NLMEModeling: A Wolfram Mathematica Package for Nonlinear Mixed Effects Modeling of Dynamical Systems

Nonlinear mixed effects modeling is a powerful tool when analyzing data from several entities in an experiment. In this paper, we present NLMEModeling, a package for mixed effects modeling in Wolfram Mathematica. NLMEModeling supports mixed effects modeling of dynamical systems where the underlying dynamics are described by either ordinary or stochastic differential equations combined with a flexible observation error model. Moreover, NLMEModeling is a user-friendly package with functionality for model validation, visual predictive checks and simulation capabilities. The package is freely available and provides a flexible add-on to Wolfram Mathematica

Determinants for a low health-related quality of life in asthmatics

People with asthma suffer from impaired health-related quality of life (HRQL), but the determinants of HRQL among asthmatics are not completely understood. The aim of this investigation was to study determinants of low HRQL in asthmatics and to study whether the determinants of HRQL differ between sexes and age groups. A cohort of three age groups in Sweden was investigated in 1990 using a questionnaire with focus on respiratory symptoms. To study quality of life, the generic instrument Gothenburg Quality of Life was used. The participants were also investigated with interviews, spirometry, and allergy testing. Asthma was diagnosed in 616 subjects. Fifty-eight per cent (n = 359) of the subjects were women; and 24% were smokers, 22% ex-smokers, and 54% were non-smokers. Women were more likely than men to report poor health-related quality of life. Respiratory symptoms severity was another independent determinant of a lower quality of life as well as airway responsiveness to irritants. Current and former smokers also reported lower quality of life. Finally, absenteeism from school and work was associated with lower quality of life. Factors such as sex, smoking habits, airway responsiveness to irritants, respiratory symptom severity, allergy, and absenteeism from school and work were associated with low HRQL in asthmatics

Multi-wavelength polarimetric study towards the open cluster NGC 1893

We present multi-wavelength linear polarimetric observations for 44 stars of the NGC 1893 young open cluster region along with V-band polarimetric observations of stars of other four open clusters located between l ~160 to ~175 degree. We found evidence for the presence of two dust layers located at a distance of ~170 pc and ~360 pc. The dust layers produce a polarization Pv ~2.2%. It is evident from the clusters studied in the present work that, in the Galactic longitude range l ~160 to 175 degree and within the Galactic plane (|b| < 2 degree), the polarization angles remain almost constant, with a mean ~163 degree and a dispersion of 6 degree. The small dispersion in polarization angle could be due to the presence of uniform dust layer beyond 1 kpc. Present observations reveal that in case of NGC 1893, the foreground two dust layers, in addition to the intracluster medium, seems to be responsible for the polarization effects. It is also found that towards the direction of NGC 1893, the dust layer that exists between 2-3 kpc has a negligible contribution towards the total observed polarization. The weighted mean for percentage of polarization (Pmax) and the wavelength at maximum polarization ({\lambda}max) are found to be 2.59 \pm 0.02% and 0.55 \pm 0.01 \mum respectively. The estimated mean value of {\lambda}max indicates that the average size of the dust grains within the cluster is similar to that in the general interstellar medium. The spatial variation of the polarization is found to decrease towards the outer region of the cluster. In the present work, we support the notion, as already has been shown in previous studies, that polarimetry, in combination with (U-B)/(B-V) colour-colour diagram, is a useful tool for identifying non-members in a cluster.Comment: 36 pages, 12 figures, 10 tables, accepted for the publication in MNRA

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, Pless than0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.Funding Agencies|European Commission [QLG1-CT-2002-00896]; Swedish Heart-Lung Foundation; Swedish Research Council [8691, 0593]; Knut and Alice Wallenberg Foundation; Foundation for Strategic Research; Stockholm County Council [592229]; Karolinska Institutet; Stockholm County Council; European Union Framework Programme 7 for the Innovative Medicine Initiative [IMI/115006]; Academy of Finland [110413]; British Heart Foundation [RG2008/08, RG2008/014]; Italian Ministry of Health (Ricerca Corrente); Uppsala University; Uppsala University Hospital; Swedish Research Council for Infrastructures; Swedish Heart-Lung Foundation [20120600, 20130399]; Tore Nilsson foundation; Gamla Tjanarinnor foundation; Thurings foundation; Stiftelsen for Gamla Tjanarinnor; Ake Wiberg foundation; Tore Nilssons foundation; Magnus Bergvall Foundation; Foundation for Old Servants; Ministry of Education and Culture in Finland; Vasterbotten County Council; Swedish Heart and Lung Foundation; National Excellence Program [TAMOP 4.2.4.A/1-11-1-2012-0001]; European Union; European Social Fund; UK Medical Research Council [K013351]; Economic and Social Research Council; Academy of Finland; University College London Genetics Institute</p

Optical Imaging of Nova Shells and the Maximum Magnitude-Rate of Decline Relationship

An optical imaging study of recent 30 novae has been undertaken using both ground-based and space-based observations. Resolved shells have been detected around 9 objects in the ground-based data, while another four objects have shells detected by HST observations; for RW UMi, we fail to detect a shell which was observed five years earlier. Images in H-alpha, and when appropriate [O III], are shown, and finding charts for novae without shells are given if no published chart is available. Expansion parallaxes for all systems with shells are derived, and absolute magnitudes for a total of 28 objects are presented, along with a discussion of the maximum magnitude-rate of decline relation. We find that separate linear fits for fast and slow novae may be a better representation of the data than a single, global fit. At minimum, most novae have similar magnitudes as those of dwarf novae at maximum and novalike stars.Comment: 39 pages, 5 ps-figures, 13 jpg-figures. Accepted for publication in the Astronomical Journal (October 2000