Observed crustal uplift near the Southern Patagonian Icefield constrains improved viscoelastic Earth model

Thirty‒one GPS geodetic measurements of crustal uplift in southernmost South America determined extraordinarily high trend rates (> 35 mm/yr) in the north‒central part of the Southern Patagonian Icefield. These trends have a coherent pattern, motivating a refined viscoelastic glacial isostatic adjustment model to explain the observations. Two end‒member models provide good fits: both require a lithospheric thickness of 36.5 ± 5.3 km. However, one end‒member has a mantle viscosity near η =1.6 ×1018 Pa s and an ice collapse rate from the Little Ice Age (LIA) maximum comparable to a lowest recent estimate of 1995–2012 ice loss at about −11 Gt/yr. In contrast, the other end‒member has much larger viscosity: η = 8.0 ×1018 Pa s, half the post–LIA collapse rate, and a steadily rising loss rate in the twentieth century after AD 1943, reaching −25.9 Gt/yr during 1995–2012.Fil: Lange, H.. Technische Universitaet Dresden; AlemaniaFil: Casassa, G.. Centro de Estudios Cientificos; Chile. Universidad de Magallanes; ChileFil: Ivins, E. R.. Institute of Technology. Jet propulsion Laboratory; Estados UnidosFil: Schroeder, L.. Technische Universitaet Dresden; AlemaniaFil: Fritsche, M.. Technische Universitaet Dresden; AlemaniaFil: Richter, Andreas Jorg. Technische Universitaet Dresden; Alemania. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas. Departamento de Astrometría; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Groh, A.. Technische Universitaet Dresden; AlemaniaFil: Dietrich, R.. Technische Universitaet Dresden; Alemani

The application of eye-tracking in music research

Though eye-tracking is typically a methodology applied in the visual research domain, recent studies suggest its relevance in the context of music research. There exists a community of researchers interested in this kind of research from varied disciplinary backgrounds scattered across the globe. Therefore, in August 2017, an international conference was held at the Max Planck Institute for Empirical Aesthetics in Frankfurt, Germany, to bring this research community together. The conference was dedicated to the topic of music and eye-tracking, asking the question: what do eye movements, pupil dilation, and blinking activity tell us about musical processing? This special issue is constituted of top-scoring research from the conference and spans a range of music-related topics. From tracking the gaze of performers in musical trios to basic research on how eye movements are affected by background music, the contents of this special issue highlight a variety of experimental approaches and possible applications of eye-tracking in music research

Markov Chain Beam Randomization: a study of the impact of PLANCK beam measurement errors on cosmological parameter estimation

We introduce a new method to propagate uncertainties in the beam shapes used to measure the cosmic microwave background to cosmological parameters determined from those measurements. The method, which we call Markov Chain Beam Randomization, MCBR, randomly samples from a set of templates or functions that describe the beam uncertainties. The method is much faster than direct numerical integration over systematic `nuisance' parameters, and is not restricted to simple, idealized cases as is analytic marginalization. It does not assume the data are normally distributed, and does not require Gaussian priors on the specific systematic uncertainties. We show that MCBR properly accounts for and provides the marginalized errors of the parameters. The method can be generalized and used to propagate any systematic uncertainties for which a set of templates is available. We apply the method to the Planck satellite, and consider future experiments. Beam measurement errors should have a small effect on cosmological parameters as long as the beam fitting is performed after removal of 1/f noise.Comment: 17 pages, 23 figures, revised version with improved explanation of the MCBR and overall wording. Accepted for publication in Astronomy and Astrophysics (to appear in the Planck pre-launch special issue

Reversing quantum trajectories with analog feedback

We demonstrate the active suppression of transmon qubit dephasing induced by dispersive measurement, using parametric amplification and analog feedback. By real-time processing of the homodyne record, the feedback controller reverts the stochastic quantum phase kick imparted by the measurement on the qubit. The feedback operation matches a model of quantum trajectories with measurement efficiency $\tilde{\eta} \approx 0.5$, consistent with the result obtained by postselection. We overcome the bandwidth limitations of the amplification chain by numerically optimizing the signal processing in the feedback loop and provide a theoretical model explaining the optimization result.Comment: 5 pages, 4 figures, and Supplementary Information (7 figures

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease

There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients. The mechanisms by which NSAIDs exert these effect are unclear. In a prospective, controlled clinical trial we examined the effects of oral indomethacin on the composition of human gall-bladder bile. The study included 28 patients with symptomatic cholesterol or mixed gallstones. Of these, 8 were treated with 3 × 25 mg indomethacin daily for 7 days prior to elective cholecystectomy while 20 received no treatment and served as controls. Bile and tissue samples from the gallbladder were obtained during cholecystectomy. Indomethacin tissue levels in the gallbladder mucosa, as assessed by HPLC, were 1.05±0.4 ng/mg wet weight, a concentration known to inhibit effectively cyclooxygenase activity. Nevertheless, no differences between the treated and untreated groups were found in the concentrations of biliary mucus glycoprotein (0.94±0.27 versus 0.93±0.32 mg/ml) or total protein (5.8±0.9 versus 6.4±1.3 mg/ml), cholesterol saturation (1.3±0.2 versus 1.5±0.2), or nucleation time (2.0±3.0 versus 1.5±2.0 days). However, biliary viscosity, measured using a low-shear rotation viscosimeter, was significantly lower in patients receiving indomethacin treatment (2.9±0.6 versus 5.6±1.2 mPa.s; P < 0.02). In conclusion, in man oral indomethacin decreases bile viscosity without alteration of bile lithogenicity or biliary mucus glycoprotein content. Since mucus glycoproteins are major determinants of bile viscosity, an alteration in mucin macromolecular composition may conceivably cause the indomethacin-induced decrease in biliary viscosity and explain the beneficial effects of nonsteroidal anti-inflammatory drugs in gallstone disease

Evaluation of metallic positive expulsion bellows operating parameters with cryogenic propellants

Environmental tests of cryogenic propellant effects on metallic positive expulsion bellows operating parameter