839 research outputs found
Hypnotics' association with mortality or cancer: a matched cohort study
Objectives: An estimated 6%e10 % of US adults took a hypnotic drug for poor sleep in 2010. This study extends previous reports associating hypnotics with excess mortality. Setting: A large integrated health system in the USA. Design: Longitudinal electronic medical records were extracted for a one-to-two matched cohort survival analysis. Subjects: Subjects (mean age 54 years) were 10 529 patients who received hypnotic prescriptions and 23 676 matched controls with no hypnotic prescriptions, followed for an average of 2.5 year
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Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer
Quantified duplex augmentation in healthy subjects and patients with venous disease: San Diego population study
AbstractObjective: This study was undertaken to determine the quantitative augmentation response in several veins examined in a cohort assembled to permit comparisons by sex, age, and ethnicity, under normal conditions and in the presence of obstruction, with and without trophic changes. Method: The common femoral vein, superficial femoral vein, sapheno-femoral junction, popliteal vein, sapheno-popliteal junction, and posterior tibial vein were studied with duplex ultrasonographic scanning. Augmentation response was elicited with use of an automated cuff inflator. Mean level of each response was analyzed according to patient sex, age, and ethnicity, each adjusted for the other two. Normal values were compared with those obtained from legs with venous obstructive disease, with or without signs of trophic changes. Results: Decreased augmentation response was noted only in the sapheno-femoral junction and sapheno-popliteal junction, and was smaller in women. Augmentation response was slightly increased in the oldest age group (>70 years) in the common femoral vein, superficial femoral vein, popliteal vein, and posterior tibial vein. The highest augmentation response was found in Asian subjects, in the common and superficial femoral veins and the sapheno-femoral and sapheno-popliteal junctions; and the smallest augmentation response was found in African American subjects, in these same veins and junctions. Differences in vein diameters may explain these findings, ie, smaller diameters in Asians and larger diameters in African Americans. Most important, compared with normal values, augmentation response was decreased in legs with venous obstructive disease only when trophic changes were present. Conclusion: Like quantification of reflux, quantitative evaluation of the augmentation response may help in diagnosis of venous obstructive disease when trophic changes are present. (J Vasc Surg 2003;37:1054-8.
Scattering theory for Klein-Gordon equations with non-positive energy
We study the scattering theory for charged Klein-Gordon equations:
\{{array}{l} (\p_{t}- \i v(x))^{2}\phi(t,x) \epsilon^{2}(x,
D_{x})\phi(t,x)=0,[2mm] \phi(0, x)= f_{0}, [2mm] \i^{-1} \p_{t}\phi(0, x)=
f_{1}, {array}. where: \epsilon^{2}(x, D_{x})= \sum_{1\leq j, k\leq
n}(\p_{x_{j}} \i b_{j}(x))A^{jk}(x)(\p_{x_{k}} \i b_{k}(x))+ m^{2}(x),
describing a Klein-Gordon field minimally coupled to an external
electromagnetic field described by the electric potential and magnetic
potential . The flow of the Klein-Gordon equation preserves the
energy: h[f, f]:= \int_{\rr^{n}}\bar{f}_{1}(x) f_{1}(x)+
\bar{f}_{0}(x)\epsilon^{2}(x, D_{x})f_{0}(x) - \bar{f}_{0}(x) v^{2}(x) f_{0}(x)
\d x. We consider the situation when the energy is not positive. In this
case the flow cannot be written as a unitary group on a Hilbert space, and the
Klein-Gordon equation may have complex eigenfrequencies. Using the theory of
definitizable operators on Krein spaces and time-dependent methods, we prove
the existence and completeness of wave operators, both in the short- and
long-range cases. The range of the wave operators are characterized in terms of
the spectral theory of the generator, as in the usual Hilbert space case
Impact of cyclooxygenase inhibitors in the Women's Health Initiative hormone trials: secondary analysis of a randomized trial.
OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials. Estrogen increases COX expression, and inhibitors of COX such as nonsteroidal anti-inflammatory agents appear to increase coronary risk, raising the possibility of a clinically important interaction in the trials. DESIGN: The hormone trials were randomized, double-blind, and placebo-controlled. Use of nonsteroidal anti-inflammatory drugs was assessed at baseline and at years 1, 3, and 6. SETTING: The Women's Health Initiative hormone trials were conducted at 40 clinical sites in the United States. PARTICIPANTS: The trials enrolled 27,347 postmenopausal women, aged 50-79 y. INTERVENTIONS: We randomized 16,608 women with intact uterus to conjugated estrogens 0.625 mg with medroxyprogesterone acetate 2.5 mg daily or to placebo, and 10,739 women with prior hysterectomy to conjugated estrogens 0.625 mg daily or placebo. OUTCOME MEASURES: Myocardial infarction, coronary death, and coronary revascularization were ascertained during 5.6 y of follow-up in the estrogen plus progestin trial and 6.8 y of follow-up in the estrogen alone trial. RESULTS: Hazard ratios with 95% confidence intervals were calculated from Cox proportional hazard models stratified by COX inhibitor use. The hazard ratio for myocardial infarction/coronary death with estrogen plus progestin was 1.13 (95% confidence interval 0.68-1.89) among non-users of COX inhibitors, and 1.35 (95% confidence interval 0.86-2.10) among continuous users. The hazard ratio with estrogen alone was 0.92 (95% confidence interval 0.57-1.48) among non-users of COX inhibitors, and 1.08 (95% confidence interval 0.69-1.70) among continuous users. In a second analytic approach, hazard ratios were calculated from Cox models that included hormone trial assignment as well as a time-dependent covariate for medication use, and an interaction term. No significant interaction was identified. CONCLUSIONS: Use of COX inhibitors did not significantly affect the Women's Health Initiative hormone trial results
Starburst99: Synthesis Models for Galaxies with Active Star Formation
Starburst99 is a comprehensive set of model predictions for
spectrophotometric and related properties of galaxies with active star
formation. The models are an improved and extended version of the data set
previously published by Leitherer & Heckman (1995). We have upgraded our code
by implementing the latest set of stellar evolution models of the Geneva group
and the model atmosphere grid compiled by Lejeune et al. (1997). Several
predictions which were not included in the previous publication are shown here
for the first time. The models are presented in a homogeneous way for five
metallicities between Z = 0.040 and 0.001 and three choices of the initial mass
function. The age coverage is 10^6 to 10^9 yr. We also show the spectral energy
distributions which are used to compute colors and other quantities. The full
data set is available for retrieval at
http://www.stsci.edu/science/starburst99/. This website allows users to run
specific models with non-standard parameters as well. We also make the source
code available to the community.Comment: 32 pages, LaTeX. All the Figures and the summary Table are located at
http://www.stsci.edu/science/starburst99/, ApJ accepte
Polar Smectic Films
We report on a new experimental procedure for forming and studying polar
smectic liquid crystal films. A free standing smectic film is put in contact
with a liquid drop, so that the film has one liquid crystal/liquid interface
and one liquid crystal/air interface. This polar environment results in changes
in the textures observed in the film, including a boojum texture and a
previously unobserved spiral texture in which the winding direction of the
spiral reverses at a finite radius from its center. Some aspects of these
textures are explained by the presence of a Ksb term in the bulk elastic free
energy density that favors a combination of splay and bend deformations.Comment: 4 pages, REVTeX, 3 figures, submitted to PR
Episodic mass loss in binary evolution to the Wolf-Rayet phase: Keck and HST proper motions of RY Scuti's nebula
Binary mass transfer via Roche-lobe overflow (RLOF) is a key channel for
producing stripped-envelope Wolf-Rayet (WR) stars and may be critical to
account for SN Ib/c progenitors. RY Scuti is an extremely rare example of a
massive binary star caught in this brief but important phase. Its toroidal
nebula indicates equatorial mass loss during RLOF, while the mass-gaining star
is apparently embedded in an opaque accretion disk. RY Scuti's toroidal nebula
has two components: an inner ionised double-ring system, and an outer dust
torus that is twice the size of the ionised rings. We present two epochs of
Lband Keck NGS-AO images of the dust torus, plus three epochs of HST images of
the ionised gas rings. Proper motions show that the inner ionised rings and the
outer dust torus came from two separate ejection events roughly 130 and 250 yr
ago. This suggests that RLOF in massive contact binaries can be accompanied by
eruptive and episodic burst of mass loss, reminiscent of LBVs. We speculate
that the repeating outbursts may arise in the mass gainer from instabilities
associated with a high accretion rate. If discrete mass-loss episodes in other
RLOF binaries are accompanied by luminous outbursts, they might contribute to
the population of extragalactic optical transients. When RLOF ends for RY
Scuti, the overluminous mass gainer, currently surrounded by an accretion disk,
will probably become a B[e] supergiant and may outshine the hotter mass-donor
star that should die as a Type Ib/c supernova.Comment: 15 pages, 7 figures, submitted to MNRA
Novel pulsatile-release microparticles for single-injection vaccination
Many controlled release devices are designed to achieve near zero-order release kinetics, however for some applications, such as vaccination, non-continuous or pulsatile release is desired. Such pulsatile release systems may enable the creation of single-injection vaccines that eliminate the need for subsequent booster immunizations by spontaneously releasing antigen at time points that correspond to normal vaccination regimens. This would be especially important in the developing world where a lack of consistent access to healthcare contributes to approximately 1.5 million vaccine-preventable deaths each year.1 Here we present the fabrication and characterization of biodegradable core-shell microparticles that exhibit pulsatile release kinetics due to their unique structure. These particles are produced using a novel fabrication process that combines soft lithography, picoliter dispensing, optical alignment, and a gentle heat-based sintering step to generate microparticles with a biodegradable polymeric shell surrounding an antigen-filled core. By altering the composition (e.g. copolymer ratio or molecular weight) of the poly(lactic-co-glycolic acid) shell, particles can be tuned to release discrete pulses of a model antigen at times ranging from four days to two months. This fabrication method is also compatible with sensitive biologics, such as the inactivated polio virus, which retains \u3e80% of its antigenicity after encapsulation. Further, because the shell of the particle is physically separated from the core, these particles can be filled with any aqueous vaccine solution without affecting release kinetics and be easily scaled via massively parallel fabrication. As a result, these particles have exciting potential as single-injection vaccines that fully mimic the antigen presentation profile of traditional bolus injections administered over the course of months or years.
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Nanowired three-dimensional cardiac patches
Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds1, 2, 3. These biomaterials, which are usually made of either biological polymers such as alginate4 or synthetic polymers such as poly(lactic acid) (PLA)5, help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit6. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.National Institutes of Health (U.S.) (NIH, grant GM073626)National Institutes of Health (U.S.) (NIH, grant DE13023)National Institutes of Health (U.S.) (NIH, grant DE016516)American Heart Association (Postdoctoral Fellowship)National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award (no. F32GM096546)
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