478 research outputs found

    Meaningful Teacher-Student Relationships in Kentucky\u27s Career and Technical Education Programs

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    A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Vogenau College of Education at Morehead State University by Laura Mae Sommer Williams on April 14, 2021

    Contextualizing information enhances the experience of environmental art.

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    Environmentally themed art is increasingly addressed in research as a means to raise awareness of environmental problems and motivate proenvironmental behavior. However, as researchers begin to systematically study environmental art, influencing factors must be addressed—for example, the effect of presenting contextualizing information. In the present study, 123 participants saw an environmental artwork with or without contextualizing information in a between-subjects design and rated the artwork on various variables regarding its aesthetic value and proenvironmental impact. Additionally, eye movement was recorded using mobile eye-tracking glasses to gain insight into the visual processing of the artwork. The results showed that information presentation increased personal meaning, which was in turn associated with increased liking, interest, and emotional responses. The average duration of fixations was shorter for participants in the information group, indicating easier processing possibly due to the guidance of the provided information. However, information had no effects on participants’ proenvironmental intentions and behavior. Taken together, the results strongly suggest that both researchers and practitioners should be taking the effect of contextualizing information into account when exhibiting environmental art, because it can impact a variety of relevant factors

    Pollution Pods: can art change people’s perception of climate change and air pollution?

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    The artwork Pollution Pods is part of the Climart project, a wider research program that looks to explore the ways in which art can change people’s perception of climate change. Before presenting the Pollution Pods project itself, Michael Pinsky describes his process of artistic creation and explains how his work engages with the challenge of “representing the invisible”. The conception of Pollution Pods is part of a scientific work studying the type of reaction that climate art can bring about in audiences, thinking specifically about the extent to which artworks lead people not only to reflect on the reality of their daily lives, but also to alter their behaviour.With Pollution Pods, the artist hopes to disrupt our embodied experience of pollution, which is generally that of a background phenomenon to which we grow accustomed. To do this, five geodesic domes, five closed physical spaces containing toxic air from different cities around the world, are connected, forcing visitors to experience abrupt change in air quality. Pollution Pods is an eminently sensorial experience, whose objective is not so much to offer a privileged audience the thrill of danger safely contained, but rather to push visitors to reflect on their own contradictions and trigger behavioural change, as the embodied knowledge of pollution renders willful ignorance almost intolerable

    Aura versus Dialogue. Displaying Nazi Objects in the Exhibition "Disposing of Hitler: Out of the Cellar, Into the Museum"

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    What should we do with the remnants of Nazism? Should we dispose of them? Is it acceptable to sell them at a flea market or on the internet? At what point does memory become nostalgia, or even illegal neo-Nazi activity? Objects related to Nazism get discovered in various places and contexts – whether in one’s own basement, at flea markets or an online portal, in the estate of relatives or even in the trash. Even if one’s own family history is not entangled with the Nazi regime, such finds trigger feelings ranging from shame to detachment and even fascination. The exhibition "Disposing of Hitler. Out of the Cellar, Into the Museum", House of Austrian History ("Hitler entsorgen. Vom Keller ins Museum", Haus der Geschichte Österreich) asks about the social responsibility in dealing with relics of Nazism and explores the question of how these things can strengthen democratic consciousness in the present. What should we do with the remnants of Nazism? Should we dispose of them? Is it acceptable to sell them at a flea market or on the internet? At what point does memory become nostalgia, or even illegal neo-Nazi activity? Objects related to Nazism get discovered in various places and contexts – whether in one’s own basement, at flea markets or an online portal, in the estate of relatives or even in the trash. Even if one’s own family history is not entangled with the Nazi regime, such finds trigger feelings ranging from shame to detachment and even fascination. The exhibition "Disposing of Hitler. Out of the Cellar, Into the Museum", House of Austrian History ("Hitler entsorgen. Vom Keller ins Museum", Haus der Geschichte Österreich) asks about the social responsibility in dealing with relics of Nazism and explores the question of how these things can strengthen democratic consciousness in the present.&nbsp

    Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

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    Human small cell lung cancer (SCLC) is highly aggressive, and quickly develops resistance to therapy. SCLC cells are typically insensitive to glucocorticoids due to impaired glucocorticoid receptor (GR) expression. This is important as we have previously shown that expression of a GR transgene induces cell death in-vitro, and inhibits tumor growth in-vivo. However, the underlying mechanism for loss of GR expression is unknown. The SCLC cell line, DMS79, has low GR expression, compared to non-SCLC cell lines and normal bronchial epithelial cells. Retroviral GR expression in DMS79 cells caused activation of the apoptotic pathway as evidenced by marked induction of caspase-3 activity. Methylation analysis of the GR promoter revealed some methylation in the 1D, and 1E promoters of the GR gene, however the ubiquitous constitutively active 1C promoter was heavily methylated. In the 1C promoter there was a highly significant increase in DNA methylation in a panel of 14 human SCLC cell lines compared to a mixed panel of GR expressing, and non-expressing cell lines, and to peripheral blood mononuclear cells. Furthermore, within the panel of SCLC cell lines there was a significant negative correlation seen between methylation of the 1C promoter, and GR protein expression. Reversal of GR gene methylation with DNA methyltransferase inhibition caused increased GR mRNA and protein expression in SCLC but not non-SCLC cells. This resulted in increased Gc sensitivity, decreased Bcl-2 expression and increased caspase-3 activity in SCLC cells. These data suggest that DNA methylation decreases GR gene expression in human SCLC cells, in a similar manner to that for conventional tumor suppressor genes

    Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids

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    The mucin MUC1 is a glycoprotein involved in fundamental biological processes, which can be found over-expressed and with a distinctly altered glycan pattern on epithelial tumor cells; thus it is a promising target structure in the quest for effective carbohydrate-based cancer vaccines and immunotherapeutics. Natural glycopeptide antigens indicate only a low immunogenicity and a T-cell independent immune response; however, this major drawback can be overcome by coupling of glycopeptide antigens multivalently to immunostimulating carrier platforms. In particular, gold nanoparticles are well suited as templates for the multivalent presentation of glycopeptide antigens, due to their remarkably high surface-to-volume ratio in combination with their high biostability. In this work the synthesis of novel MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes are presented. In addition, the development of a new dot-blot immunoassay to test the potential antigen-antibody binding is introduced

    Aproximando las Ciencias de la Computación a la escuela secundaria

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    La enseñanza de las Ciencias de la Computación en el ámbito de la educación obligatoria ha logrado altos niveles de consenso en los últimos años. En Argentina convergen varias iniciativas promovidas por las Universidades, Program.ar y el Programa Nacional Conectar Igualdad que buscan mejorar la aproximación de las Ciencias de la Computación a la escuela secundaria. La incorporación de forma sostenible y rigurosa de la enseñanza de las Ciencias de la Computación en la educación secundaria es aún un proceso en desarrollo en la mayoría de los países. En este trabajo se presenta una Línea de Investigación que busca avanzar en la definición de modelos y enfoques metodológicos que impacten positivamente en los procesos de aproximación de las Ciencias de la Computación a la escuela secundaria. Se presta especial atención a la innovación a partir de la integración de recursos didáctico disciplinares como robótica educativa y programación tangible.Eje: Innovación en Educación en Informática.Red de Universidades con Carreras en Informática (RedUNCI

    Partial Remodeling after Conservative Treatment of Trampoline Fractures in Children

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    (1) Background: Trampoline fractures (proximal tibia fracture with positive anterior tilt) are increasing. This study represents the first attempt to determine the extent of remodeling in these fractures after conservative treatment (2) Methods: This Swiss prospective multicenter study included children aged 2 to 5 years with a trampoline fracture who were radiologically examined on the day of the accident and after one year. In addition, the anterior tilt angle was compared between the injured and unaffected tibia. Remodeling was defined as complete (final anterior tilt angle ≤ 0°), incomplete (smaller but still >0°), or no remodeling. (3) Results: The mean extent of remodeling was −3.5° (95% CI: −4.29°, −2.66°, p p 1 year after the trauma showed advanced remodeling, suggesting that one year is too short to observe complete remodeling

    Factors affecting fruit and vegetable consumption and purchase behavior of adults in sub-Saharan Africa:A rapid review

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    In order to achieve the Sustainable Development Goals, considerable dietary shifts, including an increase in the consumption of fruit and vegetables (FV) will be required. However, worldwide consumption of FV is far below international recommendations, including in many low- and middle-income countries (LMICs), particularly in Africa. Understanding what, where, when, and how people choose to eat requires an understanding of how individuals are influenced by factors in their social, physical, and macro-level environments. In order to develop effective interventions to increase fruit and vegetable consumption, the factors influencing consumer behavior need to be better understood. We conducted a rapid review to assess and synthesize data on individual, social, physical, and macro-level factors that enable or constrain fruit and vegetable consumption and purchase among adults living in sub-Saharan Africa. Our conceptual framework is based on a socio-ecological model which has been adapted to settings in LMICs and Africa. We systematically searched four electronic databases including Scopus, Medline (PubMed), PsycInfo, and African Index Medicus, and screened Google Scholar for gray literature. We included a total of 52 studies and narratively summarized the existing evidence for each identified factor across the different levels. We found that most studies assessed demographic factors at the individual level including household or family income, socio-economic status and education. Furthermore we identified a variety of important factors that influence FV consumption, in the social, physical, and macro environment. These include women's empowerment and gender inequalities, the influence of neighborhood and retail food environment such as distance to market and price of FV as well as the importance of natural landscapes including forest areas for FV consumption. This review identified the need to develop and improve indicators both for exposure and outcome variables but also to diversify research approaches
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