The effect of self-assessment on academic performance and the role of explicitness: a meta-analysis

It has been suggested for many years that students who are able to judge their own performance should do well in academic assessments. Despite the increasing number of empirical studies investigating the effect of self-assessment on academic performance, there has not been a recent synthesis of findings in the higher education context. The current meta-analysis aims to synthesise the effects of self-assessment on academic performance. In particular, it examines the difference between situations in which the process of self-assessment is revealed or observable (explicit) or not revealed or unobservable (implicit). A total of 98 effect sizes from 26 studies either reported a comparison between a group with self-assessment interventions and a control group (n = 20, k = 88) or a pre-post comparison (n = 6, k = 10). The overall effect of such interventions was significant (g = .455). Self-assessment interventions involving explicit feedback from others on students’ performance had a significantly larger effect size (g = .664) than those without explicit feedback (g = .213). There were no other significant moderators identified for either the overall effect or the effect of interventions involving explicit feedback

Interfacial friction in upward annular gas–liquid two-phase flow in pipes

Accurate prediction of interfacial friction between the gas and liquid in annular two-phase flow in pipes is essential for the proper modelling of pressure drop and heat transfer coefficient in pipeline systems. Many empirical relationships have been obtained over the last half century. However, they are restricted to limited superficial liquid and gas velocity ranges, essentially apply to atmospheric pressures, and the relationships are only relevant for pipes with inner diameters between 10 and 50 mm. In this study, we carried out experiments in a large diameter flow loop of 101.6 mm internal diameter with the superficial gas and liquid ranges of 11–29 m/s and 0.1–1.0 m/s respectively. An examination of published interfacial friction factor correlations was carried out using a diverse database which was collected from the open literature for vertical annular flow. The database includes measurements in pipes of 16–127 mm inner diameter for the liquid film thickness, interfacial shear stress, and pressure gradient for air-water, air-water/glycerol, and argon-water flows. Eleven studies are represented with experimental pressures of up to 6 bar. Significant discrepancies were found between many of the published correlations and the large pipe data, primarily in the thick film region at low interfacial shear stress. A correlation for the interfacial friction factor was hence derived using the extensive database. The correlation includes dimensionless numbers for the effect of the diameter across pipe scales to be better represented and better fit the wide range of experimental conditions, fluid properties, and operating pressures

Targeted online liquid chromatography electron capture dissociation mass spectrometry for the localization of sites of in vivo phosphorylation in human Sprouty2

We demonstrate a strategy employing collision-induced dissociation for phosphopeptide discovery, followed by targeted electron capture dissociation (ECD) for site localization. The high mass accuracy and low background noise of the ECD mass spectra allow facile sequencing of coeluting isobaric phosphopeptides, with up to two isobaric phosphopeptides sequenced from a single mass spectrum. In contrast to the previously described neutral loss of dependent ECD method, targeted ECD allows analysis of both phosphotyrosine peptides and lower abundance phosphopeptides. The approach was applied to phosphorylation analysis of human Sprouty2, a regulator of receptor tyrosine kinase signaling. Fifteen sites of phosphorylation were identified, 11 of which are novel

Facile mechanochemical synthesis of non-stoichiometric silica-carbon composite for enhanced lithium storage properties

A large number of new electrode materials and novel structural designs are emerging for lithium-ion batteries, yet scalable synthesis and raw material costs still hinder the practical application of such materials. Here, we designed and fabricated a low-cost SiOx/C composite by a facile and scalable mechanofusion route with a ball-milling method. We selected aerosil and graphite precursor-needle coke, which are two widely used materials in industry, as a silicon source and carbon source, respectively. This SiOx/C composite shows a high reversible capacity (ca. 550 mAh g−1) at the 180th cycle and good rate performance. Our scalable synthesis route of electrode materials can stimulate the progress of other energy storage technologies for practical applications

Essential and checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1

A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases. During meiosis, Tel1 and Mec1, the budding yeast ATM and ATR, respectively, rely on a meiotic adaptor protein Hop1, a 53BP1/Rad9 functional analog, and its associated kinase Mek1, a CHK2/Rad53-paralog, to mediate multiple functions: control of the formation and repair of programmed meiotic DNA double strand breaks, enforcement of inter-homolog bias, regulation of meiotic progression, and implementation of checkpoint responses. Here, we present evidence that the multi-functionality of the Tel1/Mec1-to-Hop1/Mek1 signalling depends on stepwise activation of Mek1 that is mediated by Tel1/Mec1 phosphorylation of two specific residues within Hop1: phosphorylation at the threonine 318 (T318) ensures the transient basal level Mek1 activation required for viable spore formation during unperturbed meiosis. Phosphorylation at the serine 298 (S298) promotes stable Hop1-Mek1 interaction on chromosomes following the initial phospho-T318 mediated Mek1 recruitment. In the absence of Dmc1, the phospho-S298 also promotes Mek1 hyper-activation necessary for implementing meiotic checkpoint arrest. Taking these observations together, we propose that the Hop1 phospho-T318 and phospho-S298 constitute key components of the Tel1/Mec1- based meiotic recombination surveillance (MRS) network and facilitate effective coupling of meiotic recombination and progression during both unperturbed and challenged meiosis

Budget Processes: Theory and Experimental Evidence

This paper studies budget processes, both theoretically and experimentally. We compare the outcomes of bottom-up and top-down budget processes. It is often presumed that a top-down budget process leads to a smaller overall budget than a bottom-up budget process. Ferejohn and Krehbiel (1987) showed theoretically that this need not be the case. We test experimentally the theoretical predictions of their work. The evidence from these experiments lends strong support to their theory, both at the aggregate and the individual subject level

Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints that can lead to deformities and disability. The prolonged use of conventionally used drugs is associated with severe adverse reactions. Therefore, safer and less expensive therapeutic products are continually being sought. Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity. In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic inflammation and tissue damage, namely, chemokines and matrix-metalloproteinases (MMPs) in the rat adjuvant-induced arthritis (AA) model of RA. We treated arthritic Lewis rats with HLXL (2.3 g/kg) by daily gavage beginning at the onset of AA. The control rats received the vehicle. At the peak phase of AA, rats were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested. The HLXL-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1α, and GRO/KC), MMPs (MMP 2 and 9), as well as cytokines (IL-6 and IL-17) that induce them, compared to the control vehicle-treated rats. Thus, HLXL controls arthritis in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for RA