An effort to make sense of antisense transcription in bacteria

Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5'- and 3'-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed

Factors associated with quality of life among adult patients with Type 2 Diabetes Mellitus

The prevalence of Type 2 Diabetes Mellitus (T2DM) in Malaysia is increasing. It is essentials to assess the quality of life (QoL) of T2DM to measure outcome of T2DM for better care and control of the disease. This study aimed to determine the factors associated with QoL among adult patients with T2DM. A cross-sectional study was conducted among patients attending diabetic clinic in Seremban 2 Health Clinic. Patients were selected using systematic random sampling method and data collection gathered by self-administered questionnaire. SF-36 was used for assessing the QoL which has 8 health domains and 2 component summaries that incorporated both physical and mental component. The response rate was 89%. QoL were found significantly associated with socio-demographic factors such as age (PF: p=0.043), gender (PF: p<0.001, BP: p=0.013 & PCS: p=0.007), ethnicity (BP: p=0.03), education level (RP: p=0.006, GH: p=0.038, VT: p=0.009, RE: p=0.012, MH: p=0.001, PCS: p=0.037, & MCS: p<0.001), marital status (VT: p=0.027), and employment status (PF: p<0.001, RP: p<0.001, GH: p<0.001 & VT: p=0.041). Lower QoL scores were observed in older age group, females gender, lower education, divorced/widowed and unemployed. Clinical profiles such as diabetic duration (PF: p=0.005, RP: p=0.033, GH: p=0.004, RE: p=0.044 and PCS (p=0.003), and presence of co-morbidity (PF: p=0.012) were also significantly associated with QoL in various SF-36 domains. Type of treatment was significantly associated with QoL in all domains (p<0.05) except in BP. Glycemic control significantly associated with QoL in RP (p=0.008), BP (p=0.002), GH (p=0.003), RE (p=0.009), PCS (p=0.001), and MCS (p=0.017). Diabetic complication was significantly associated with all the 8 health domains and 2 component summaries (p<0.01). In conclusion, socio-demographic, diabetic complication, co-morbidity, duration, treatment types and glycemic control were found to be associated with QoL among T2DM patients

Computational fluid dynamics study of crec riser simulator: mixing patterns

The CREC Riser Simulator Reactor is a novel mini-fluidized reactor. This novel device was invented by de Lasa 1. The applications of this unit has shown to be of great value to establish catalyst performance and kinetic models for a diversity of gas phase catalytic reactions. This has been the case, given that the CREC Riser Simulator is excellent with respect to particle and fluid mixing2. This study establishes using CFD (Computational Fluid Dynamics), the CREC Riser Simulator mixing flow patterns. CFD simulations were developed using the COMSOL Multiphysics® module. Fig.1a reports the geometric characteristics of the CREC Riser Simulator including the impeller, the basket containing the catalyst and the external baffles.The proposed CFD model was validated using experimental data obtained in a basket as shown in Fig.1a. For instance, for an impeller speed of 4000 rpm, the outer annulus experimental gas velocity2 was ~0.9 m/s and the simulated CFD gas velocity2 was ~1.3 m/s. Please click Additional Files below to see the full abstract

Isi dan kelengkapan rumah tangga tradisional menurut tujuan, fungsi dan kegunaannya daerah Jawa Tengah

Naskah ini meneliti isi dan kelengkapan rumah tangga tradisional, yaitu sejumlah benda yang dibutuhkan oleh setiap rumah tangga yang masih kuat memegang atau mempertahankan adat istiadat lama dalam usahanya untuk memenuhi kebutuhan hidupnya baik kebutuhan jasmani maupun spiritual serta peranan dari pada setiap benda yang dimiliki oleh setiap rumah tangga tersebut. Dalam hal ini sebagai samplenya dipilih dua desa tradisional yang dapat dianggap mewakili beberapa desa tradisional di daerah Jawa Tengah. yaitu satu desa (Desa Plantungan) yang masih sedikit atau boleh dikatakan hampir belum mendapat pengaruh dari perkembangan teknologi modern sebagai akibat dari letaknya yang jauh dari kota dan sukar dijangkau dengan kendaraan atau jaringan komunikasi lainnya, dan satu desa (Desa Jepangrejo) yang sudah mendapat pengaruh dari perkembangan teknologi modern karena disamping letaknya lebih dekat dengan kota juga dapat terjangkau oleh jaringan komunikasi

Epístola moral a Fabio : fuentes y sentido

En este trabajo se analizan las fuentes de la "Epístola moral a Fabio", deteniéndose en las formas y contenidos, así como en la serie de temas e imágenes que propiciarán la creación de la obra. Para ello, se traza un arco cronológico, desde Fernando de Herrera y Jerónimo de Lomas Cantoral hasta autores contemporáneos como Juan de Arguijo, Francisco de Medrano y Francisco de Rioja. El objetivo es demostrar que alrededor de 1610 existía en la ciudad de Sevilla un completo caldo de cultivo en metros, imágenes y formas a partir de los cuales, surgirá la obra del Capitán Andrada.This paper analyses the sources of "Fabio's moral epistole letter", focusing on both its forms and contents as well as on the range of themes and metaphorical images that made its possible the creating of this book. It is my intention to cutline a chronological spectrum going form Fernando de Herrera and Jerónimo de Lomas Cantoral until contemporary authors such as Juan de Arguijo, Francisco de Medrano and Francisco de Rioja. The main objective is to prove that, around 1610, there existed already a complex breeding ground regarding poetic meters, images and forms from which this book could appear

Contribuição ao estudo da mudança tecnológica em sociedades caçadorascoletoras: um enfoque integrador

Aportes al estudio del cambio tecnológico en sociedades cazadoras-recolectoras: Un enfoque integrador. El objetivo del presente trabajo es llevar a cabo una contextualización crítica del cambio tecnológico y su abordaje en sociedades con economía de caza y recolección. En una primera instancia se describen cuáles son los factores o causas que generan transformaciones en las prácticas sociales, con una revisión profunda sobre el rol del ambiente. En segundo lugar, se definen variables y/o criterios a nivel material (artefacto, materia prima, sitio) para identificar el cambio o innovaciones tecnológicas. Por último, para plasmar la perspectiva aquí planteada se propone como caso de estudio el de las sociedades cazadoras-recolectoras que habitaron el área Interserrana Bonaerense durante el Holoceno medio y tardío.The aim of this paper is to show a critical contextualization of technological change and its analysis in hunter/gatherer societies. First of all we describe what factors or causes generate changes in social practices. Subsequently, material criteria (artifact, raw material, site) will be defined to identify technological changes. Finally, it is proposed as a case of study of hunter-gatherer societies that inhabited the Interserrana area (Buenos Aires province) during the middle and late Holocene.L’objectif de ce travail est la contextualisation critique du changement technologique et son étude dans les sociétés d'économie chasseuse-cueilleuse. En premier lieu, on a décrit les principaux facteurs o causes que génèrent transformations dans les pratiques sociales, particulièrement celles liées aux variables environnementales. Deuxièmement, on a défini les critères matériaux (artéfact, matière première, site) pour identifier les changements o innovations technologiques. Finalement, pour exprimer la perspective proposée dans ce texte, on présente un cas d'étude lié aux sociétés du chasseurscueilleurs qui ont habité la région inter-montagnarde de Buenos Aires pendant l'Holocène moyen et tardive.O objetivo do presente trabalho é fazer uma contextualização crítica da mudança tecnológica em sociedades com economia de caça e coleta. Em primeiro lugar são descritos quais são os fatores ou causas que geram transformações nas práticas sociais, com uma revisão profunda no papel do ambiente. Em segundo, são definidas as variáveis e os critérios a nivel material (artefato, materia prima, sítios) para identificar as mudanças ou inovaçes tecnológicas. Por último, para atender à perspectiva colocada é apresentado como estudo de caso as sociedades caçadoras-coletoras que habitaram a área Inter serrana Bonaerense durante o Holoceno médio e tardio.Fil: Pal, Nélida Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Alvarez, Myrian Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Briz I Godino, Ivan. University Of York; Reino UnidoFil: Lasa, Adriana Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentin

Temperature dependence of underdense nanostructure formation in tungsten under helium irradiation

Recently, tungsten has been found to form a highly underdense nanostructured morphology ("W fuzz") when bombarded by an intense flux of He ions, but only in the temperature window 900-2000 K. Using object kinetic Monte Carlo simulations (pseudo-3D simulations) parameterized from first principles, we show that this temperature dependence can be understood based on He and point defect clustering, cluster growth, and detrapping reactions. At low temperatures (2300 K), all He is detrapped from clusters, preventing the formation of the large clusters that lead to fuzz growth in the intermediate temperature range. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

Impacto del proceso de enseñanza endoscópica en la detección de adenomas colónicos

ResumenAntecedentesEl impacto que el proceso de entrenamiento endoscópico ejerce sobre la calidad de la colonoscopia en un medio hispanoamericano es escasa.ObjetivoDeterminar el efecto del entrenamiento en la técnica de colonoscopia sobre la detección de adenomas.Materiales y métodosEntre julio del 2012 y julio del 2013, 3 médicos recibieron entrenamiento en colonoscopia por parte de 4 endoscopistas experimentados; Las colonoscopias realizadas por endoscopistas en entrenamiento supervisados fueron comparadas con aquellas realizadas por endoscopistas experimentados.ResultadosSe incluyeron 318 colonoscopias realizadas por alguno de los 3 endoscopistas en entrenamiento bajo supervisión y 367 realizadas por alguno de los endoscopistas entrenados. El análisis univariado mostró una diferencia no significativa en la tasa de detección de adenomas (30.4 vs. 24.7%; p = 0.09). En el análisis multivariado, la tasa de detección de adenomas fue significativamente mayor en las colonoscopias realizadas por alguno de los 3 endoscopistas en entrenamiento (odds ratio = 1.72 [1.19-2.48]).ConclusiónEl involucramiento de endoscopistas en formación tiene un efecto positivo sobre la detección de adenomas.AbstractBackgroundThere has been little reported experience in the Latin American hospital setting in relation to the impact of the endoscopic training process on colonoscopy quality.AimsTo determine the effect that training in the technique of colonoscopy has on adenoma detection in an Argentinian teaching hospital.Material and methodWithin the time frame of July 2012 and July 2013, 3 physicians received training in colonoscopy from 4 experienced endoscopists. The colonoscopies performed by the supervised trainees were compared with those carried out by the experienced endoscopists.ResultsA total of 318 colonoscopies performed by any one of the 3 supervised trainees and 367 carried out by any one of the experienced endoscopists were included. The univariate analysis showed a non-significant difference in the detection rate of adenomas (30.4 vs. 24.7%, P=.09). In the multivariate analysis, the detection rate of adenomas was significantly higher in the colonoscopies performed by one of the 3 trainees (odds ratio = 1.72 [1.19-2.48]).ConclusionsThe supervised involvement of endoscopic trainees has a positive effect on adenoma detection

Kad pogledam svijet - Zbornik radova Međunarodne studije, Vol. I., 2000.

Zbornik radova Međunarodne studije, Vol. I., 2000. Hrvatska udruga za međunarodne studije, Zagreb i Golden Marketing, Zagreb