Effective non-additive pair potential for lock-and-key interacting particles: the role of the limited valence

Theoretical studies of self-assembly processes and condensed phases in colloidal systems are often based on effective inter-particle potentials. Here we show that developing an effective potential for particles interacting with a limited number of ``lock-and-key'' selective bonds (due to the specificity of bio-molecular interactions) requires -- beside the non-sphericity of the potential -- a (many body) constraint that prevent multiple bonding on the same site. We show the importance of retaining both valence and bond-selectivity by developing, as a case study, a simple effective potential describing the interaction between colloidal particles coated by four single-strand DNA chains.Comment: 4 pages, 5 figure

Granular flow through an orifice: solving the free fall arch paradox

Several theoretical predictions of the mass flow rate of granular flows through outlets are based on the existence of a free fall arch region covering the silo outlet. Early in the nineteenth century, it was suggested that the particles crossing this region lose their kinetic energy and start to fall freely under their own weight. However, there is not conclusive evidence of this hypothetical region. We examined experimentally and numerically the micro-mechanical details of the particle flow through an orifice placed at the bottom of a silo. Remarkably, the contact stress monotonously decreases when the particles approach to the exit and it only vanishes just at the outlet. The behavior of this magnitude was practically independent of the size of orifice indicating that particle deformation, is insensible to the size of the aperture. Contrary, the behavior of the kinetic stress puts on evidence that the outlet size controls the propagation of the velocity fluctuations inside the silo. Examining this magnitude, we conclusively argue that indeed there is a well-defined transition region where the particle flow changes its nature. Above this region, the particle motion is completely correlated with the macroscopic flow. Our outcomes clarifies why the free fall arch picture has served as an approximation to describe the flow rate in the discharge of silos

A FRAMEWORK IN ONLINE LEARNING PROCESS: A GUIDE TO EDUCATIONAL TEACHING DURING COVID 19 PANDEMIC

Education is a continuous process of learning and it is a pinnacle of life attitude and a vision of every individual. It analyses the framework of online learning process and improvement guide during Covid 19 pandemic situation. It provides progress in work online learning process and level. The study aims to identify the different frameworks in online learning through implementation of teaching, delivery mode of teaching, support, and school system process as guide to educational system during Covid 19 pandemic. The study employs the application and benefit of Virtual Reality Design (VRD) because it possesses potential application in online learning process in education with systematic existence of design that displays the purpose of learning process and is considered as high-end design of research which is relevant to the study process. The study comprised Two Hundred Sixty Nine (269) from the professional lecturers and teachers in the different continents from Asia, Middle East, Africa, Australia, Europe, and United States of America. Random sampling technique is utilised in the study. Results of the study show an establish proper schedule of students in their regular classes during the period of Covid 19 pandemic and develop proper strategy in teaching during their lecture hours and provide focus to support students in their learning process and undertake initiatives despite of the limited resources in online teaching, identify the means of delivery mode of teaching based on the needs of students in their learning process, support students in their new modality of instruction in their online classes that boost their learning potential ability, and school provides guidelines for the online learning of student tools during Covid 19 pandemic to ensure better education.  Article visualizations

Dynamic model for energy predicting in WECS

This paper presents a dynamic simulation model of a wind generator, that allow to predict the quantity of removable energy in a specific place, using as initial condition wind measurements register in that place. The model is composed of four modules.The frist one is used to model de wind behaviour. The second is orientend to the aerodynamics model. The third is focused on the mechanical connection between the hub and the electrical machine. Finally, the fourth is dedicated to the electrical machine. The first model dedicated to the wind behaviour, includes an stochastic model. The aerodynamics conversion is base on the Strip Theory. The connection between the hub and the electrical machine used the mechanical differential equations. Finally, the electrical machine is modelled using the Power System Blockset including in Matlab Simulink

Anaplasmosis outbreak in lambs: First report causing carcass condemnation

In spring and summer 2020, six outbreaks of condemnation of jaundiced lamb carcasses were diagnosed in different farms in Aragón region, Spain. Anaplasma ovis was identified in all affected farms. Four hundred and ninety-two lambs from two affected farms were more closely examined. Clinical examination, haematologies, biochemistries, histopathology and microbiological and molecular analyses were performed. After slaughter, 34.84% of the lambs showed jaundiced carcasses and 79.64% presented splenomegaly at the abattoir. All tested lambs with icteric carcasses showed positive A. ovis PCR, although 72.72% of the unaffected lambs also tested positive. However, the bacterial load was significantly higher in the animals that showed jaundiced carcasses (Cq: 25.00 vs 26.16; p = 0.004). Moreover, all the tested lambs that showed severe anaemia were PCR positive. On the contrary, the PCR negative lambs did not show anaemia. Lambs that presented icteric carcasses displayed severe regenerative anaemia with significantly lower erythrocyte count (7.18 vs. 11.97), haematocrit (26.89 vs. 34.82) and haemoglobin (8.50 vs. 11.10) than unaffected lambs. Reticulocyte count (18.80 vs. 5.65) was also significantly increased in affected animals. This article describes a new disorder caused by Anaplasma ovis that is producing significant economic losses associated with the carcass condemnation of apparently healthy lamb

Self Consistent Molecular Field Theory for Packing in Classical Liquids

Building on a quasi-chemical formulation of solution theory, this paper proposes a self consistent molecular field theory for packing problems in classical liquids, and tests the theoretical predictions for the excess chemical potential of the hard sphere fluid. Results are given for the self consistent molecular fields obtained, and for the probabilities of occupancy of a molecular observation volume. For this system, the excess chemical potential predicted is as accurate as the most accurate prior theories, particularly the scaled particle (Percus-Yevick compressibility) theory. It is argued that the present approach is particularly simple, and should provide a basis for a molecular-scale description of more complex solutions.Comment: 6 pages and 5 figure

Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains

Objectives: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTHrelated protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal domain. Methods: We examined and compared the antioxidant capacity of PTHrP (1-37) with the C-terminal PTHrP domain comprising the 107-111 epitope (osteostatin) in both murine osteoblastic MC3T3-E1 cells and primary human osteoblastic cells. Results: We showed that both N- and C-terminal PTHrP peptides at 100 nM decreased reactive oxygen species production and forkhead box protein O activation following hydrogen peroxide (H 2 O 2 )-induced oxidation, which was related to decreased lipid oxidative damage and caspase-3 activation in these cells. This was associated with their ability to restore the deleterious effects of H 2 O 2 on cell growth and alkaline phosphatase activity, as well as on the expression of various osteoblast differentiation genes. The addition of Rp-cyclic 3',5'-hydrogen phosphorothioate adenosine triethylammonium salt (a cyclic 3',5'-adenosine monophosphate antagonist) and calphostin C (a protein kinase C inhibitor), or a PTH type 1 receptor antagonist, abrogated the effects of N-terminal PTHrP, whereas protein phosphatase 1 (an Src kinase activity inhibitor), SU1498 (a vascular endothelial growth factor receptor 2 inhibitor), or an anti osteostatin antiserum, inhibited the effects of C-terminal PTHrP. Conclusion: These findings indicate that the antioxidant properties of PTHrP act through its N- and C-terminal domains and provide novel insights into the osteogenic action of PTHrP.This work has been funded by grants from the Fundacion para la Investigacion Osea y Metabolismo Mineral-FEIOMM and the Instituto de Salud Carlos III (PI11/00449, PI15/00340, PI1600065, RD12/0043/0029, RD12/0043/0008 and RD12/0043/0018,). J. A. Ardua, D. Lozano, and S. Portal-Nunez are recipients of postdoctoral contracts from the Ministerio de Economia y Competitividad, Juan de la Cierva program JCI-2011-09548, FPDI-2013-17268, and RETICEF [FEDER “una manera de hacer Europa” (RD12/0043/0008)

MATH APPS UTILIZATION: ITS PERCEIVED EFFECTS TO THE ACADEMIC PERFORMANCE OF MATHEMATICS MAJOR STUDENTS

This study aimed to determine the perceived effects of apps utilization to study habits and academic performance. Further, it also sought to determine the views of the participants and respondents on their engagement in math apps and their relationship with study habits and academic performance. This study made use of explanatory-sequential design. The purposive sampling design was used to determine the respondents in quantitative data while the quota sampling design was also used to determine the participants in qualitative data. The study revealed that the mathematical application that is mostly used by the students is the calculator app as it garnered the highest percentage value of 80.85.%. The participants agreed that math applications serve as an aid for math problems, aid for lack of teaching by the teacher, promote learning of specific lessons and increase, and help in improving their academic performance. Respondents’ perception of their utilization of math apps is due to technical problems. The respondents also agreed that math application also affected their study habits in which they become dependent on it which led to laziness and tiredness. In addition, this study also found that there is a significant relationship between respondents’ utilization of math applications and their study habits. Lastly, there is also a significant relationship between the study habits and academic performance of selected math students of Notre Dame of Midsayap College.  Article visualizations

Differential associations of conduct disorder, callous‑unemotional traits and irritability with outcome expectations and values regarding the consequences of aggression

Background: Previous work has examined the association of aggression levels and callous-unemotional traits with outcome expectations and values regarding the consequences of aggression. Less work has examined the outcome expectations and values regarding the consequences of aggression of adolescents with Conduct Disorder (CD). Also, no studies have examined links between irritability (a second socio-affective trait associated with CD) and these social cognitive processes despite the core function of anger in retaliatory aggression and establishing dominance. Method: The current study, investigating these issues, involved 193 adolescents (typically developing [TD; N = 106], 87 cases with CD [N = 87]). Participants completed an adaptation of the Outcomes Expectations and Values Questionnaire and were assessed for CU traits and irritability via the Inventory of Callous-Unemotional traits and the Affective Reactivity Index. Results: While CD was associated with atypical outcome expectations this was not seen within statistical models including CU traits and irritability. CU traits were associated with decreased expectation that aggression would result in feelings of remorse and victim suffering, as well as decreased concern that aggressive acts would result in punishment and victim suffering. Irritability was associated with increased expectations and concern that aggression would result in dominance and forced respect. Conclusions: The results suggest that CU traits and irritability, often present in youth with CD, are associated with different forms of maladaptive outcome expectations and values regarding the consequences of aggression. This suggests that the atypical social cognitive processes underlying aggressive behavior among youth exhibiting CU traits may differ from those exhibiting problems regulating anger