633 research outputs found
Towards More Practical Linear Programming-based Techniques for Algorithmic Mechanism Design
R. Lavy and C. Swamy (FOCS 2005, J. ACM 2011) introduced a general method for
obtaining truthful-in-expectation mechanisms from linear programming based
approximation algorithms. Due to the use of the Ellipsoid method, a direct
implementation of the method is unlikely to be efficient in practice. We
propose to use the much simpler and usually faster multiplicative weights
update method instead. The simplification comes at the cost of slightly weaker
approximation and truthfulness guarantees
Budget Feasible Mechanisms for Experimental Design
In the classical experimental design setting, an experimenter E has access to
a population of potential experiment subjects , each
associated with a vector of features . Conducting an experiment
with subject reveals an unknown value to E. E typically assumes
some hypothetical relationship between 's and 's, e.g., , and estimates from experiments, e.g., through linear
regression. As a proxy for various practical constraints, E may select only a
subset of subjects on which to conduct the experiment.
We initiate the study of budgeted mechanisms for experimental design. In this
setting, E has a budget . Each subject declares an associated cost to be part of the experiment, and must be paid at least her cost. In
particular, the Experimental Design Problem (EDP) is to find a set of
subjects for the experiment that maximizes V(S) = \log\det(I_d+\sum_{i\in
S}x_i\T{x_i}) under the constraint ; our objective
function corresponds to the information gain in parameter that is
learned through linear regression methods, and is related to the so-called
-optimality criterion. Further, the subjects are strategic and may lie about
their costs.
We present a deterministic, polynomial time, budget feasible mechanism
scheme, that is approximately truthful and yields a constant factor
approximation to EDP. In particular, for any small and , we can construct a (12.98, )-approximate mechanism that is
-truthful and runs in polynomial time in both and
. We also establish that no truthful,
budget-feasible algorithms is possible within a factor 2 approximation, and
show how to generalize our approach to a wide class of learning problems,
beyond linear regression
Full-scale ground proximity investigation of a VTOL fighter model aircraft
Exhaust gas ingestion characteristics and induced aerodynamics for vertical takeoff lift engine fighter model in ground proximit
A model for the domestication of Panicum miliaceum (common, proso or broomcorn millet) in China
This paper outlines a model for the domestication of Panicum miliaceum (broomcorn millet) in Northern China. Data from 43 archaeological sites indicate a continuous increase in average grain size between 6000 and 3300 BC. After this date there is a divergence, with grain size continuing to increase in some populations, while others show no further size increase. The initial increase in grain size is attributed to selection during domestication, while later divergence after 3300 BC is interpreted as resulting from post-domestication selection. Measurements of grains from two archaeological populations of P. ruderale, showed grains were longer in length by 3300 BC than the earliest grains of P. miliaceum. This suggests this sub-species includes many feral, weedy and/or introgressed forms of P. miliaceum and therefore is probably not entirely representative of the true wild ancestor. It is argued that changes from shattering to non-shattering are contemporary with increasing grain size and the commencement of cultivation. The window of P. miliaceum domestication is therefore likely to lie between 7000 and 3300 BC. However, it is probable that a lengthy period of millet harvesting and small-scale management preceded its domestication
Bribeproof mechanisms for two-values domains
Schummer (Journal of Economic Theory 2000) introduced the concept of
bribeproof mechanism which, in a context where monetary transfer between agents
is possible, requires that manipulations through bribes are ruled out.
Unfortunately, in many domains, the only bribeproof mechanisms are the trivial
ones which return a fixed outcome.
This work presents one of the few constructions of non-trivial bribeproof
mechanisms for these quasi-linear environments. Though the suggested
construction applies to rather restricted domains, the results obtained are
tight: For several natural problems, the method yields the only possible
bribeproof mechanism and no such mechanism is possible on more general domains.Comment: Extended abstract accepted to SAGT 2016. This ArXiv version corrects
typos in the proofs of Theorem 7 and Claims 28-29 of prior ArXiv versio
Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model
Practically, all chemotherapeutic agents lead to drug resistance. Clinically,
it is a challenge to determine whether resistance arises prior to, or as a
result of, cancer therapy. Further, a number of different intracellular and
microenvironmental factors have been correlated with the emergence of drug
resistance. With the goal of better understanding drug resistance and its
connection with the tumor microenvironment, we have developed a hybrid
discrete-continuous mathematical model. In this model, cancer cells described
through a particle-spring approach respond to dynamically changing oxygen and
DNA damaging drug concentrations described through partial differential
equations. We thoroughly explored the behavior of our self-calibrated model
under the following common conditions: a fixed layout of the vasculature, an
identical initial configuration of cancer cells, the same mechanism of drug
action, and one mechanism of cellular response to the drug. We considered one
set of simulations in which drug resistance existed prior to the start of
treatment, and another set in which drug resistance is acquired in response to
treatment. This allows us to compare how both kinds of resistance influence the
spatial and temporal dynamics of the developing tumor, and its clonal
diversity. We show that both pre-existing and acquired resistance can give rise
to three biologically distinct parameter regimes: successful tumor eradication,
reduced effectiveness of drug during the course of treatment (resistance), and
complete treatment failure
The rising incidence of severe sepsis based on administrative data — real change or coding-driven bias?
Clustering of serotypes in a longitudinal study of Streptococcus pneumoniae carriage in three day care centres
<p>Abstract</p> <p>Background</p> <p><it>Streptococcus pneumoniae </it>(pneumococcus) causes a wide range of clinical manifestations that together constitute a major burden of disease worldwide. The main route of pneumococcal transmission is through asymptomatic colonisation of the nasopharynx. Studies of transmission are currently of general interest because of the impact of the new conjugate-polysaccharide vaccines on nasopharyngeal colonisation (carriage). Here we report the first longitudinal study of pneumococcal carriage that records serotype specific exposure to pneumococci simultaneously within the two most important mixing groups, families and day care facilities.</p> <p>Methods</p> <p>We followed attendees (N = 59) with their family members (N = 117) and the employees (N = 37) in three Finnish day care centres for 9 months with monthly sampling of nasopharyngeal carriage. Pneumococci were cultured, identified and serotyped by standard methods.</p> <p>Results</p> <p>Children in day care constitute a core group of pneumococcal carriage: of the 36 acquisitions of carriage with documented exposure to homologous pneumococci, the attendee had been exposed in her/his day care centre in 35 cases and in the family in 9 cases. Day care children introduce pneumococci to the family: 66% of acquisitions of a new serotype in a family were associated with simultaneous or previous carriage of the same type in the child attending day care. Consequently, pneumococcal transmission was found to take place as micro-epidemics driven by the day care centres. Each of the three day care centres was dominated by a serotype of its own, accounting for 100% of the isolates of that serotype among all samples from the day care attendees.</p> <p>Conclusion</p> <p>The transmission of pneumococci is more intense within than across clusters defined by day care facilities. The ensuing micro-epidemic behaviour enhances pneumococcal transmission.</p
Humane Killing and the Ethics of the Secular: Regulating the Death Penalty, Euthanasia, and Animal Slaughter
An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock
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