103 research outputs found
CERN Axion Solar Telescope as a probe of large extra dimensions
We explore the potential of the CERN Axion Solar Telescope (CAST) for testing
the presence of large extra dimensions. The CAST experiment has originally been
proposed to search for solar axions with a sensitivity supposed to provide a
limit on the axion-photon coupling g_{a\gamma\gamma}<5x10^{-11} GeV^{-1} or
even lower. The expected bound on the coupling constant is by a factor of ten
more stringent than the current experimental results. This bound extends for
the first time beyond the limit dictated by astrophysical considerations. As a
tuning experiment planning to explore the axion mass region up to about 1 eV,
CAST would also be sensitive to the existence of Kaluza-Klein massive states.
Therefore, the detection of X-rays at least at two pressures may be the
signature of large extra dimensions. From this requirement we find that CAST
may test (two) large extra dimensions with a (common) compactification radius R
down to around 250 nm if m_{PQ}<1/(2R), and down to around 370 nm if
1/(2R)<m_{PQ}, where m_{PQ} is the Peccei-Quinn mass.Comment: Version to appear in Phys. Rev. D. Changes to the total rate formula
in Sec. III. Conclusions remain essentially unchanged; 5 pages, 2 figures,
revtex
Uspostavljanje programa selektivnog uzgoja kalifornijske pastrmke (oncorhynchus mykiss, walbaum) u Srbiji
Zahtev za sve većim količinama hrane za ljudsku upotrebu, efikasnost iskorišćavanja hraniva i prostora za gajenje domaćih životinja, kao i pojava mnogih bolesti doveli su do intenzivnog razvijanja selekcionih programa u svim granama poljoprivrede. Za razliku od ostalih gajenih životinja, programi selekcije u akvakulturi su se razvili nešto kasnije usled nedostatka potrebnih procena heritabilnosti, koeficijenata varijacija i korelacija za ekonomski bitne osobine. Trenutno se u akvakulturi samo 1-2% od ukupne proizvodnje zasniva na genetički unapređenim vrstama riba (Gjedrem, 1997). Korišćenjem selektovanih linija riba postiže se više korisnih stvari. Na prvom mestu, programi selekcije riba predstavljaju jedini način stalnog unapređenja ekonomski bitnih osobina kao sto su prirast, konverzija hrane, otpornost na bolesti, smanjenje masnoće u mesu riba. Ribe iz selektovanih linija efikasnije iskorišćavaju hraniva i na taj način smanjuju pritisak na divlje populacije riba koje se koriste za proizvodnju ribljeg brašna, kao glavnog izvora proteina u smešama za ishranu pastrmki. Ribe koje potiču iz divljine ne napreduju zadovoljavajućim brzinom, što znači da su konstantno pod stresom, za razliku od riba poreklom iz selekcionih programa koje pokazuju manji uticaj stresa usled gajenja u zarobljeništvu. Tako se na ovaj način korišćenjem selektovanih linija riba postiže efikasna i održiva proizvodnja uz vođenje računa o dobrobiti životinja. Drugi dobar razlog za uspostavljanje programa selekcije pastrmke u Srbiji je dobro dokumentovano postojanje interakcije genotip x okolina kod kalifornijske pastrmke, kao što su pokazala istraživanja (McKay et al., 1984; Hanke et al., 1989; Sylven et al., 1991; Winkelman and Peterson, 1994; Kettunen et al., 1999; Kause et al., 2003). Na kraju, ali ne i najmanje važna je i kontrola bolesti kod kalifornijske pastrmke i mogućnost stvaranja otpornih linija pastrmki na neke bolesti putem selektivnog uzgoja (Henrion, 2005). Jedno od rešenja za ovaj ozbiljan problem, pored boljeg sistema kontrole pastrmske ikre poreklom iz uvoza, je i stvaranje lokalnih selektovanih matičnih jata sa proverenim poreklom i povećenom otpornošću na bolesti.
Obzirom da za kalifornijsku pastrmku postoje pouzdani podaci o varijabilnosti i heritabilnosti proizvodnih osobina ovo pruža mogućnost efikasne selekcije, a samom tim i značajnog unapređenja proizvodnje uz smanjen ukupni mortalitet, putem odgovarajućeg programa selekcije u Srbiji
Towards a new generation axion helioscope
We study the feasibility of a new generation axion helioscope, the most
ambitious and promising detector of solar axions to date. We show that large
improvements in magnetic field volume, x-ray focusing optics and detector
backgrounds are possible beyond those achieved in the CERN Axion Solar
Telescope (CAST). For hadronic models, a sensitivity to the axion-photon
coupling of \gagamma\gtrsim {\rm few} \times 10^{-12} GeV is
conceivable, 1--1.5 orders of magnitude beyond the CAST sensitivity. If axions
also couple to electrons, the Sun produces a larger flux for the same value of
the Peccei-Quinn scale, allowing one to probe a broader class of models. Except
for the axion dark matter searches, this experiment will be the most sensitive
axion search ever, reaching or surpassing the stringent bounds from SN1987A and
possibly testing the axion interpretation of anomalous white-dwarf cooling that
predicts of a few meV. Beyond axions, this new instrument will probe
entirely unexplored ranges of parameters for a large variety of axion-like
particles (ALPs) and other novel excitations at the low-energy frontier of
elementary particle physics.Comment: 37 pages, 11 figures, accepted for publication in JCA
The International Axion Observatory (IAXO)
The International Axion Observatory (IAXO) is a new generation axion
helioscope aiming at a sensitivity to the axion-photon coupling of a few
10 GeV, i.e. 1 - 1.5 orders of magnitude beyond the one currently
achieved by CAST. The project relies on improvements in magnetic field volume
together with extensive use of x-ray focusing optics and low background
detectors, innovations already successfully tested in CAST. Additional physics
cases of IAXO could include the detection of electron-coupled axions invoked to
solve the white dwarfs anomaly, relic axions, and a large variety of more
generic axion-like particles (ALPs) and other novel excitations at the
low-energy frontier of elementary particle physics. This contribution is a
summary of our paper [1] to which we refer for further details.Comment: 4 pages, 2 figures. To appear in the proceedings of the 7th Patras
Workshop on Axions, WIMPs and WISPs, Mykonos, Greece, 201
Legumain in acute coronary syndromes: A substudy of the PLATO (Platelet Inhibition and Patient Outcomes) trial
Background
The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the association of legumain with clinical outcome in a large cohort of patients with acute coronary syndrome.
Methods and Results
Serum levels of legumain were analyzed in 4883 patients with acute coronary syndrome from a substudy of the PLATO (Platelet Inhibition and Patient Outcomes) trial. Levels were analyzed at admission and after 1 month follow‐up. Associations between legumain and a composite of cardiovascular death, spontaneous myocardial infarction or stroke, and its individual components were assessed by multivariable Cox regression analyses. At baseline, a 50% increase in legumain level was associated with a hazard ratio (HR) of 1.13 (95% CI, 1.04–1.21), P=0.0018, for the primary composite end point, adjusted for randomized treatment. The association remained significant after adjustment for important clinical and demographic variables (HR, 1.10; 95% CI, 1.02–1.19; P=0.013) but not in the fully adjusted model. Legumain levels at 1 month were not associated with the composite end point but were negatively associated with stroke (HR, 0.62; 95% CI, 0.44–0.88; P=0.0069), including in the fully adjusted model (HR, 0.57; 95% CI, 0.37–0.88; P=0.0114).
Conclusions
Baseline legumain was associated with the primary outcome in patients with acute coronary syndrome, but not in the fully adjusted model. The association between high levels of legumain at 1 month and decreased occurrence of stroke could be of interest from a mechanistic point of view, illustrating the potential dual role of legumain during atherogenesis and acute coronary syndrome.
Registration
URL: https://www.clinicaltrials.gov; Unique identifier: NCT00391872
CAST constraints on the axion-electron coupling
In non-hadronic axion models, which have a tree-level axion-electron
interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton
scattering, and axio-recombination, the "BCA processes." Based on a new
calculation of this flux, including for the first time axio-recombination, we
derive limits on the axion-electron Yukawa coupling g_ae and axion-photon
interaction strength g_ag using the CAST phase-I data (vacuum phase). For m_a <
10 meV/c2 we find g_ag x g_ae< 8.1 x 10^-23 GeV^-1 at 95% CL. We stress that a
next-generation axion helioscope such as the proposed IAXO could push this
sensitivity into a range beyond stellar energy-loss limits and test the
hypothesis that white-dwarf cooling is dominated by axion emission
Solar axion search with the CAST experiment
The CAST (CERN Axion Solar Telescope) experiment is searching for solar
axions by their conversion into photons inside the magnet pipe of an LHC
dipole. The analysis of the data recorded during the first phase of the
experiment with vacuum in the magnet pipes has resulted in the most restrictive
experimental limit on the coupling constant of axions to photons. In the second
phase, CAST is operating with a buffer gas inside the magnet pipes in order to
extent the sensitivity of the experiment to higher axion masses. We will
present the first results on the data taking as well as the
system upgrades that have been operated in the last year in order to adapt the
experiment for the data taking. Expected sensitivities on the
coupling constant of axions to photons will be given for the recent run just started in March 2008.Comment: Proceedings of the ICHEP 2008 conferenc
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Objectives
Biomarker concentrations and their changes during acute coronary syndrome (ACS) provide clinically useful information on pathophysiological processes, e.g. myocardial necrosis, hemodynamic stress and inflammation. However, current evidence on temporal biomarker patterns early during ACS is limited, and studies investigating multiple biomarkers are lacking.
Methods
We measured concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI), NT-terminal pro-B-type natriuretic peptide, C-reactive protein, and growth-differentiation factor-15 (GDF-15) in plasma samples obtained at randomization in ACS patients from the PLATelet inhibition and patient Outcomes (PLATO) trial. Linear regressions with interaction analyses were used to investigate the associations of biomarker concentrations with the time from symptom onset and to model temporal biomarker concentration patterns.
Results
The study population consisted of 16,944 patients (median age 62 years; 71.3 % males) with 6,853 (40.3 %) having ST-elevation myocardial infarction (STEMI) and 10,141 (59.7 %) having non-ST-elevation ACS (NSTE-ACS). Concentrations of all biomarkers were associated with time from symptom onset (pinteraction<0.001), apart for GDF-15 (pinteraction=0.092). Concentration increases were more pronounced in STEMI compared to NSTE-ACS. Temporal biomarker patterns for hs-cTnT and hs-cTnI were different depending on sex whereas biomarker patterns for the other biomarkers were similar in cohorts defined by age and sex.
Conclusions
Temporal concentration patterns differ for various biomarkers early during ACS, reflecting the variability in the activation and duration of different pathophysiological processes, and the amount of injured myocardium. Our data emphasize that the time elapsed from symptom onset should be considered for the interpretation of biomarker results in ACS
CAST solar axion search with 3^He buffer gas: Closing the hot dark matter gap
The CERN Axion Solar Telescope (CAST) has finished its search for solar
axions with 3^He buffer gas, covering the search range 0.64 eV < m_a <1.17 eV.
This closes the gap to the cosmological hot dark matter limit and actually
overlaps with it. From the absence of excess X-rays when the magnet was
pointing to the Sun we set a typical upper limit on the axion-photon coupling
of g_ag < 3.3 x 10^{-10} GeV^{-1} at 95% CL, with the exact value depending on
the pressure setting. Future direct solar axion searches will focus on
increasing the sensitivity to smaller values of g_a, for example by the
currently discussed next generation helioscope IAXO.Comment: 5 pages, 2 figures. Last version uploade
Production properties of K*(892) vector mesons and their spin alignment as measured in the NOMAD experiment
First measurements of K*(892) mesons production properties and their spin
alignment in nu_mu charged current (CC) and neutral current (NC) interactions
are presented. The analysis of the full data sample of the NOMAD experiment is
performed in different kinematic regions. For K*+ and K*- mesons produced in
nu_mu CC interactions and decaying into K0 pi+/- we have found the following
yields per event: (2.6 +/- 0.2 (stat.) +/- 0.2 (syst.))% and (1.6 +/- 0.1
(stat.) +/- 0.1 (syst.))% respectively, while for the K*+ and K*- mesons
produced in nu NC interactions the corresponding yields per event are: (2.5 +/-
0.3 (stat.) +/- 0.3 (syst.))% and (1.0 +/- 0.3 (stat.) +/- 0.2 (syst.))%. The
results obtained for the rho00 parameter, 0.40 +/- 0.06 (stat) +/- 0.03 (syst)
and 0.28 +/- 0.07 (stat) +/- 0.03 (syst) for K*+ and K*- produced in nu_mu CC
interactions, are compared to theoretical predictions tuned on LEP measurements
in e+e- annihilation at the Z0 pole. For K*+ mesons produced in nu NC
interactions the measured rho00 parameter is 0.66 +/- 0.10 (stat) +/- 0.05
(syst).Comment: 20 p
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