Maupassant et l'irrémédiable (le temps dans l'oeuvre romanesque de Guy de Maupassant)

Combinant les approches structurelle, narratologique, thématique et les perspectives philosophiques, ce travail, portant sur l'ensemble des romans de Maupassant, se présente comme une analyse des diverses formes de la temporalité romanesque, souvent délaissée au profit de l'étude de l'espace ou du registre descriptif. Ces approches complémentaires font clairement apparaître l'importance de la notion d'irrémédiable dans l'expérience maupassantienne du temps, et plus généralement dans une vision du monde caractérisée par un pessimisme tragique. La mémoire, aussi bien que l'anticipation ou la jouissance du présent, sont ainsi marquées du sceau de la destruction et de l'angoisse. A telle enseigne que ces trois "catégories" fondamentales de l'expérience se trouvent en définitive totalement bouleversées, les personnages étant tous plus ou moins aux prises avec la confusion des temps. Manière, encore et toujours, d'accentuer leur égarement dans une histoire dont ils apparaissent radicalement coupés, et qu'ils ne font plus que subir passivement. Face à cette faillite généralisée, l'écriture de Maupassant demeure remarquablement limpide, et par sa transparence même, apte à fixer le vertige du définitivement perdu.Dealing with all Maupassant's novels and combining the structural approach with the narratologic, thematic and philosophical ones, this work presents itself as an analysis of the different kinds of novelistic temporality wich are often neglected for space's and description's studies. According to these complementary approaches, it would appear that the notion of the inevitable is really important in Maupassant's experience of time, and more generally in a world's view marked with tragical pessimism. The memory as well as the anticipation or the enjoyment of the present are thus bearing the mark of destruction and fear, so much so that these three basic " categories " of experience are completly disrupted, all the characters having more or less to cope with the confusion of times. A way still to emphasize their distress in a History from wich they seem completly cut off and wich they can only passively bear. In front of this generalised failure, Maupassant's writing remains remarkably lucid and throuh this very transparency, remains able to implant in the memory the vertigo of what is definitively lost.NANTERRE-BU PARIS10 (920502102) / SudocSudocFranceF

La polychondrite chronique atrophiante et ses complications cardiovasculaires

PARIS6-Bibl. St Antoine CHU (751122104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Cardiac Metastasis from Medullary Thyroid Cancers with Long-Term Survival under Vandetanib

International audienceBackground: Cardiac metastases from thyroid cancers are uncommon with a poor prognosis. There is a lack of long-term follow-up studies. Cases: We report 2 cases of cardiac metastasis from medullary thyroid cancer (MTC). Both patients presented limited metastatic disease apart from a cardiac metastasis. The initial diagnosis was challenging and was facilitated by functional imaging with an immuno-PET-CT using an anti-CEA bispecific antibody and a 68Ga-labeled peptide. Both patients were treated with the multitarget kinase inhibitor vandetanib with prolonged stability. The first patient was alive at the last follow-up, 14 years after the diagnosis of cardiac metastasis. The second patient required surgical excision of the cardiac mass because of disease progression under vandetanib. Conclusion: These cases illustrate long-term survival and effectiveness of clinical management of 2 patients who developed cardiac metastases from MTC, in the current era of personalized medicine with targeted therapy

Étude 'Innovation et recherche dans la mode et le luxe'- Institut Carnot-CARATS avec le soutien du DÉFI

Restitution des ateliers de conception innovante organisés entre professionnels de la filière industrielle mode & luxe et scientifiques sur les enjeux contemporains du secteu

Étude 'Innovation et recherche dans la mode et le luxe'- Institut Carnot-CARATS avec le soutien du DÉFI

Restitution des ateliers de conception innovante organisés entre professionnels de la filière industrielle mode & luxe et scientifiques sur les enjeux contemporains du secteu

close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design.

RATIONALE: Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke AIM: To assess whether transcatheter patent foramen ovale closure plus antiplatelet therapy is superior to antiplatelet therapy alone and whether oral anticoagulant therapy is superior to antiplatelet therapy, for secondary stroke prevention in patients aged 16 to 60 years with a large patent foramen ovale or a patent foramen ovale associated with an atrial septal aneurysm, and an otherwise unexplained ischaemic stroke or retinal ischaemia. SAMPLE SIZE: Six hundred and sixty-four patients were included in the study. METHODS AND DESIGN: CLOSE is an academic-driven, multicentre, randomized, open-label, three-group, superiority trial with blinded adjudication of outcome events. The trial has been registered with Clinical Trials Register (Clinicaltrials.gov, NCT00562289). Patient recruitment started in December 2007. Patient follow-up will continue until December 2016. Expected mean follow-up = 5.6 years. STUDY OUTCOMES: The primary efficacy outcome is the occurrence of fatal or nonfatal stroke. Safety outcomes include fatal, life-threatening or major procedure- or device-related complications and fatal, life-threatening or major haemorrhagic complications. DISCUSSION: CLOSE is the first specifically designed trial to assess the superiority of patent foramen ovale closure over antiplatelet therapy alone and the superiority of oral anticoagulants over antiplatelet therapy to prevent stroke recurrence in patients with patent foramen ovale-associated cryptogenic stroke