The development of a teachers' handbook in the Newton public schools

Thesis (Ed.M.)--Boston Universit

Evaluation of polymer coated attenuated total reflection (ATR) elements for the analysis of organic compounds in aqueous solution

A significant limitation of ATR/FTIR for the analysis of aqueous solutions is the relatively high bulk concentration of analyte required. One approach to improving the detection of an analyte is to incorporate a thin polymeric phase at the surface of the ATR element. The purpose of the polymeric phase is to extract the analyte of interest and concentrate it within the depth of penetration of the evanescent wave. Utilizing a very high molecular weight poly(vinyl chloride) phase the time necessary to reach equilibrium for a 0.05% (v/v) nitrobenzene in a 1.5% (w/v) methanol/water solution was over 60 minutes. A study was undertaken to determine if incorporating a plasticizer into the polymeric phase reduces the time required to reach the maximum level of absorbance achieved for the analyte. Specifically, the ability of phases which are mixtures of PVC and chloroparaffin plasticizers to concentrate analytes from aqueous solutions has been investigated. The results indicate that incorporating chloroparaffin into a PVC phase reduces the time required to reach the maximum absorbance for the analyte in an aqueous solution containing 1.5% methanol by approximately 45%. The addition of chloroparaffin also results in an increase in the absorbance observed for the analytes investigated in this study. Commercially available untapered and tapered chalcogenide fibers have been coated with poly(vinyl chloride) with plasticizer. These coated fibers were exposed to various analytes. All organic analytes provided readily detectable signals with the coated fibers but were not observable when the aqueous solution was sampled with the use of uncoated fibers. The results confirm the advantages of using a polymer coating to concentrate the analyte and reduced the water background for detecting non polar organic solutes in aqueous solutions

Ultrasonography-based evaluation and simulation of the hemodynamic consequences of arterial stenoses

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

Occupational light vehicle-use: a research driven strategy to improve surveillance and inform policy

Background: Occupational light vehicles (OLV) are light passenger and loadshaped vehicles used for work. The OLV-associated injury burden is as great as that of heavy vehicle users, but has been largely ignored by occupational health and safety (OHS) regulators. Contingent employment growth has accentuated existing gaps in the policy framework between OHS and road-safety. Frequent burden shifting from OHS to road-related health systems undermines the evidence base necessary to inform policy development. Aims: To provide evidence-based recommendations for the collection of OLVuser surveillance data and to underpin OHS procedures and policies for OLVusers. Method: The literature was systematically analyzed to identify OLV-user OHS policy and practice gaps. Strategies to improve and co-ordinate surveillance systems were developed to address the identified limitations. Results: Gaps were identified in OLV-user legislation, data collection, and riskmanagement. These require strategies to improve identification of all OLV-users and to co-ordinate surveillance and OHS practice. Discussion: Contemporary reform of road and OHS, policy, provides a timely opportunity for the implementation of strategic responses to this serious road safety and occupational, public health problem

A 10-hour period revealed in optical spectra of the highly variable WN8 Wolf-Rayet star WR 123

Aims. What is the origin of the large-amplitude variability in Wolf-Rayet WN8 stars in general and WR123 in particular? A dedicated spectroscopic campaign targets the ten-hour period previously found in the high-precision photometric data obtained by the MOST satellite. Methods. In June-August 2003 we obtained a series of high signal-to-noise, mid-resolution spectra from several sites in the {\lambda}{\lambda} 4000 - 6940 A^{\circ} domain. We also followed the star with occasional broadband (Johnson V) photometry. The acquired spectroscopy allowed a detailed study of spectral variability on timescales from \sim 5 minutes to months. Results. We find that all observed spectral lines of a given chemical element tend to show similar variations and that there is a good correlation between the lines of different elements, without any significant time delays, save the strong absorption components of the Hei lines, which tend to vary differently from the emission parts. We find a single sustained periodicity, P \sim 9.8 h, which is likely related to the relatively stable pulsations found in MOST photometry obtained one year later. In addition, seemingly stochastic, large-amplitude variations are also seen in all spectral lines on timescales of several hours to several days.Comment: 6 pages, 4 figures, 2 tables, data available on-line, accepted in A&A Research Note

β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3

INTRODUCTION: The Centiloid scale was developed to harmonise the quantification of β-amyloid (Aβ) PET images across tracers, scanners, and processing pipelines. However, several groups have reported differences across tracers and scanners even after centiloid conversion. In this study, we aim to evaluate the impact of different pre and post-processing harmonisation steps on the robustness of longitudinal Centiloid data across three large international cohort studies. METHODS: All Aβ PET data in AIBL (N = 3315), ADNI (N = 3442) and OASIS3 (N = 1398) were quantified using the MRI-based Centiloid standard SPM pipeline and the PET-only pipeline CapAIBL. SUVR were converted into Centiloids using each tracer\u27s respective transform. Global Aβ burden from pre-defined target cortical regions in Centiloid units were quantified for both raw PET scans and PET scans smoothed to a uniform 8 mm full width half maximum (FWHM) effective smoothness. For Florbetapir, we assessed the performance of using both the standard Whole Cerebellum (WCb) and a composite white matter (WM)+WCb reference region. Additionally, our recently proposed quantification based on Non-negative Matrix Factorisation (NMF) was applied to all spatially and SUVR normalised images. Correlation with clinical severity measured by the Mini-Mental State Examination (MMSE) and effect size, as well as tracer agreement in RESULTS: The smoothing to a uniform resolution partially reduced longitudinal variability, but did not improve inter-tracer agreement, effect size or correlation with MMSE. Using a Composite reference region for CONCLUSIONS: FWHM smoothing has limited impact on longitudinal consistency or outliers. A Composite reference region including subcortical WM should be used for computing both cross-sectional and longitudinal Florbetapir Centiloid. NMF improves Centiloid quantification on all metrics examined

Occupational light vehicle use: characterising the at-risk population

Previous occupational light vehicle research has concentrated on employees using cars. The aim of this study was to identify and characterise the total occupational light vehicle-user population and compare it with the privately-used light vehicle population. Occupational light vehicle and private light vehicle populations were identified through use-related 2003 registration categories from New South Wales Roads and Traffic Authority data. Key groups of occupational light vehicle registration variables were comparatively assessed as potential determinants of occupational light vehicleuser risks. These comparisons were expressed as odds ratios with 95% Confidence Intervals. The occupational light vehicle population vehicles (n=646,201) comprised 18% of all light vehicle registrations. A number of statistical differences emerge between the two populations. For instance, 86% of occupational light vehicle registrants were male versus 65% of private registrants, and 56% of the occupational users registered load shape vehicles versus 20% of the private registrants. Occupational light vehicles registered for farming or taxi use were more than six times more likely to belong to sole-traders than organisations. Sole-traders were nearly twice as likely to register light-trucks, and twice as likely to register older vehicles, than organisations. This study demonstrates that the occupational light vehicle user population is larger and more diverse than previously shown with characteristics likely to increase the relative risks of motor vehicle crashes. More occupational light vehicles were load shapes and therefore likely to have poorer crashworthiness ratings than cars. Occupational light vehicles are frequently used by sole-traders for activities with increased OHS risks including farming and taxi use. Further exploration of occupational light vehicle-user crash risks should include all vehicle types, work arrangements and small ‘fleets’

A hazardous substance exposure prevention rating method for intervention needs assessment and effectiveness evaluation: the Small Business Exposure Index

Aims This paper describes the refinement and adaptation to small business of a previously developed method for systematically prioritizing needs for intervention on hazardous substance exposures in manufacturing worksites, and evaluating intervention effectiveness. Methods We developed a checklist containing six unique sets of yes/no variables organized in a 2 × 3 matrix of exposure potential versus exposure protection at three levels corresponding to a simplified hierarchy of controls: materials, processes, and human interface. Each of the six sets of indicator variables was reduced to a high/moderate/low rating. Ratings from the matrix were then combined to generate an exposure prevention \u27Small Business Exposure Index\u27 (SBEI) Summary score for each area. Reflecting the hierarchy of controls, material factors were weighted highest, followed by process, and then human interface. The checklist administered by an industrial hygienist during walk-through inspection (N = 149 manufacturing processes/areas in 25 small to medium-sized manufacturing worksites). One area or process per manufacturing department was assessed and rated. A second hygienist independently assessed 36 areas to evaluate inter-rater reliability. Results The SBEI Summary scores indicated that exposures were well controlled in the majority of areas assessed (58% with rating of 1 or 2 on a 6-point scale), that there was some room for improvement in roughly one-third of areas (31% of areas rated 3 or 4), and that roughly 10% of the areas assessed were urgently in need of intervention (rated as 5 or 6). Inter-rater reliability of EP ratings was good to excellent (e.g., for SBEI Summary scores, weighted kappa = 0.73, 95% CI 0.52–0.93). Conclusion The SBEI exposure prevention rating method is suitable for use in small/medium enterprises, has good discriminatory power and reliability, offers an inexpensive method for intervention needs assessment and effectiveness evaluation, and complements quantitative exposure assessment with an upstream prevention focus

Cardio-metabolic impact of changing sitting, standing, and stepping in the workplace

According to cross-sectional and acute experimental evidence, reducing sitting time should improve cardio-metabolic health risk biomarkers. Furthermore, the improvements obtained may depend on whether sitting is replaced with standing or ambulatory activities. Based on data from the Stand Up Victoria multi-component workplace intervention, we examined this issue using compositional data analysis - a method that can examine and compare all activity changes simultaneously.Participants receiving the intervention (n=136 ≥0.6 full-time equivalent desk-based workers, 65% women, mean±SD age=44.6 ±9.1 years from seven worksites) were asked to improve whole-of-day activity by standing up, sitting less and moving more. Their changes in the composition of daily waking hours (activPAL-assessed sitting, standing, stepping) were quantified, then tested for associations with concurrent changes in cardio-metabolic risk (CMR) scores and 14 biomarkers concerning body composition, glucose, insulin and lipid metabolism. Analyses were by mixed models, accounting for clustering (3 months, n=105-120; 12 months, n=80-97).Sitting reduction was significantly (

Canada’s Earthquakes: ‘The Good, the Bad, and the Ugly’

Much of Canada is ‘earthquake country’. Tiny earthquakes (that can only be recorded by seismographs) happen every day. On average, earthquakes large enough to be felt occur every week in Canada, damaging earthquakes are years to decades apart, and some of the world’s largest earthquakes are typically separated by intervals of centuries. In this article, we provide details on the most significant earthquakes that have been recorded in, or near, Canada, including where and when they occurred, how they were felt, and the effects of those earthquakes. We also provide a brief review of how earthquakes are monitored across Canada and some recent earthquake hazard research. It is the results of this monitoring and research, which provide knowledge on earthquake hazard, that are incorporated into the National Building Code of Canada. This, in turn, will contribute to reduced property losses from future earthquakes across Canada. SOMMAIRE Un bonne partie du Canada est un ‘pays de séismes’. De petits séismes (que seuls les séismographes peuvent enregistrer) s’y produisent quotidiennement. En moyenne, un séisme assez fort pour qu’on le ressente s’y produit à intervalle d’une semaine; assez fort pour causer des dommages s’y produit à intervalle de quelques années à quelques décennies; alors que l’intervalle de récurrence des plus grands séismes est de l’ordre des siècles. Dans le présent article on trouvera des détails sur les plus importants séismes s’étant produits sur ou à proximité du territoire canadien, incluant le lieu et le moment, leurs manifestations et leurs répercussions. On y décrit sommairement les moyens de détection déployés sur le territoire canadien ainsi que quelques-unes des recherches récentes sur les risques sismiques. Ce sont les résultats des efforts de surveillance et des recherches sur les tremblements de terre qui ont été intégrés dans le Code national du bâtiment du Canada. Et cela aidera à amoindrir les répercussions des séismes à venir sur la propriété