Juvenile fibroadenoma arising in ectopic breast tissue presenting as an axillary mass

AbstractThe differential diagnosis of an axillary mass during childhood is extensive and malignant processes such as lymphoma or metastatic disease must be excluded. We describe an unusual case of a fibroadenoma growing within ectopic breast tissue located in the axilla in a 10 year old girl. The mass grew rapidly and was removed during an excisional biopsy. Histological evaluation revealed a diagnosis of fibroadenoma. Fibroadenoma of ectopic breast tissue has not previously been reported in the pediatric age group, and must be considered as part of the differential diagnosis for pediatric axillary masses

Thermal Timescale Mass Transfer and the Evolution of White Dwarf Binaries

The evolution of binaries consisting of evolved main sequence stars (1 < M_d/Msun < 3.5) with white dwarf companions (0.7 < M_wd/Msun < 1.2) is investigated through the thermal mass transfer phase. Taking into account the stabilizing effect of a strong, optically thick wind from the accreting white dwarf surface, we have explored the formation of several evolutionary groups of systems for progenitors with initial orbital periods of 1 and 2 days. The numerical results show that CO white dwarfs can accrete sufficient mass to evolve to a Type Ia supernova and ONeMg white dwarfs can be built up to undergo accretion induced collapse for donors more massive than about 2 Msun. For donors less massive than ~2 Msun the system can evolve to form a He and CO or ONeMg white dwarf pair. In addition, sufficient helium can be accumulated (~0.1 Msun) in systems characterized by 1.6 < M_d/Msun < 1.9 and 0.8 < M_wd/Msun < 1 such that sub Chandrasekhar mass models for Type Ia supernovae, involving off center helium ignition, are possible for progenitor systems evolving via the Case A mass transfer phase. For systems characterized by mass ratios > 3 the system likely merges as a result of the occurrence of a delayed dynamical mass transfer instability. A semi-analytical model is developed to delineate these phases which can be easily incorporated in population synthesis studies of these systems.Comment: 9 pages, 6 figures, Latex, emulateapj style, ApJ accepte

Investigating the delivery of health and nutrition interventions for women and children in conflict settings: a collection of case studies from the BRANCH Consortium.

Globally, the number of people affected by conflict is the highest in history, and continues to steadily increase. There is currently a pressing need to better understand how to deliver critical health interventions to women and children affected by conflict. The compendium of articles presented in this Conflict and Health Collection brings together a range of case studies recently undertaken by the BRANCH Consortium (Bridging Research & Action in Conflict Settings for the Health of Women and Children). These case studies describe how humanitarian actors navigate and negotiate the multiple obstacles and forces that challenge the delivery of health and nutrition interventions for women, children and adolescents in conflict-affected settings, and to ultimately provide some insight into how service delivery can be improved

Anisotropic Panglial Coupling Reflects Tonotopic Organization in the Inferior Colliculus

Astrocytes and oligodendrocytes in different brain regions form panglial networks and the topography of such networks can correlate with neuronal topography and function. Astrocyte-oligodendrocyte networks in the lateral superior olive (LSO)—an auditory brainstem nucleus—were found to be anisotropic with a preferred orientation orthogonally to the tonotopic axis. We hypothesized that such a specialization might be present in other tonotopically organized brainstem nuclei, too. Thus, we analyzed gap junctional coupling in the center of the inferior colliculus (IC)—another nucleus of the auditory brainstem that exhibits tonotopic organization. In acute brainstem slices obtained from mice, IC networks were traced employing whole-cell patch-clamp recordings of single sulforhodamine (SR) 101-identified astrocytes and concomitant intracellular loading of the gap junction-permeable tracer neurobiotin. The majority of dye-coupled networks exhibited an oval topography, which was preferentially oriented orthogonal to the tonotopic axis. Astrocyte processes showed preferentially the same orientation indicating a correlation between astrocyte and network topography. In addition to SR101-positive astrocytes, IC networks contained oligodendrocytes. Using Na+ imaging, we analyzed the capability of IC networks to redistribute small ions. Na+ bi-directionally diffused between SR101-positive astrocytes and SR101-negative cells—presumably oligodendrocytes—showing the functionality of IC networks. Taken together, our results demonstrate that IC astrocytes and IC oligodendrocytes form functional anisotropic panglial networks that are preferentially oriented orthogonal to the tonotopic axis. Thus, our data indicate that the topographic specialization of glial networks seen in IC and LSO might be a general feature of tonotopically organized auditory brainstem nuclei

Quality of Life 10 Years after Sleeve Gastrectomy: A Multicenter Study

Objective: Sleeve gastrectomy (SG) has recently become the most commonly applied bariatric procedure worldwide. Substantial regaining of weight or severe reflux might compromise quality of life (QOL) after SG in the long-term follow-up. Long-term data on patients’ QOL is limited, even though the persistent improvement in QOL is one of the aims of bariatric surgery. The objective of this study was to present patients’ QOL 10 years after SG. Methods: Of 65 SG patients with a follow-up of ≥10 years after SG who were asked to fill out the Bariatric Quality of Life Index (BQL) and Short Form 36 (SF36) questionnaires, 48 (74%) completed them. This multicenter study was performed in a university hospital setting in Austria. Results: The BQL score revealed nonsignificant differences between the patients with &#x3e; 50% or &#x3c; 50% excess weight loss (EWL). It did show significant differences between patients with and without any symptoms of reflux. Patients with &#x3c; 50% EWL scored significantly lower in 3/8 categories of SF36. Patients suffering from reflux had significantly lower scores in all categories. Conclusions: EWL and symptomatic reflux impair patients’ long-term QOL after SG

Information practices for sustainability: role of iSchools in achieving the UN sustainable development goals(SDGs)

In September 2015, the United Nations (UN) GeneralAssembly passed a resolution identifying 17 Sustain-able Development Goals (SDGs) and 169 associated tar-gets, and countries around the world agreed to achievethese by 2030. By conducting a thematic analysis offour key UN policy documents related to sustainabledevelopment, this paper argues that alongside financialand other resources, access to, and use of, appropriateinformation are essential for achieving SDGs. The paperalso reviews research on information and sustainabilityundertaken at the iSchools and the computer andhuman–computer interaction HCI communities. Giventhat the mission of iSchools is to connect people andsociety with the required information through the use ofappropriate technologies and tools, this paper arguesthat iSchools can play a key role in helping people, insti-tutions, and businesses, and thus countries around theworld achieve SDGs. The paper identifies 4 broad areasof teaching and research that can help iSchools aroundthe world prepare a trained workforce who can manage,and facilitate access to, information in specific domainsand contexts. It is also argued that cooperation and col-laborations among iSchools can promote a culture ofsustainable information practices among universitygraduates and researchers in different disciplines thatwill pave the way for achieving SDGs in every sector

Leading Interview and Interrogation Techniques. Focus on Cognitive Interview

Criminal investigation in Mexico is performed by the investigation triad, which is made up of police and experts in diff erent areas such as medicine and prosecutors. They all use interview and interrogation techniques to do their work. Unfortunately, in Mexico, there is no culture of training in governmental institutions responsible for investigating crimes, and results in ignorance of techniques for obtaining objective and reliable information that guarantees the protection of fundamental rights. This chapter illustrates the scope and limits of interview and interrogation techniques and their objectives, with emphasis on the cognitive interview (CI). Th e CI, which has been validated scientifi cally, is one of the best tools to obtain useful information, that is, results of a CI that have been conducted in the field can be used in a court of law. Th is technique can be used with victims, witnesses, or suspects. The current chapter also describes the most utilized techniques, cognitive interview, mnemonic techniques, Strategic Use of Evidence, and Verifi ability Approach

Educational Attainment Moderates the Association Between Hippocampal Volumes and Memory Performances in Healthy Older Adults

Objective: To examine whether educational attainment, as a proxy of cognitive reserve, moderated the association between hippocampal volumes and episodic verbal memory performances in healthy older adults.Methods: Data from 76 community dwelling older adults were included in the present study. Measures of hippocampal volumes (total, left, and right) were obtained using FreeSurfer software. Immediate and delayed verbal recall scores were derived from performances on the California Verbal Learning Test-Second Edition and the Wechsler Memory Scale- Third Edition. Educational attainment was defined by years of education. Linear regression analyses were performed using immediate and delayed recall as dependent variables and hippocampal volumes, years of education, and their interaction terms as independent variables. All analyses were controlled for age, sex, depression, and health status.Results: Total and left Hippocampal volumes had a positive main effect on delayed recall only. Additionally, the interaction between total, left, and right hippocampal volumes and education was a significant predictor for delayed recall performance but not for immediate recall performance. The positive association between hippocampal volumes and delayed recall was greatest in those with more years of education.Conclusion: Larger hippocampal volumes were associated with better delayed verbal recall and the effect on delayed recall was greatest in those with more years of education. Having higher levels of education, or cognitive reserve, may enable individuals to capitalize on greater structural integrity in the hippocampus to support delayed recall in old age. However, longitudinal research is needed to investigate the directionality of these associations