Mental Health Services in Mexico

The history of mental health services in Mexico is traced from the time of the Spanish conquest to modern times. The present structure of mental health services is outlined as it relates to the overall social services and health\care system in Mexico. Inpatient, aftercare, partial hospitalization, and outpatient service are outlined and described. Levels of service and distribution of facilities and staff by region are given. Methods of intervention are described from traditional healers, to highly specialized modern psychiatry, to innovative community self-management programs. Key issues in the future are financial resources, distribution of services and staff, and ways to optimally use human resources

The one year fate of iron oxide coated gold nanoparticles in mice

Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate

Dissemination of Clonally Related Escherichia coli Strains Expressing Extended-Spectrum β-Lactamase CTX-M-15

E. coli ST131 and ST405 and multidrug-resistant IncFII plasmids may determine spread of this lactamase

Latino Families in the Perinatal Period: Cultural Issues in Dealing with the Health-Care System

Migration of young Latinos and Latinas has increased in many towns in the Midwest. These young people will experience the perinatal period in a new cultural environment. We focus on the interface between families of Latino origin and the Midwest health-care system, particularly in the care of the pregnant woman or couple and in the care of the infant. Issues of culture are central in the perinatal period, and often the staff in health-care centers is not aware of the importance of several traditional and folk health-care beliefs in this period. These beliefs impact the care of the pregnant woman, the baby, and the couple\u27s conception of health and illness, as well as the remedies to solve problems. We review, from the mother and infant mental and physical health point of view, the main culturally based health beliefs and precautions and the culture-bound conditions in pregnancy and for the baby

Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs

International audienceMagnetic hyperthermia mediated by magnetic nanomaterials is one promising antitumoral nanotherapy, particularly for its ability to remotely destroy deep tumors. More and more new nanomaterials are being developed for this purpose, with improved heat-generating properties in solution. However, although the ultimate target of these treatments is the tumor cell, the heating efficiency, and the underlying mechanisms, are rarely studied in the cellular environment. Here we attempt to fill this gap by making systematic measurements of both hyperthermia and magnetism in controlled cell environments, using a wide range of nanomaterials. In particular, we report a systematic fall in the heating efficiency for nanomaterials associated with tumour cells. Real-time measurements showed that this loss of heat-generating power occurred very rapidly, within a matter of minutes. The fall in heating correlated with the magnetic characterization of the samples, demonstrating a complete inhibition of the Brownian relaxation in cellular conditions

Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring

International audienceThe long-term fate of nanomaterials in biological environment represents a critical matter, which determines environmental effects and potential risks for human health. Predicting these risks requires understanding of nanoparticle transformations, persistence, and degradation, some issues somehow ignored so far. Safe by design, inorganic nanostructures are being envisioned for therapy, yet fundamental principles of their processing in biological systems, change in physical properties, and in situ degradability have not been thoroughly assessed. Here we report the longitudinal visualization of iron oxide nanocube transformations inflicted by the intracellular-like environment. Structural degradation of individual nanocubes with two different surface coatings (amphiphilic polymer shell and polyethylene glycol ligand molecules) was monitored at the atomic scale with aberration-corrected high-resolution transmission electron microscopy. Our results suggest that the polymer coating controls surface reactivity and that availability and access of chelating agents to the crystal surface govern the degradation rate. This in situ study of single nanocube degradation was compared to intracellular transformations observed in mice over 14 days after intravenous injection, revealing the role of nanoparticle clustering, intracellular sorting within degradation compartments, and iron transfer and recycling into ferritin storage proteins. Our approach reduces the gap between in situ nanoscale observations in mimicking biological environments and in vivo real tracking of nanoparticle fate

Water-Soluble Iron Oxide Nanocubes with High Values of Specific Absorption Rate for Cancer Cell Hyperthermia Treatment

Iron oxide nanocrystals (IONCs) are appealing heat mediator nanoprobes in magnetic-mediated hyperthermia for cancer treatment. Here, specific absorption rate (SAR) values are reported for cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach in a size range between 13 and 40 nm. The SAR values were determined as a function of frequency and magnetic field applied, also spanning technical conditions which are considered biomedically safe for patients. Among the different sizes tested, IONCs with an average diameter of 19 ± 3 nm had significant SAR values in clinical conditions and reached SAR values up to 2452 W/g_Fe at 520 kHz and 29 kAm^–1, which is one of the highest values so far reported for IONCs. <i>In vitro</i> trials carried out on KB cancer cells treated with IONCs of 19 nm have shown efficient hyperthermia performance, with cell mortality of about 50% recorded when an equilibrium temperature of 43 °C was reached after 1 h of treatment