Nuclear light bulb

The nuclear light bulb engine is a closed cycle concept. The nuclear light bulb concept provides containment by keeping the nuclear fuel fluid mechanically suspended in a cylindrical geometry. Thermal heat passes through an internally cooled, fused-silica, transparent wall and heats hydrogen propellant. The seeded hydrogen propellant absorbs radiant energy and is expanded through a nozzle. Internal moderation was used in the configuration which resulted in a reduced critical density requirement. This result was supported by criticality experiments. A reference engine was designed that had seven cells and was sized to fit in what was then predicted to be the shuttle bay mass and volume limitations. There were studies done of nozzle throat cooling schemes to remove the radiant heat. Elements of the nuclear light bulb program included closed loop critical assembly tests done at Los Alamos with UF6 confined by argon buffer gas. It was shown that the fuel region could be seeded with constituents that would block UV radiation from the uranium plasma. A combination of calculations and experiments showed that internal moderation produced a critical mass reduction. Other aspects of the research are presented

Congressman Tom Latham statement

https://scholarworks.uni.edu/postville_documents/1348/thumbnail.jp

Failure in videogames: similarities and differences to textile craft

This paper applies Juul’s (2013) account of failure in videogames to an analysis of hand knitting to argue that there are similarities and differences between videogame play and textile craft practice, specifically through a case study of Unravel (Coldwood Interactive 2016) and Unravel Two (Coldwood Interactive 2018)

An a priori investigation of astrophysical false positives in ground-based transiting planet surveys

Astrophysical false positives due to stellar eclipsing binaries pose one of the greatest challenges to ground-based surveys for transiting Hot Jupiters. We have used known properties of multiple star systems and Hot Jupiter systems to predict, a priori, the number of such false detections and the number of genuine planet detections recovered in two hypothetical but realistic ground-based transit surveys targeting fields close to the galactic plane (b~10 degrees): a shallow survey covering a magnitude range 10<V<13, and a deep survey covering a magnitude range 15<V<19. Our results are consistent with the commonly-reported experience of false detections outnumbering planet detections by a factor of ~10 in shallow surveys, while in our synthetic deep survey we find ~1-2 false detections for every planet detection. We characterize the eclipsing binary configurations that are most likely to cause false detections and find that they can be divided into three main types: (i) two dwarfs undergoing grazing transits, (ii) two dwarfs undergoing low-latitude transits in which one component has a substantially smaller radius than the other, and (iii) two eclipsing dwarfs blended with one or more physically unassociated foreground stars. We also predict that a significant fraction of Hot Jupiter detections are blended with the light from other stars, showing that care must be taken to identify the presence of any unresolved neighbors in order to obtain accurate estimates of planetary radii. This issue is likely to extend to terrestrial planet candidates in the CoRoT and Kepler transit surveys, for which neighbors of much fainter relative brightness will be important.Comment: 33 pages, 7 figures, 4 tables; To be published in The Astrophysical Journa

The relationship between irrigation-induced electrical loads and antecedent weather conditions in Tasmania, Australia

Over the past decade in Australia, there has been a general trend towards the introduction of electrical motors to operate irrigation pumps. While electrical motors provide many advantages over the alternatives, electrical loads can aggregate in some areas to become large peaks, which challenge the existing electrical distribution networks. This is especially true during extreme hot or dry periods, when irrigators collectively demand significant electrical resources at the same time. While there is an inherent link between weather conditions and the amount of electricity used for irrigation, this relationship is poorly understood. Previous studies have either focused on localised data related to concurrent temperature, rainfall and soil moisture, or they have annualised summaries over large areas. In this study, we compare intensive irrigation periods with the drought factor at a case study irrigation scheme in Tasmania, Australia, finding a strong relationship between electrical load and periods when the drought factor is > 6. This relatively simple relationship may be useful for managers of electricity supply and distribution, managers of water resources, and irrigators, as it may be used to minimise the risk of exceeding the capacity of the electricity network, improve water availability and optimise irrigation scheduling

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological regulation of transcription. Using both in vitro and in vivo assays, we show that lactate, which accumulates when glycolysis exceeds the cell’s aerobic metabolic capacity, is an endogenous HDAC inhibitor, deregulating transcription in an HDAC-dependent manner. Lactate is a relatively weak inhibitor (IC(50) 40 mM) compared to the established inhibitors trichostatin A and butyrate, but the genes deregulated overlap significantly with those affected by low concentrations of the more potent inhibitors. HDAC inhibition causes significant up and downregulation of genes, but genes that are associated with HDAC proteins are more likely to be upregulated and less likely to be downregulated than would be expected. Our results suggest that the primary effect of HDAC inhibition by endogenous short-chain fatty acids like lactate is to promote gene expression at genes associated with HDAC proteins. Therefore, we propose that lactate may be an important transcriptional regulator, linking the metabolic state of the cell to gene transcription

Efficacy of a gamified digital therapy for speech production in people with chronic aphasia (iTalkBetter): behavioural and imaging outcomes of a phase II item-randomised clinical trial

Background Aphasia is among the most debilitating of symptoms affecting stroke survivors. Speech and language therapy (SLT) is effective, but many hours of practice are required to make clinically meaningful gains. One solution to this ‘dosage’ problem is to automate therapeutic approaches via self-supporting apps so people with aphasia (PWA) can amass practice as it suits them. However, response to therapy is variable and no clinical trial has yet identified the key brain regions required to engage with word-retrieval therapy. Methods Between Sep 7, 2020 and Mar 1, 2022 at University College London in the UK, we carried out a phase II, item-randomised clinical trial in 27 PWA using a novel, self-led app, ‘iTalkBetter’, which utilises confrontation naming therapy. Unlike previously reported apps, it has a real-time utterance verification system that drives its adaptive therapy algorithm. Therapy items were individually randomised to provide balanced lists of ‘trained’ and ‘untrained’ items matched on key psycholinguistic variables and baseline performance. PWA practised with iTalkBetter over a 6-week therapy block. Structural and functional MRI data were collected to identify therapy-related changes in brain states. A repeated-measures design was employed. The trial was registered at ClinicalTrials.gov (NCT04566081). Findings iTalkBetter significantly improved naming ability by 13% for trained items compared with no change for untrained items, an average increase of 29 words (SD = 26) per person; beneficial effects persisted at three months. PWA’s propositional speech also significantly improved. iTalkBetter use was associated with brain volume increases in right auditory and left anterior prefrontal cortices. Task-based fMRI identified dose-related activity in the right temporoparietal junction. Interpretation Our findings suggested that iTalkBetter significantly improves PWAs’ naming ability on trained items. The effect size is similar to a previous RCT of computerised therapy, but this is the first study to show transfer to a naturalistic speaking task. iTalkBetter usage and dose caused observable changes in brain structure and function to key parts of the surviving language perception, production and control networks. iTalkBetter is being rolled-out as an app for all PWA and anomia: https://www.ucl.ac.uk/icn/research/research-groups/neurotherapeutics/projects/digital-interventions-neuro-rehabilitation-0 so that they can increase their dosage of practice-based SLT

Kepler's Last Planet Discoveries: Two New Planets and One Single-Transit Candidate from K2 Campaign 19

The Kepler space telescope was responsible for the discovery of over 2,700 confirmed exoplanets, more than half of the total number of exoplanets known today. These discoveries took place during both Kepler's primary mission, when it spent 4 years staring at the same part of the sky, and its extended K2 mission, when a mechanical failure forced it to observe different parts of the sky along the ecliptic. At the very end of the mission, when Kepler was exhausting the last of its fuel reserves, it collected a short set of observations known as K2 Campaign 19. So far, no planets have been discovered in this dataset because it only yielded about a week of high-quality data. Here, we report some of the last planet discoveries made by Kepler in the Campaign 19 dataset. We conducted a visual search of the week of high-quality Campaign 19 data and identified three possible planet transits. Each planet candidate was originally identified with only one recorded transit, from which we were able to estimate the planets' radii and estimate the semimajor axes and orbital periods. Analysis of lower-quality data collected after low fuel pressure caused the telescope's pointing precision to suffer revealed additional transits for two of these candidates, allowing us to statistically validate them as genuine exoplanets. We also tentatively confirm the transits of one planet with TESS. These discoveries demonstrate Kepler's exoplanet detection power, even when it was literally running on fumes.Comment: 14 pages, 9 figures, 4 tables. Accepted for publication in MNRA