Web Portal Design Guidelines as Identified by Children through the Processes of Design and Evaluation

The Web is an important source of information for school projects, but young users do not always find it easy to locate relevant material. A critical factor in success is the portal through which they search or browse web content. Traditionally web portals have been designed by adults with young users in mind, but there is very little evidence that the latter make use of them. In this paper design guidelines are elaborated for such portals that are based upon focus group and operational evaluations by elementary school students of two prototype web portals designed by two intergenerational teams, each comprising elementary school students and adult designers. The evaluations offer strong support for involving children throughout the design process for portals that both in presentation and functionality reflect the cognitive and affective needs of young users rather than adults

Supplementary material to "Replacement of GroEL in Escherichia coli by the group II chaperonin from the archaeon Methanococcus maripaludis"

Supplementary material to "Replacement of GroEL in Escherichia coli by the group II chaperonin from the archaeon Methanococcus maripaludis

Long-term peatland condition assessment via surface motion monitoring using the ISBAS DInSAR technique over the Flow Country, Scotland

Satellite Earth Observation (EO) is often used as a cost-effective method to report on the condition of remote and inaccessible peatland areas. Current EO techniques are primarily limited to reporting on the vegetation classes and properties of the immediate peat surface using optical data, which can be used to infer peatland condition. Another useful indicator of peatland condition is that of surface motion, which has the potential to report on mass accumulation and loss of peat. Interferometic SAR (InSAR) techniques can provide this using data from space. However, the most common InSAR techniques for information extraction, such as Persistent Scatterers’ Interferometry (PSI), have seen limited application over peat as they are primarily tuned to work in areas of high coherence (i.e., on hard, non-vegetated surfaces only). A new InSAR technique, called the Intermittent Small BAseline Subset (ISBAS) method, has been recently developed to provide measurements over vegetated areas from SAR data acquired by satellite sensors. This paper examines the feasibility of the ISBAS technique for monitoring long-term surface motion over peatland areas of the Flow Country, in the northeast of Scotland. In particular, the surface motions estimated are compared with ground data over a small forested area (namely the Bad a Cheo forest Reserve). Two sets of satellite SAR data are used: ERS C-band images, covering the period 1992–2000, and Sentinel-1 C-band images, covering the period 2015–2016. We show that the ISBAS measurements are able to identify surface motion over peatland areas, where subsidence is a consequence of known land cover/land use. In particular, the ISBAS products agree with the trend of surface motion, but there are uncertainties with their magnitude and direction (vertical). It is concluded that there is a potential for the ISBAS method to be able to report on trends in subsidence and uplift over peatland areas, and this paper suggests avenues for further investigation, but this requires a well-resourced validation campaign

Synchronizing Sequencing Software to a Live Drummer

Copyright 2013 Massachusetts Institute of Technology. MIT allows authors to archive published versions of their articles after an embargo period. The article is available at

Eddy-mediated transport of warm Circumpolar Deep Water across the Antarctic Shelf Break

The Antarctic Slope Front (ASF) modulates ventilation of the abyssal ocean via the export of dense Antarctic Bottom Water (AABW) and constrains shoreward transport of warm Circumpolar Deep Water (CDW) toward marine-terminating glaciers. Along certain stretches of the continental shelf, particularly where AABW is exported, density surfaces connect the shelf waters to the middepth Circumpolar Deep Water offshore, offering a pathway for mesoscale eddies to transport CDW directly onto the continental shelf. Using an eddy-resolving process model of the ASF, the authors show that mesoscale eddies can supply a dynamically significant transport of heat and mass across the continental shelf break. The shoreward transport of surface waters is purely wind driven, while the shoreward CDW transport is entirely due to mesoscale eddy transfer. The CDW flux is sensitive to all aspects of the model's surface forcing and geometry, suggesting that shoreward eddy heat transport may be localized to favorable sections of the continental slope

Improving spatial predictability of petroleum resources within the Central Tertiary Basin, Spitsbergen: a geochemical and petrographic study of coals from the eastern and western coalfields

Central Tertiary Basin (CTB) coals from a variety of palaeogeographic conditions within the Longyear and Verkhnij seams, were sampled to assess the relationship between the petroleum present, the remaining generation potential and coal geochemistry in order to improve the spatial predictability of petroleum resources within the basin. Vitrinite reflectance (VR) values from the CTB coals have been shown to be suppressed (Marshall et al., 2015a). This study attempts to quantify and correct for this suppression effect by applying the Lo (1993) method (LoVR), which uses Hydrogen Index (HI) values to modify VR data, and the coal Rank(Sr) scale of Suggate (2000, 2002), a technique not affected by suppression. In addition, the oil generation and expulsion thresholds for the CTB coals were investigated

Immunosuppression, eotaxin and the diagnostic changes in eosinophils that precede early acute heart allograft rejection.

Peripheral blood eosinophil counts (EOS) are undetectable in 40% blood samples sent for routine haematology at Papworth Hospital during the first 3 months after heart transplantation (HTx). Increases in EOS usually precede the development of allograft rejection by a median of 4 days. We compared the effects of cyclosporin (dose and total blood concentration), prednisolone (dose and both total and unbound plasma concentrations) and azathioprine, as well as plasma concentrations of the CCR-3 chemokines, eotaxin and RANTES, on changes in EOS in 47 consecutive HTx recipients, with a median follow-up of 90 (IQR 85-95) days. Multivariate analysis confirmed the independent association between both prednisolone dose (P<0.0001) and eotaxin (P<0.0001) and changes in EOS. The plasma eotaxin concentration was, in turn, most closely associated with the cyclosporin dose (P<0.001) and plasma prednisolone concentration (P=0.022). The blood cyclosporin concentration (P=0.028), EOS (P=0.012) and prednisolone dose (P=0.015) were all independently associated with the risk of treated acute rejection. When prednisolone pharmacokinetic parameters were substituted for the prednisolone dose in this multivariate model, only the pharmacokinetic parameter retained a significant association with the risk of rejection. Changes in EOS preceding cardiac allograft rejection are directly associated with plasma eotaxin concentrations and indirectly with prednisolone dosage. Cyclosporin may also indirectly influence these changes by inhibiting eotaxin production. EOS, prednisolone dose and blood cyclosporin concentrations were independently associated with the risk of acute rejection. The total and unbound fractions of prednisolone in plasma appear to be even more closely related to rejection but are difficult to measure. Monitoring EOS, as a surrogate measure of prednisolone immunosuppression, may be more cost-effective for controlling rejection than conventional cyclosporin monitoring in the first 6 weeks after HTx

All-sky Galactic radiation at 45 MHz and spectral index between 45 and 408 MHz

Aims: We study the Galactic large-scale synchrotron emission by generating a reliable all-sky spectral index map and temperature map at 45 MHz. Methods: We use our observations, the published all-sky map at 408 MHz, and a bibliographical compilation to produce a map corrected for zero-level offset and extragalactic contribution. Results: We present full sky maps of the Galactic emission at 45 MHz and the Galactic spectral index between 45 and 408 MHz with an angular resolution of 5\degs. The spectral index varies between 2.1 and 2.7, reaching values below 2.5 at low latitude because of thermal free-free absorption and its maximum in the zone next to the Northern Spur.Comment: A&A accepte

Archaea at St Andrews

A report of the Biochemical Society meeting 'The Molecular Biology of Archaea', St Andrews, UK, 19-21 August 2008