438 research outputs found
Experiments on the fragmentation of a buoyant liquid volume in another liquid
We present experiments on the instability and fragmentation of volumes of
heavier liquid released into lighter immiscible liquids. We focus on the regime
defined by small Ohnesorge numbers, density ratios of order one, and variable
Weber numbers. The observed stages in the fragmentation process include
deformation of the released fluid by either Rayleigh-Taylor instability or
vortex ring roll-up and destabilization, formation of filamentary structures,
capillary instability, and drop formation. At low and intermediate Weber
numbers, a wide variety of fragmentation regimes is identified. Those regimes
depend on early deformations, which mainly result from a competition between
the growth of Rayleigh-Taylor instabilities and the roll-up of a vortex ring.
At high Weber numbers, turbulent vortex ring formation is observed. We have
adapted the standard theory of turbulent entrainment to buoyant vortex rings
with initial momentum. We find consistency between this theory and our
experiments, indicating that the concept of turbulent entrainment is valid for
non-dispersed immiscible fluids at large Weber and Reynolds numbers
Toughening and asymmetry in peeling of heterogeneous adhesives
The effective adhesive properties of heterogeneous thin films are
characterized through a combined experimental and theoretical investigation. By
bridging scales, we show how variations of elastic or adhesive properties at
the microscale can significantly affect the effective peeling behavior of the
adhesive at the macroscale. Our study reveals three elementary mechanisms in
heterogeneous systems involving front propagation: (i) patterning the elastic
bending stiffness of the film produces fluctuations of the driving force
resulting in dramatically enhanced resistance to peeling; (ii) optimized
arrangements of pinning sites with large adhesion energy are shown to control
the effective system resistance, allowing the design of highly anisotropic and
asymmetric adhesives; (iii) heterogeneities of both types result in front
motion instabilities producing sudden energy releases that increase the overall
adhesion energy. These findings open potentially new avenues for the design of
thin films with improved adhesion properties, and motivate new investigation of
other phenomena involving front propagation.Comment: Physical Review Letters (2012)
Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging
peer reviewedThere is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve, which designates the partial protection from the deleterious effects of aging that lifetime experience provides. Neuroimaging studies examining task-related activation in elderly people suggested that cognitive reserve takes the form of more efficient use of brain networks and/or greater ability to recruit alternative networks to compensate for age-related cerebral changes. In this multi-centre study, we examined the relationships between cognitive reserve, as measured by education and verbal intelligence, and cerebral metabolism at rest (FDG-PET) in a sample of 74 healthy older participants. Higher degree of education and verbal intelligence was associated with less metabolic activity in the right posterior temporoparietal cortex and the left anterior intraparietal sulcus. Functional connectivity analyses of resting-state fMRI images in a subset of 41 participants indicated that these regions belong to the default mode network and the dorsal attention network respectively. Lower metabolism in the temporoparietal cortex was also associated with better memory abilities. The findings provide evidence for an inverse relationship between cognitive reserve and resting-state activity in key regions of two functional networks respectively involved in internal mentation and goal-directed attention
Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease.
International audienceA sensitive marker for monitoring progression of early Alzheimer's disease would help to develop and test new therapeutic strategies. The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients with amnestic mild cognitive impairment, according to their clinical outcome (converters or non-converters), and in relation to their cognitive decline. Seventeen amnestic mild cognitive impairment patients underwent magnetic resonance imaging and 18FDG-positron emission tomography scans both at inclusion and 18 months later. Baseline and follow-up positron emission tomography data were corrected for partial volume effects and spatially normalized using magnetic resonance imaging data, scaled to the vermis and compared using SPM2. 'PET-PAC' maps reflecting metabolic per cent annual changes were created for correlation analyses with cognitive decline. In the whole sample, the greatest metabolic decrease concerned the posterior cingulate-precuneus area. Converters had significantly greater metabolic decrease than non-converters in two ventro-medial prefrontal areas, the subgenual (BA25) and anterior cingulate (BA24/32). PET-PAC in BA25 and BA24/32 combined allowed complete between-group discrimination. BA25 PET-PAC significantly correlated with both cognitive decline and PET-PAC in the hippocampal region and temporal pole, while BA24/32 PET-PAC correlated with posterior cingulate PET-PAC. Finally, the metabolic change in BA8/9/10 was inversely related to that in BA25 and showed relative increase with cognitive decline, suggesting that compensatory processes may occur in this dorso-medial prefrontal region. The observed ventro-medial prefrontal disruption is likely to reflect disconnection from the hippocampus, both indirectly through the cingulum bundle and posterior cingulate cortex for BA24/32, and directly through the uncinate fasciculus for BA25. Altogether, our findings emphasize the potential of 18FDG-positron emission tomography for monitoring early Alzheimer's disease progression
Mechanisms and Geochemical Models of Core Formation
The formation of the Earth's core is a consequence of planetary accretion and
processes in the Earth's interior. The mechanical process of planetary
differentiation is likely to occur in large, if not global, magma oceans
created by the collisions of planetary embryos. Metal-silicate segregation in
magma oceans occurs rapidly and efficiently unlike grain scale percolation
according to laboratory experiments and calculations. Geochemical models of the
core formation process as planetary accretion proceeds are becoming
increasingly realistic. Single stage and continuous core formation models have
evolved into multi-stage models that are couple to the output of dynamical
models of the giant impact phase of planet formation. The models that are most
successful in matching the chemical composition of the Earth's mantle, based on
experimentally-derived element partition coefficients, show that the
temperature and pressure of metal-silicate equilibration must increase as a
function of time and mass accreted and so must the oxygen fugacity of the
equilibrating material. The latter can occur if silicon partitions into the
core and through the late delivery of oxidized material. Coupled dynamical
accretion and multi-stage core formation models predict the evolving mantle and
core compositions of all the terrestrial planets simultaneously and also place
strong constraints on the bulk compositions and oxidation states of primitive
bodies in the protoplanetary disk.Comment: Accepted in Fischer, R., Terasaki, H. (eds), Deep Earth: Physics and
Chemistry of the Lower Mantle and Core, AGU Monograp
The SmithVent Experience and a Framework for Collaborative Distributed Design and Fabrication
This paper addresses the collaborative journey of the SmithVent team, a 30-person distributed group of volunteers, who designed, fabricated, and tested a simplified and cost-efficient ventilator over a three-month period, and won the CoVent19 Challenge in July 2020. The paper first presents the SmithVent experience through a co-constructed narrative that describes the team’s approaches to collaborative distributed design and fabrication. The paper next reviews frameworks from five theoretical lenses and then details the process of extracting, synthesizing, and organizing relevant factors to create a new and emergent framework reflective of the SmithVent experience. Lastly, the paper discusses educational implications of the SmithVent experience and proposed framework, emphasizing that the team’s strategies provide a model for educational and industry settings for future collaborative and distributed design and fabrication
Balancing the dilution and oddity effects: Decisions depend on body size
Background Grouping behaviour, common across the animal kingdom, is known to reduce an individual's risk of predation; particularly through dilution of individual risk and predator confusion (predator inability to single out an individual for attack). Theory predicts greater risk of predation to individuals more conspicuous to predators by difference in appearance from the group (the ‘oddity’ effect). Thus, animals should choose group mates close in appearance to themselves (eg. similar size), whilst also choosing a large group. Methodology and Principal Findings We used the Trinidadian guppy (Poecilia reticulata), a well known model species of group-living freshwater fish, in a series of binary choice trials investigating the outcome of conflict between preferences for large and phenotypically matched groups along a predation risk gradient. We found body-size dependent differences in the resultant social decisions. Large fish preferred shoaling with size-matched individuals, while small fish demonstrated no preference. There was a trend towards reduced preferences for the matched shoal under increased predation risk. Small fish were more active than large fish, moving between shoals more frequently. Activity levels increased as predation risk decreased. We found no effect of unmatched shoal size on preferences or activity. Conclusions and Significance Our results suggest that predation risk and individual body size act together to influence shoaling decisions. Oddity was more important for large than small fish, reducing in importance at higher predation risks. Dilution was potentially of limited importance at these shoal sizes. Activity levels may relate to how much sampling of each shoal was needed by the test fish during decision making. Predation pressure may select for better decision makers to survive to larger size, or that older, larger fish have learned to make shoaling decisions more efficiently, and this, combined with their size relative to shoal-mates, and attractiveness as prey items influences shoaling decisions
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