THE EVALUATION AND SELECTION OF SUPPLIERS – IN A LEAN APPROACH

Lean management has become a popular concept in the last decades, the principles permeate the present business strategies as well. Of course, lean management goes beyond the limits of one company. The real benefits are reflected if it is applied for complex supply chains. An important challenge is enhancing the lean approach to direct partners. The paper draws up the possibilities from the viewpoint of quality management that can cover the fact that a supplier is the source of both opportunities and risks. The focus is on the supplier evaluation and selection in order to explore and to prevent the potential losses of poor external compliance. Next to the theoretical reasoning the paper includes some short case studies based on the author’s experiences in order to present the limitations and the considerable good practices

Prolog to the section on wireless communications technology

The authors take a look at the existing 3G systems in service and investigate the capabilities of 4G, and while the theoretical throughput of these cellular systems is expected to be high, the future promises to offer more technological improvements and innovations.<br/

OFFICE WORK: ERGONOMIC AND MEDICAL ASPECTS

A special attention must be given to office work in order to increase efficiency of the corporation and to preserve the health of the workforce. Physical work is easier to plan and to measure because the tasks are predictable and repeatable in a high volume. Office work includes various activities with difficulties in estimating time- and resource need. Physical and mental flexibility of people bridges the challenges of continuous working but there are many long term adverse effects. The paper looks the impacts of office work environment on the muscular-skeletal system of ergonomic perspective. People spend several hours every day sitting in front of the computer during work and non-work activities. Although technologically the development of computer technology is dynamic, people may criticize the results from the ergonomic point of view. Economic aspects and lack of knowledge together may lead to the development of a work environment, which discourages effective work. The most common problems come from the bad sitting posture, the wrong positioning of the mouse or the keyboard on the table and the improper selection of tools and gadgets in the direct work environment. These lead to mutation of human muscular-skeletal system. Next to this the static muscle load results short term problems as well. The experiences of our empiric research shows that factors of individual satisfaction may differ from the professional viewpoint of ergonomics and medical sciences. This is why exploring the possibilities of convergence is important, including knowledge dissemination or promotion of prevention exercises

Kecsketartó gazdaság vizsgálata

A Dunaszigeten 300 anyával működÅ‘ gazdaság eredményességében kulcskérdés a termelési költségek csökkentése, mindenekelÅ‘tt a takarmányozás, az egyéb (áram, tejvizsgálat, bérleti díjak stb.), valamint a munkabérköltségek mérséklése. A bevételi oldalon növekvÅ‘ jelentÅ‘ségű – a kecsketej- és gidaértékesítés mellett – egyre nagyobb arányban a sajtértékesítés. A jövÅ‘t illetÅ‘en a kockázati tényezÅ‘k és a fejlesztési lehetÅ‘ségek számbavétele, a helyi lehetÅ‘ségek hasznosítása, s az egészségre kedvezÅ‘ hatású tej és sajt megismertetése a meghatározó. ------------------------------------ The success of the farm using 300 mother goats depended on the reduction of production costs including especially that of fodder and others (electricity, milk testing, rent, etc) and the moderation of taxes and dues on labour costs. On the income side selling of milk and goat kid apart merchandising goat cheese is increasingly popular. As for the future it is essential to assess the risk factors and local development opportunities and to bring the attention of consumers to the favourable health effects of goat milk and cheese.kecske, termékek, kockázatok, fejlesztések, goat, products, risks, developments, Farm Management, Livestock Production/Industries, Production Economics,

'Limes route' the next world heritage site in Hungary

The frontier of Pannonia, which stretched from Klostenburg to Belgrade, was one of the most important borderlines of the Empire. This is proved by the strong military power concentrated in Pannonia from the second half of the 1st century onwards. A 400-km-long section of it lies on the territory of present day Hungary. There is a large archaeological area in Budapest (Aquincum), with quite a few monuments, such as parts of the legionary fortress, the military amphitheatre and the whole quarter of a preserved civil town (Figure 2). The watch-towers are - especially from the late Roman period and around the Danube Bend - at a distance of 1 to 2 km apart from each other (ripapannonica.hu). During the first century AD some auxiliary forces were stationed along the main routes leading across the country to the fortifications at the Danube bank

A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty

Mosaicplasty has become a well-accepted treatment modality for articular cartilage lesions in the knee. Postoperative bleeding remains potentially concerning. This study evaluates the porous poly(ethylene oxide)terephthalate/poly(butylene terephthalate) (PEOT/PBT) implants used for donor site filling. Empty donor sites were the controls. After 9 months, MRI, macroscopical and histological analysis were carried out. Treated defects did not cause postoperative bleeding. No adverse events or inflammatory response was observed. PEOT/PBT implants were well integrated. Empty controls occasionally showed protrusion of repair tissue at the defect margins. Surface stiffness was minimally improved compared to controls. Existing polymer fragments indicated considerable biodegradation. Histological evaluation of the filled donor sites revealed congruent fibrocartilaginous surface repair with proteoglycan-rich domains and subchondral cancellous bone formation with interspersed fibrous tissue in all implanted sites. The PEOT/PBT implants successfully reduce donor site morbidity and postoperative bleeding after mosaicplasty

Q134R: Small Chemical Compound with NFAT Inhibitory Properties Improves Behavioral Performance and Synapse Function in Mouse Models of Amyloid Pathology

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging-related Alzheimer\u27s disease (AD)-like pathology. However, concerns over adverse effects have slowed the transition of common CN-inhibiting drugs to the clinic for the treatment of AD and AD-related disorders. Targeting substrates of CN, like the nuclear factor of activated T cells (NFATs), has been suggested as an alternative, safer approach to CN inhibitors. However, small chemical inhibitors of NFATs have only rarely been described. Here, we investigate a newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity. Q134R partially inhibited NFAT activity in primary rat astrocytes, but did not prevent CN-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro. Acute (≤1 week) oral delivery of Q134R to APP/PS1 (12 months old) or wild-type mice (3–4 months old) infused with oligomeric Aβ peptides led to improved Y maze performance. Chronic (≥3 months) oral delivery of Q134R appeared to be safe, and, in fact, promoted survival in wild-type (WT) mice when given for many months beyond middle age. Finally, chronic delivery of Q134R to APP/PS1 mice during the early stages of amyloid pathology (i.e., between 6 and 9 months) tended to reduce signs of glial reactivity, prevented the upregulation of astrocytic NFAT4, and ameliorated deficits in synaptic strength and plasticity, without noticeably altering parenchymal Aβ plaque pathology. The results suggest that Q134R is a promising drug for treating AD and aging-related disorders

Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells

The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and caveolae, cholesterol-rich PM invaginations, constitute clustering platforms for proteins functional in signaling cascades. Here, we aimed to compare the effect of cyclodextrin (MβCD)- and nystatin-induced cholesterol modulations on stress-activated expression of the representative HSPs, HSP70, and HSP25 in mouse B16-F10 melanoma cells. Depletion of cholesterol levels with MβCD impaired the heat-inducibility of both HSP70 and HSP25. Sequestration of cholesterol with nystatin impaired the heat-inducibility of HSP25 but not of HSP70. Imaging fluorescent correlation spectroscopy marked a modulated lateral diffusion constant of fluorescently labelled cholesterol in PM during cholesterol deprived conditions. Lipidomics analysis upon MβCD treatment revealed, next to cholesterol reductions, decreased lysophosphatidylcholine and phosphatidic acid levels. These data not only highlight the involvement of PM integrity in HSR but also suggest that altered dynamics of specific cholesterol pools could represent a mechanism to fine tune HSP expression