDonald Institute for Archaeological Research, University of Cambridge. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This is the final version of the article. It first appeared from PLOS via https://doi.org/10.1371/journal.pone.016418

Daratumumab With Cetrelimab, an Anti-PD-1 Monoclonal Antibody, in Relapsed/Refractory Multiple Myeloma

Patients with relapsed or refractory multiple myeloma have an immunosuppressive state with upregulation of programmed death receptor-1 on immune effector cells. Treatment with daratumumab plus cetrelimab, which targets the programmed death receptor-1, was evaluated in 9 patients with relapsed or refractory multiple myeloma. No new safety concerns were identified for the combination. The potential clinical benefit of daratumumab plus cetrelimab remains uncertain. Background: Daratumumab is approved for relapsed or refractory multiple myeloma (RRMM) as monotherapy or in combination regimens. We evaluated daratumumab plus cetrelimab, a programmed death receptor-1 inhibitor, in RRMM. Patients and Methods: This open-label, multiphase study enrolled adults with RRMM with >= 3 prior lines of therapy. Part 1 was a safety run-in phase examining dose-limiting toxicities of daratumumab (16 mg/kg intravenously weekly for cycles 1-2, biweekly for cycles 3-6, and monthly thereafter) plus cetrelimab (240 mg intravenously biweekly, all cycles). In Parts 2 and 3, patients were to be randomized to daratumumab with or without cetrelimab (same schedule as Part 1). Endpoints included safety, overall response rate, pharmacokinetics, and biomarker analyses. Results: Nine patients received daratumumab plus cetrelimab in the safety run-in, and 1 received daratumumab in Part 2 before administrative study termination following a data monitoring committee's global recommendation to stop any trial including daratumumab combined with inhibitors of programmed death receptor-1 or its ligand (programmed death-ligand 1). The median follow-up times were 6.7 months (safety run-in) and 0.3 months (Part 2). No dose-limiting toxicities occurred. All 10 patients had >= 1 treatment-emergent adverse event; 7 patients had grade 3 to 4 treatment-emergent adverse events, and none led to treatment discontinuation or death. In the safety run-in, 7 (77.7%) patients had > 1 infusion-related reaction (most grade 1-2), and 1 had a grade 2 immune-mediated reaction. Among safety run-in patients, the overall response rate was 44.4%. Conclusions: No new safety concerns were identified for daratumumab plus cetrelimab in RRMM. The short study duration and small population limit complete analysis of this combination. (C) 2020 The Author(s). Published by Elsevier Inc

Introduction

This book was funded by the EU 7th Framework Programme (7FP), TropicMicroArch 623293 Project (http://cordis.europa.eu/project/rcn/187754_en.html). The book will be Open Access, thanks to FP7 post-grant Open Access (https://www.openaire.eu/postgrantoapilot)

An ethnoarchaeological view on hunter-gatherer sharing and its archaeological implications for the use of social space

This book was funded by the EU 7th Framework Programme (7FP), TropicMicroArch 623293 Project (http://cordis.europa.eu/project/rcn/187754_en.html). The book will be Open Access, thanks to FP7 post-grant Open Access (https://www.openaire.eu/postgrantoapilot)

Rewild Your Inner Hunter-Gatherer: How an Idea about Our Ancestral Condition Is Recruited into Popular Debate in Britain and Ireland

We examine how hunter-gatherers are imagined in popular debate in Britain and Ireland, demonstrating that aspects of hunter-gatherer lifestyles are presented as both the antithesis and antidote to perceived crises in contemporary society. We apply an anthropological lens to four areas of popular discourse: physical health, mental health, bush-craft and survivalism. We identify how the imagined hunter-gatherer in these debates is constructed through processes of commodification, which often reveal nostalgic colonial values regarding ‘human nature’. This repeats and sustains damaging perceptions of hunter-gatherer lifeways. It also highlights how archaeological, anthropological and other academic research on hunter-gatherers is manifest in popular debates that reinforce assumptions about human nature and the significance of our evolutionary past within a neoliberal, colonialist context

Rewild your inner hunter-gatherer: how an idea about our ancestral condition is recruited into popular debate in Britain and Ireland

We examine how hunter-gatherers are imagined in popular debate in Britain and Ireland, demonstrating that aspects of hunter-gatherer lifestyles are presented as both the antithesis and antidote to perceived crises in contemporary society. We apply an anthropological lens to four areas of popular discourse: physical health, mental health, bush-craft and survivalism. We identify how the imagined hunter-gatherer in these debates is constructed through processes of commodification, which often reveal nostalgic colonial values regarding ‘human nature’. This repeats and sustains damaging perceptions of hunter-gatherer lifeways. It also highlights how archaeological, anthropological and other academic research on hunter-gatherers is manifest in popular debates that reinforce assumptions about human nature and the significance of our evolutionary past within a neoliberal, colonialist context.2022-04-11 JG: update citation details, pub date, DOI, copyright year on check dat