Angiotensin II Modulates Podocyte Glucose Transport

Podocytes play a central role in the maintenance of the glomerular filtration barrier and are cellular targets of angiotensin II (AngII). Non-hemodynamic pathways of AngII signaling regulate cellular function and mediate podocyte abnormalities that are associated with various glomerulopathies, including diabetic kidney disease. In this study we investigated the capacity of AngII to modulate glucose uptake in mouse podocytes expressing the human AT1 receptor (AT1R+) after 5 days of exposure to normal (NG, 5.6 mmol/L) or to high (HG, 30 mmol/L) glucose. Short (30 min) as well as long-term (24 h) incubations with AngII markedly enhanced glucose transport in both NG and HG cells. In podocytes cultured under NG conditions, AngII inhibited insulin-stimulated glucose uptake. Regardless of the presence or absence of AngII, no effect of insulin on glucose uptake was observed in HG cells. Stimulation of glucose transport by AngII was mediated by protein kinase C and by phosphoinositide 3-kinase. Glucose dependent surface expression of the glucose transporters GLUT1, GLUT2, and GLUT4 was modulated by AngII in a time and glucose concentration dependent manner. Furthermore, despite its inhibitory effect on insulin's action, AngII elevated the number of podocyte insulin receptors in both NG and HG cultured cells. These findings demonstrate that AngII modulates podocyte basal, as well as insulin-dependent glucose uptake by regulating glucose transporters and insulin signaling

Methodical aspects of soil ecosystem services valuation

Ecosystem Services Valuation is an important tool for dialogue in the decision-making process and to highlight the society’s dependence on the biosphere for well-being. Soil is the primary source of ecosystem services such as the production of food and regulating the climate, however the methodological alternatives for valuing soil ecosystem services remain poorly studied. The aim of this paper is to demonstrate methodical aspects of ecosystem services valuation, with the special attention to soil services within agricultural context. We introduce frameworks specific for soil ecosystem services. Then, we present a case study where soil ecosystem services were evaluated within agricultural context. We conclude that such valuation represents the newest trend in soil science wherein soil resources are treated in the wider context of impacts on human well-being

Searching for solutions to the conflict over Europe's oldest forest

The Białowieża Forest World Heritage site is one of the last remaining primeval forests in lowland Europe and is a refuge for European Bison (Bison bonasus), the largest land mammal on the continent (Table 1)

A reconnaissance-scale GIS-based multicriteria decision analysis to support sustainable biochar use: Poland as a case study

Although increasing numbers of research papers regarding biochar are being published worldwide, in some countries growing interest in biochar has only recently been observed; this is true of Poland. We analysed information on biochar research in Poland alongside lessons learned elsewhere in order to identify the significant opportunities and risks associated with biochar use. This data fed into a GIS-based multicriteria analysis to identify areas where biochar application could deliver greatest benefit. We found that 21.8% of agricultural land in Poland has at least moderate indication for biochar use (soil organic matter below 2% and pH below 5.5), while 1.5% was categorized as a priority as it also exhibited contamination. Potential barriers identified included biomass availability and associated risks of indirect land-use change due to possible national and transnational biomass production displacement. Biochar use could have positive global consequences as a climate change mitigation strategy, particularly relevant in a country with limited alternatives. Scaling up a mitigation technology that is viable on account of its co-benefits might be cost-effective, which could, in turn, adjust national perspectives and stronger involvement in developing mitigation policies at the regional level. Biochar has much promise in temperate conditions and further research should therefore be assigned to explore biochar’s environmental and socio-economic impacts

Willingness to Adopt Biochar in Agriculture: The Producer’s Perspective

Most research on biochar has focused either on the mechanistic or the biophysical aspects, and there has been relatively little research into the social applicability and acceptance of biochar as a soil enhancer in agriculture. However, whether to adopt biochar in their practice is ultimately the farmers’ decision, and their willingness to do so is crucial. Here, we show the producer’s perspective on adopting biochar, using Polish farmers as a case study. Poland is an interesting case study because biochar has only recently attracted the attention of researchers, entrepreneurs, and other stakeholders there. We performed standardized, semi-structured interviews with 161 Polish farmers to evaluate the socioeconomic potential of biochar application in practice. We found that 27% of the respondents claimed to be familiar with biochar. The respondents with a technical, non-agricultural level of education were most familiar with the term ‘biochar’ (36%), followed by the group of respondents with a higher-level agricultural education (31%). It was surprising that among the latter respondents, the majority (69%) did not know the term ‘biochar’, either in the context used for this study or in any other context. Twenty percent of the respondents expressed an interest in using biochar, while 43% were not willing to adopt it in their agricultural practice (37% ‘did not know yet’). If a farmer was familiar with the concept of sustainable agriculture, the probability of familiarity with biochar increased by 16% (p < 0.05). In addition, farmers interested in using biochar indicated that sustainable agriculture might improve the financial situation of their farms (52%). The perceived benefits of biochar that drive the willingness to adopt it included improved soil quality and increased income due to increased yields, while the constraints on its adoption were associated mainly with high costs. Our results also point to the necessity of information flow as well as engaging farmers in participatory research to adjust the research to their needs. Furthermore, our results highlight the importance of transparency with the farmers and appropriate dissemination and presentation of both the positive and the negative aspects of biochar adoption. We urge those studying biochar to engage in more interdisciplinary research and to go beyond laboratory and field research. Many innovations, even those that work, will not be adopted if socioeconomic considerations are not incorporated into the research

Capturing a soil carbon economy

Current carbon pricing and trading mechanisms, despite their efficacy in reducing GHG emissions from industry, will not be sufficient to achieve Net Zero targets. Current mechanisms that redress emissions are largely economic disincentives, in effect financial penalties for emitters. In order to attain Net Zero futures, financial incentives for activities that sequester carbon from the atmosphere are needed. Herein, we present the environmental and economic co-benefits of soil re-carbonization and justify support for soil carbon remuneration. With increasing momentum to develop green economies, and projected increases in carbon price, growth in the global carbon market is inevitable. The establishment of a soil-based carbon economy, within this emerging financial space, has the potential to deliver a paradigm shift that will accelerate climate change mitigation, and concurrently realize net gains for soil health and the delivery of soil ecosystem services. Pivotal to the emergence of a global soil carbon economy will be a consensus on certification instruments used for long-term soil carbon storage, and the development of robust institutional agreements and processes to facilitate soil carbon trading

Evaluating nature-based solutions for water management in peri-urban areas

The term nature-based solutions (NBS) has gained traction in recent years and has been applied in many settings. There are few comprehensive assessment frameworks available that can guide NBS planning and implementation while at the same time capturing the short- and long-term impacts and benefits of the NBS. Here a recently presented framework, which builds on the theory of change and was developed to assess NBS at different phases of the project cycle, was applied to seven diverse case studies. The case studies addressed water quality and quantity issues in peri-urban areas across the global north and south. Framework indicators covering the sustainability dimensions (environmental, social and economic) were assessed at three stages of the framework: context, process and results. The work sought to investigate the following research objectives: (1) Can this framework be robust and yet flexible enough to be applied across a diverse selection of NBS projects that are at different phases of the project cycle and address different kinds of water challenges within varied ecological, social and economic contexts? (2) Is it possible to draw generalisations from a comparative analysis of the application of the framework to the case studies? Results showed that the framework was able to be applied to the case studies; however, their diversity showed that NBS projects designed in one context, for a specific purpose in a specific location, can not necessarily be transferred easily to another location. There were several process-based indicators that were universally significant for the case studies, including expertise, skills and knowledge of the involved actors, roles and responsibilities of involved actors and political support. The result-based indicators were case study-specific when environmental indicators were case study-specific, and important social indicators were environmental identity and recreational values. Overall, the use of the framework benefits the recognition of the implementation’s advances, such as the change in context, the processes in place and the results obtained.The authors would like to thank the European Commission and the Research Council of Norway (RCN-project number 300560), Swedish Research Council for Sustainable Development (FORMAS-project number 2018-02777), the Water Research Commission (WRC) in South Africa (Project: 2019/2020-00034) and Spain Ministry of Science and Innovation (MCIU/AEI/FEDER) (PCI2019- 103674,2019), for funding the research in the frame of the collaborative international consortium NATWIP financed under the 2018 Joint Call of theWaterWorks2017 ERA-NET Cofund. This ERA-NET is an integral part of the activities developed by the Water JPI. We also acknowledge the International Institute for Sustainability for providing an in-kind contribution to this research. We also acknowledge that AEL received a grant from the Newton Advanced Fellowship (NAF/R2/18676), CAPES (001), CNPQ (308536/2018-5), FAPERJ (E-26/202.680/2018).Peer ReviewedPostprint (published version

Characterising the spatial distribution of opportunities and constraints for land sparing in Brazil

Abstract: Brazil is a megadiversity country with more tropical forest than any other, and is a leading agricultural producer. The technical potential to reconcile these roles by concentrating agriculture on existing farmland and sparing land for nature is well-established, but the spatial overlap of this potential with conservation priorities and institutional constraints remains poorly understood. We mapped conservation priorities, food production potential and socio-economic variables likely to influence the success of land sparing. Pasture occupies 70% of agricultural land but contributes ≤11% of the domestic food supply. Increasing yields on pasture would add little to Brazil’s food supply but – if combined with concerted conservation and restoration policies – provides the greatest opportunities for reducing land demand. Our study illustrates a method for identifying municipalities where land-sparing policies are most likely to succeed, and those where further effort is needed to overcome constraints such as land tenure insecurity, lack of access to technical advice, labour constraints, and non-compliance with environmental law

When enough should be enough: Improving the use of current agricultural lands could meet production demands and spare natural habitats in Brazil

Providing food and other products to a growing human population while safeguarding natural ecosystems and the provision of their services is a significant scientific, social and political challenge. With food demand likely to double over the next four decades, anthropization is already driving climate change and is the principal force behind species extinction, among other environmental impacts. The sustainable intensification of production on current agricultural lands has been suggested as a key solution to the competition for land between agriculture and natural ecosystems. However, few investigations have shown the extent to which these lands can meet projected demands while considering biophysical constraints. Here we investigate the improved use of existing agricultural lands and present insights into avoiding future competition for land. We focus on Brazil, a country projected to experience the largest increase in agricultural production over the next four decades and the richest nation in terrestrial carbon and biodiversity. Using various models and climatic datasets, we produced the first estimate of the carrying capacity of Brazil's 115 million hectares of cultivated pasturelands. We then investigated if the improved use of cultivated pasturelands would free enough land for the expansion of meat, crops, wood and biofuel, respecting biophysical constraints (i.e., terrain, climate) and including climate change impacts. We found that the current productivity of Brazilian cultivated pasturelands is 32–34% of its potential and that increasing productivity to 49–52% of the potential would suffice to meet demands for meat, crops, wood products and biofuels until at least 2040, without further conversion of natural ecosystems. As a result up to 14.3 Gt CO2 Eq could be mitigated. The fact that the country poised to undergo the largest expansion of agricultural production over the coming decades can do so without further conversion of natural habitats provokes the question whether the same can be true in other regional contexts and, ultimately, at the global scale