49 research outputs found

    Physically active men show better semen parameters than their sedentary counterparts

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    CITATION: Lalinde-Acevedo, P. C., et al. 2017. Physically active men show better semen parameters than their sedentary counterparts. International Journal of Fertility and Sterility, 11(3):156-165, doi:10.22074/ijfs.2017.4881.The original publication is available at http://ijfs.irBackground: The quality of semen depends upon several factors such as environment, life style, physical activity, age, and occupation. The aim of this study was to analyze and compare the conventional and functional semen parameters in men practicing vigorous physical activity to those of sedentary men. Materials and Methods: In this descriptive cross-sectional study, semen samples of 17 physically active men and 15 sedentary men were collected for analysis. Semen analysis was performed according to the World Health Organization (WHO) guidelines, while functional parameters were evaluated by flow cytometry. Results: Results showed that several semen parameters (semen volume, viability, progressive motility, total motility, normal morphology, and moribund cells) were superior in the physically active group in comparison with the sedentary group. Semen parameters such as viability, progressive motility and total motility, as well as the percentage of moribund spermatozoa were significantly different between both groups. However, sperm DNA damage, lipid peroxidation and mitochondrial potential were not significantly different among the groups. Conclusion: Nevertheless, the physical activity shows better semen parameters than sedentary group. Taken together, our results demonstrate that regular physical activity has beneficial impact in sperm fertility parameters and such a life style can enhance the fertility status of men.http://ijfs.ir/journal/article/abstract/4881Publisher's versio

    Identification and characterization of Cardiac Glycosides as senolytic compounds

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    Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification. Senescent cells present a slightly depolarized plasma membrane and higher concentrations of H+, making them more susceptible to the action of CGs. These vulnerabilities can be exploited for therapeutic purposes as evidenced by the in vivo eradication of tumors xenografted in mice after treatment with the combination of a senogenic and a senolytic drug. The senolytic effect of CGs is also effective in the elimination of senescence-induced lung fibrosis. This experimental approach allows the identification of compounds with senolytic activity that could potentially be used to develop effective treatments against age-related diseases.We thank Matthias Drosten, Alejo Efeyan and Sean Morrison for plasmids. F.T-M. is a postdoctoral fellow from CONACYT (cvu 268632); P.P. is a predoctoral fellow from Xunta de Galicia; M.C. is a "Miguel Servet II" investigator (CPII16/00015). P.P.-R. receives support from a program by the Deputacion de Coruna (BINV-CS/2019). Work in the laboratory of M.C. is funded by grant RTI2018-095818-B-100 (MCIU/AEI/FEDER, UE). P.J.F.-M. is funded by the IMDEA Food Institute, the Ramon Areces Foundation, (CIVP18A3891), and a Ramon y Cajal Award (MICINN) (RYC-2017-22335). M.P.I. is funded by Talento Modalidad-1 Program Grant, Madrid Regional Government (#2018-T1/BIO-11262). F.P. was funded by a Long Term EMBO Fellowship (ALTF-358-2017) and F.H-G. was funded by the PhD4MD Programme of the IRB, Hospital Clinic and IDIBAPS. Work in the laboratory of M.S. was funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) (SAF2013-48256-R), the European Research Council (ERC-2014-AdG/669622), and "laCaixa" Foundation.S

    Estudio cualitativo sobre decisión vocacional

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    El estudio cualitativo sobre decisión vocacional reúne los resultados del análisis realizado a estudiantes que participaron de la estrategia Monitores Líderes del Plan Digital Itagüí y que están cerca de finalizar los estudios de secundaria. La exploración buscó identificar los factores incidentes en la decisión sobre los planes de estudio, además de las posibles tendencias y áreas de profundización frente al tema de decisión vocacional

    Estudio cualitativo sobre cultura de innovación

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    El estudio cualitativo sobre cultura de innovación plantea un análisis sobre el desarrollo del tema en el municipio de Itagüí, Antioquia; y el nivel de innovación que presentan las instituciones educativas que han pasado por el Plan Digital Itagüí al incorporar prácticas mediadas con tecnología

    Modelo UbiTAG: Una propuesta integral de incorporación de TIC en educación básica y media

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    La Línea de Investigación I+D en Informática Educativa de la Universidad EAFIT, diseñó, estructuró y puso en marcha un conjunto de soluciones para la incorporación de tecnologías en la educación que fueron formalizadas en el Modelo UbiTAG, propuesta de aprendizaje ubicuo que aporta en el proceso de interacción entre la tecnología, el aprendizaje y la gestión educativa de forma coordinada para facilitar la formulación de propuestas educativas exitosas

    NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

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    Xenarthrans – anteaters, sloths, and armadillos – have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with 24 domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, ten anteaters, and six sloths. Our dataset includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data-paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the south of the USA, Mexico, and Caribbean countries at the northern portion of the Neotropics, to its austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n=5,941), and Cyclopes sp. has the fewest (n=240). The armadillo species with the most data is Dasypus novemcinctus (n=11,588), and the least recorded for Calyptophractus retusus (n=33). With regards to sloth species, Bradypus variegatus has the most records (n=962), and Bradypus pygmaeus has the fewest (n=12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other datasets of Neotropical Series which will become available very soon (i.e. Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans dataset

    L’utilizzo della network analysis nello studio del fenomeno mafioso: uno studio di caso

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    In this work we present the results of applying the INQUA intensity scale to the analysis of the environmental effects of 12 moderate-to-large earthquakes with moment magnitudes (Mw) in the range 5.6-8.1 that shook Colombia between 1970 and 2004. These earthquakes were selected following consideration of their depths, magnitudes, and relevance of effects during shaking. After analysis of shaking effects, we found that earthquakes in Colombia could be assigned INQUA intensities between 6 and 11. For a subgroup of seven earthquakes, we found a positive correlation between INQUA intensities and Mw defined by a best-fit linear trend with a correlation coefficient of 0.7 and a positive correlation between INQUA intensities and Modified Mercalli intensities with a correlation coefficient of 0.6. The INQUA scale allowed us to compare local earthquakes with other earthquakes worldwide and to analyze each earthquake to better understand the ground response in Colombia to the shaking during shallow earthquakes. We conclude that, in general, the INQUA scale provides a good estimate of intensity that may complement other measures of intensity
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