449 research outputs found
Design and Evaluation of Frequency Weighted LQG Maximum Entropy Controllers on an Experimental Tmss Structure
This paper will discuss the experimental evaluation of a structural control system designed using a combination of Frequency Weighted LQG and Maximum Entropy. The experimental implementation was performed on an experimental truss structure, the Sandia Truss, which is described in the paper. The control design model was obtained via experimental system identification using the eigensystem realization algorithm with data correlation. The control design used frequency weighting to stabilize the unstructured uncertainty of the system due to low signal-to-noise and uncertain system dynamics in various frequency ranges. Maximum entropy is used to provide robustness for structured uncertain system dynamics within the controller bandwidth. The experimental implementation of the controllers designed with this approach show the ability to design controllers with a specified bandwidth, gain .Uabilization of unstructured uncertainty, and robustness to structured uncertainty within the controller bandwidth
PMH62 THE SPANISH VERSION OF THE TOOL QUESTIONNAIRE: VALIDATION OF A SPECIFIC MEASURE TO EVALUATE HEALTH RELATED QUALITY OF LIFE (HRQOL) IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER
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The Vibration Virtual Environment for Test Optimization (VETO)
A new test simulation tool is being developed to support vibration test design and to evaluate the overall testability of a component or system. This environment, the Vibration Virtual Environment for Test Optimization (VETO), is utilized to optimally place vibration control and response transducers and to investigate the selection of test parameters needed in the design and performance of a vibration experiment. The engineer can investigate the effects of different control parameters prior to performing an actual vibration test. Additionally, new and existing fixture designs can be evaluated through the development of analytical or experimental models that can be integrated into the simulation environment. This test design environment also provides the engineer with the ability to combine analytically or experimentally derived models of the vibration test hardware, instrumentation and equipment into a simulation model that represents the vibration testing capability. Hardware-in-the-loop simulations can be conducted using this model to examine multiple facets of the test design. This paper presents a new tool that will assist test engineers in maximizing the value of vibration tests through the use of hardware-in-the-loop simulations
Mapping of functionalized regions on carbon nanotubes by scanning tunneling microscopy
Scanning tunneling microscopy (STM) gives us the opportunity to map the
surface of functionalized carbon nanotubes in an energy resolved manner and
with atomic precision. But this potential is largely untapped, mainly due to
sample stability issues which inhibit reliable measurements. Here we present a
simple and straightforward solution that makes away with this difficulty, by
incorporating the functionalized multiwalled carbon nanotubes (MWCNT) into a
few layer graphene - nanotube composite. This enabled us to measure energy
resolved tunneling conductance maps on the nanotubes, which shed light on the
level of doping, charge transfer between tube and functional groups and the
dependence of defect creation or functionalization on crystallographic
orientation.Comment: Keywords: functionalization, carbon nanotubes, few layer graphene,
STM, CITS, ST
MRI sensing based on the displacement of paramagnetic ions from chelated complexes
We introduce a mechanism for ion sensing by MRI in which analytes compete with paramagnetic ions for binding to polydentate chelating agents. Displacement of the paramagnetic ions results in alteration of solvent interaction parameters and consequent changes in relaxivity and MRI contrast. The MRI changes can be tuned by the choice of chelator. As an example, we show that calcium-dependent displacement of Mn[superscript 2+] ions bound to EGTA and BAPTA results in a T[subscript 1]-weighted MRI signal increase, whereas displacement from calmodulin results in a signal decrease. The changes are ion selective and can be explained using relaxivity theory. The ratio of T[subscript 2] to T[subscript 1] relaxivity is also calcium-dependent, indicating the feasibility of “ratiometric” analyte detection, independent of the probe concentration. Measurement of paramagnetic ion displacement effects could be used to determine analyte ion concentrations with spatial resolution in opaque specimens.National Institutes of Health (U.S.) (grant DP2-OD2441)National Institutes of Health (U.S.) (grant R01-GM65519)McGovern Institute for Brain Research at MIT. Neurotechnology (MINT) Progra
Structural and Electronic Decoupling of C_(60) from Epitaxial Graphene on SiC
We have investigated the initial stages of growth and the electronic structure of C_(60) molecules on graphene grown epitaxially on SiC(0001) at the single-molecule level using cryogenic ultrahigh vacuum scanning tunneling microscopy and spectroscopy. We observe that the first layer of C_(60) molecules self-assembles into a well-ordered, close-packed arrangement on graphene upon molecular deposition at room temperature while exhibiting a subtle C_(60) superlattice. We measure a highest occupied molecular orbital–lowest unoccupied molecular orbital gap of ~ 3.5 eV for the C_(60) molecules on graphene in submonolayer regime, indicating a significantly smaller amount of charge transfer from the graphene to C_(60) and substrate-induced screening as compared to C_(60) adsorbed on metallic substrates. Our results have important implications for the use of graphene for future device applications that require electronic decoupling between functional molecular adsorbates and substrates
Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins
The retromer complex acts as a scaffold for endosomal protein complexes that sort integral membrane proteins to various cellular destinations. The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26. Two of these paralogues, VPS26A and VPS26B, are expressed in humans. Retromer dysfunction is associated with neurodegenerative disease, and recently, three VPS26A mutations (p.K93E, p.M112V, and p.K297X) were discovered to be associated with atypical parkinsonism. Here, we apply quantitative proteomics to provide a detailed description of the retromer interactome. By establishing a comparative proteomic methodology, we identify how this interactome is perturbed in atypical parkinsonism-associated VPS26A mutants. In particular, we describe a selective defect in the association of VPS26A (p.K297X) with the SNX27 cargo adaptor. By showing how a retromer mutant leads to altered endosomal sorting of specific PDZ ligand–containing cargo proteins, we reveal a new mechanism for perturbed endosomal cargo sorting in atypical parkinsonism
Scaling behaviour for the water transport in nanoconfined geometries
The transport of water in nanoconfined geometries is different from bulk phase and has tremendous implications in nanotechnology and biotechnology. Here molecular dynamics is used to compute the self-diffusion coefficient D of water within nanopores, around nanoparticles, carbon nanotubes and proteins. For almost 60 different cases, D is found to scale linearly with the sole parameter theta as D(theta)=DB[1+(DC/DB-1)theta], with DB and DC the bulk and totally confined diffusion of water, respectively. The parameter theta is primarily influenced by geometry and represents the ratio between the confined and total water volumes. The D(theta) relationship is interpreted within the thermodynamics of supercooled water. As an example, such relationship is shown to accurately predict the relaxometric response of contrast agents for magnetic resonance imaging. The D(theta) relationship can help in interpreting the transport of water molecules under nanoconfined conditions and tailoring nanostructures with precise modulation of water mobility
Part 1 – Coronary angiography with gadofosveset trisodium: a prospective feasibility study evaluating injection techniques for steady-state imaging
Physicochemical Characterization, and Relaxometry Studies of Micro-Graphite Oxide, Graphene Nanoplatelets, and Nanoribbons
The chemistry of high-performance magnetic resonance imaging contrast agents remains an active area of research. In this work, we demonstrate that the potassium permanganate-based oxidative chemical procedures used to synthesize graphite oxide or graphene nanoparticles leads to the confinement (intercalation) of trace amounts of Mn2+ ions between the graphene sheets, and that these manganese intercalated graphitic and graphene structures show disparate structural, chemical and magnetic properties, and high relaxivity (up to 2 order) and distinctly different nuclear magnetic resonance dispersion profiles compared to paramagnetic chelate compounds. The results taken together with other published reports on confinement of paramagnetic metal ions within single-walled carbon nanotubes (a rolled up graphene sheet) show that confinement (encapsulation or intercalation) of paramagnetic metal ions within graphene sheets, and not the size, shape or architecture of the graphitic carbon particles is the key determinant for increasing relaxivity, and thus, identifies nano confinement of paramagnetic ions as novel general strategy to develop paramagnetic metal-ion graphitic-carbon complexes as high relaxivity MRI contrast agents
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