96 research outputs found
Developing Methods and Algorithms for Cloud Computing Management Systems in Industrial Polymer Synthesis Processes
To date, the resources and computational capacity of companies have been insufficient to evaluate the technological properties of emerging products based on mathematical modelling tools. Often, several calculations have to be performed with different initial data. A remote computing system using a high-performance cluster can overcome this challenge. This study aims to develop unified methods and algorithms for a remote computing management system for modelling polymer synthesis processes at a continuous production scale. The mathematical description of the problem-solving algorithms is based on a kinetic approach to process investigation. A conceptual scheme for the proposed service can be built as a multi-level architecture with distributed layers for data storage and computation. This approach provides the basis for a unified database of laboratory and computational experiments to address and solve promising problems in the use of neural network technologies in chemical kinetics. The methods and algorithms embedded in the system eliminate the need for model description. The operation of the system was tested by simulating the simultaneous statement and computation of 15 to 30 tasks for an industrially significant polymer production process. Analysis of the time required showed a nearly 10-fold increase in the rate of operation when managing a set of similar tasks. The analysis shows that the described formulation and solution of problems is more time-efficient and provides better production modes. Doi: 10.28991/esj-2021-01324 Full Text: PD
Decoupling of heavy quarks in HQET
Decoupling of c-quark loops in b-quark HQET is considered. The decoupling
coefficients for the HQET heavy-quark field and the heavy-light quark current
are calculated with the three-loop accuracy. The last result can be used to
improve the accuracy of extracting f_B from HQET lattice simulations (without
c-quark loops). The decoupling coefficient for the flavour-nonsinglet QCD
current with n antisymmetrized gamma-matrices is also obtained at three loops;
the result for the tensor current (n=2) is new.Comment: JHEP3 documentclass; the results in a computer-readable form can be
found at http://www-ttp.physik.uni-karlsruhe.de/Progdata/ttp06/ttp06-25/ V2:
a few typos corrected, a few minor text improvements, a few references added;
V3: several typos in formulas fixe
Genome-Wide Association Study Identifies CDKN1A as a Novel Locus Associated with Muscle Fiber Composition
departmental bulletin pape
Genetic profile of sports climbing athletes from three different ethnicities
This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the meta-analysis on three cohorts showed that the frequency of XX + RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities
Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = -0.216, p < 0.001; AC: r = -0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes
Riistaeläinten populaatioiden dynamiikka Pohjois-Euroopassa: tiivistelmä : 7. kansainvälinen symposium. 24. – 28. Syyskuuta
We have studied Black Grouse population abundance and its dynamics in large regions of North-Europe and Urals’ taiga (Finland, Russian Karelia, Murmansk, Arhangel, Kirov and Komi regions and). The data is based on Winter Track Counts (WTC, Priklonski, 1973), where all grouse sightings are recorded. We also studied the longterm Black Grouse abundance changes in Russian and Belarus Natural Reserves (by “Chronical of Natural” Programme, including summer counts of forest grouses): Pinezhsky, Pechoro-Ilychskiy, National Park "Mechera", Nature Reserve "Kivach", "Bryansk Forest", Kostomuksha Nature Reserve Volzhsko-Kamsky National Nature Biosphere Reserve and Visimskiy State Nature Reserves. The highest and most stable abundances of Black Grouse were recorded from East Fennoscandia (Karelia – 3.6 birds per 10 km; Finland – 4.4, coefficient of variation – 12% and 27%, respectively), whereas in the Murmansk and Arkhangelsk Regions and Komi republic, e.g. the species abundance indices were 0.5, 2.5 and 1.1 birds per 10 km, respectively. The “Peak” and minimal abundance years do not concur in different regions of north-European taiga. In Komi in the period from 2001 to 2013, the number of the black grouse declined twice, in Arhangel in the period 30 years – decreased fivefold. In Tatarstan Republic (Volzhsko-Kamsky National Nature Biosphere Reserve) after 1980 abundance decreased rapidly and at last 10 tears – disappeared. In Central Siberia BG are small in numbers and rare. The data suggest Black Grouse abundance varies significantly across Northern Eurasia and among years. One may presume there are some factors acting in different directions: towards convergence and towards divergence of the trends.Peer reviewe
Simultaneous decoupling of bottom and charm quarks
We compute the decoupling relations for the strong coupling, the light quark
masses, the gauge-fixing parameter, and the light fields in QCD with heavy
charm and bottom quarks to three-loop accuracy taking into account the exact
dependence on . The application of a low-energy theorem allows the
extraction of the three-loop effective Higgs-gluon coupling valid for
extensions of the Standard Model with additional heavy quarks from the
decoupling constant of .Comment: 30 page
Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism.
The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of elite European athletes using GWAS approach, followed by replication studies in Russian and Japanese elite athletes and functional validation using metabolomics analysis. The association of 476,728 SNPs of Illumina DrugCore Gene chip and endurance athlete status was investigated in 796 European international-level athletes (645 males, 151 females) by comparing allelic frequencies between athletes specialized in sports with high ( = 662) and low/moderate ( = 134) aerobic component. Replication of results was performed by comparing the frequencies of the most significant SNPs between 242 and 168 elite Russian high and low/moderate aerobic athletes, respectively, and between 60 elite Japanese endurance athletes and 406 controls. A meta-analysis has identified rs1052373 (GG homozygotes) in Myosin Binding Protein (; implicated in cardiac hypertrophic myopathy) gene to be associated with endurance athlete status ( = 1.43 × 10, odd ratio 2.2). Homozygotes carriers of rs1052373 G allele in Russian athletes had significantly greater VO than carriers of the AA + AG ( = 0.005). Subsequent metabolomics analysis revealed several amino acids and lipids associated with rs1052373 G allele (1.82 × 10) including the testosterone precursor androstenediol (3beta,17beta) disulfate. This is the first report of genome-wide significant SNP and related metabolites associated with elite athlete status. Further investigations of the functional relevance of the identified SNPs and metabolites in relation to enhanced athletic performance are warranted
No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
There are strong genetic components to cardiorespiratory fitness and its
response to exercise training. It would be useful to understand the
differences in the genomic profile of highly trained endurance athletes of
world class caliber and sedentary controls. An international consortium
(GAMES) was established in order to compare elite endurance athletes and
ethnicity-matched controls in a case-control study design. Genome-wide
association studies were undertaken on two cohorts of elite endurance athletes
and controls (GENATHLETE and Japanese endurance runners), from which a panel
of 45 promising markers was identified. These markers were tested for
replication in seven additional cohorts of endurance athletes and controls:
from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is
based on a total of 1520 endurance athletes (835 who took part in endurance
events in World Championships and/or Olympic Games) and 2760 controls. We
hypothesized that world-class athletes are likely to be characterized by an
even higher concentration of endurance performance alleles and we performed
separate analyses on this subsample. The meta-analysis of all available
studies revealed one statistically significant marker (rs558129 at GALNTL6
locus, p = 0.0002), even after correcting for multiple testing. As shown by
the low heterogeneity index (I2 = 0), all eight cohorts showed the same
direction of association with rs558129, even though p-values varied across the
individual studies. In summary, this study did not identify a panel of genomic
variants common to these elite endurance athlete groups. Since GAMES was
underpowered to identify alleles with small effect sizes, some of the
suggestive leads identified should be explored in expanded comparisons of
world-class endurance athletes and sedentary controls and in tightly
controlled exercise training studies. Such studies have the potential to
illuminate the biology not only of world class endurance performance but also
of compromised cardiac functions and cardiometabolic diseases
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