3 research outputs found
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Teaching the Harlem Renaissance in the 21st Century
Designed for teachers and community educators, this resource presents student-centered curricula for grades 6-12. Each of the nine modules uses critical inquiry approaches to encourage students’ examination of the materiality of different texts and media as the means for exploring and synthesizing content to arrive at their own new understandings of the Harlem Renaissance.
Teaching the Harlem Renaissance in the 21st Century accompanied the Wallach Art Gallery exhibition, Uptown Triennial 2020 (on view September 24, 2020–February 28, 2021). The resource is the result of a partnership with the Wallach Art Gallery, the Double Discovery Center, and Institute for Urban and Minority Education at Columbia University
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Bacterial polysaccharides suppress induced innate immunity by calcium chelation
Bacterial pathogens and symbionts must suppress or negate host innate immunity. However, pathogens release conserved oligomeric and polymeric molecules or MAMPs (Microbial Associated Molecular Patterns), which elicit host defenses [1], [2] and [3]. Extracellular polysaccharides (EPSs) are key virulence factors in plant and animal pathogenesis, but their precise function in establishing basic compatibility remains unclear [4], [5], [6] and [7]. Here, we show that EPSs suppress MAMP-induced signaling in plants through their polyanionic nature [4] and consequent ability to chelate divalent calcium ions [8]. In plants, Ca2+ ion influx to the cytosol from the apoplast (where bacteria multiply [4], [5] and [9]) is a prerequisite for activation of myriad defenses by MAMPs [10]. We show that EPSs from diverse plant and animal pathogens and symbionts bind calcium. EPS-defective mutants or pure MAMPs, such as the flagellin peptide flg22, elicit calcium influx, expression of host defense genes, and downstream resistance. Furthermore, EPSs, produced by wild-type strains or purified, suppress induced responses but do not block flg22-receptor binding in Arabidopsis cells. EPS production was confirmed in planta, and the amounts in bacterial biofilms greatly exceed those required for binding of apoplastic calcium. These data reveal a novel, fundamental role for bacterial EPS in disease establishment, encouraging novel control strategies