Comparison of Visual Simultaneous Localization and Mapping Methods for Fixed-Wing Aircraft Using SLAMBench2

Visual Simultaneous Localization and Mapping (VSLAM) algorithms have evolved rapidly in the last few years, however there has been little research evaluating current algorithm\u27s effectiveness and limitations when applied to tracking the position of a fixed-wing aerial vehicle. This research looks to evaluate current monocular VSLAM algorithms\u27 performance on aerial vehicle datasets using the SLAMBench2 benchmarking suite. The algorithms tested are MonoSLAM, PTAM, OKVIS, LSDSLAM, ORB-SLAM2, and SVO, all of which are built into the SLAMBench2 software. The algorithms\u27 performance is evaluated using simulated datasets generated in the AftrBurner Engine. The datasets were designed to test the quality of each algorithm\u27s tracking solution, as well as finding any dependence on camera field of view (FOV), aircraft altitude, bank angle, and bank rate. Through these tests, it was found that LSDSLAM, ORB-SLAM2, and SVO are good candidates for further research, with MonoSLAM, PTAM, and OKVIS failing to track any datasets. All algorithms were found to fail when the capturing camera had a horizontal FOV of less than 60 degrees, with peak performance occurring at a FOV of 75 degrees or above. LSDSLAM was found to fail when the aircraft bank angle exceeded half of the camera\u27s FOV, and SVO was found to fail below 450 meters altitude. The simulations were also tested against a comparable real world dataset, with agreeable results, although the FOV of the real world dataset was too small to be a particularly useful test. Further research is required to determine the applicability of these results to the real world, as well as fuse VSLAM algorithms with other sensors and solutions to form a more robust navigation solution

A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation. All data are available and searchable at http://www.mouseac.org

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which regulates production of toxic amyloid peptides. However, whether BACE1 also plays a role in glucose homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1−/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild-type littermates. BACE1−/− mice are also protected from diet-induced obesity. BACE1-deficient skeletal muscle and liver exhibit improved insulin sensitivity. In a skeletal muscle cell line, BACE1 inhibition increased glucose uptake and enhanced insulin sensitivity. The loss of BACE1 is associated with increased levels of UCP1 (uncoupling protein 1) in BAT (brown adipose tissue) and UCP2 and UCP3 mRNA in skeletal muscle, indicative of increased uncoupled respiration and metabolic inefficiency. Thus BACE1 levels may play a critical role in glucose and lipid homoeostasis in conditions of chronic nutrient excess. Therefore strategies that ameliorate BACE1 activity may be important novel approaches for the treatment of diabetes

Family History of Alcoholism and Childhood Adversity: Joint Effects on Alcohol Consumption and Dependence

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65494/1/j.1530-0277.1994.tb00085.x.pd

Regional variations in British alcohol morbidity rates: a myth uncovered? II: population surveys.

Regional variations in officially recorded rates of alcohol related morbidity in Britain were investigated by surveying community drinking habits of a randomly selected sample of adults in the Highlands, Tayside, and part of the South East Thames region. Contrary to expectations, patterns of alcohol consumption did not differ in a manner consistent with the much higher rates of alcohol related problems recorded in the north

Regional variations in British alcohol morbidity rates: a myth uncovered? I: Clinical surveys.

Officially recorded rates of many alcohol related problems are much higher in the north than in the south of Britain. To try to shed some light on this the pattern and threshold for use of psychiatric and medical hospital services for alcohol dependence, abuse, and psychosis were studied in three areas differing greatly in official rates of alcohol related problems--namely, the Highland and Tayside regions in Scotland and part of the South East Thames region in England. The disparity in psychiatric admissions for alcohol dependence, abuse, and psychosis were found to be largely explained by admission policies which reflected geographical factors. The results of this study did not support the conventional view that rates of treated morbidity due to alcohol are appreciably higher in the north

Self‐Reported Alcohol Consumption and Adverse Consequences of Drinking in Three Areas of Britain: General Population Studies

Official rates of alcohol‐related problems are highest in the North, and lowest in the South of Britain. As pan of a wider study of regional variations, surveys of self‐reported levels of alcohol consumption and adverse consequences of drinking were simultaneously conducted within 3 areas of Britain. These were Highland and Tayside Regions in Scotland, and part of the South East Thames Area Health Board in England. These areas have markedly different rates of alcohol related problems. It was found that these variations were not reflected in differences in either levels or patterns of self‐reported alcohol consumption. It is suggested that care has to be exercised when interpreting official statistics relating to area differences in problem‐drinking. Copyright © 1985, Wiley Blackwell. All rights reserve