4 research outputs found
Barriers to medication counselling for people with mental health disorders : A six country study
Provision of medication information may improve adherence and prevent medication related problems. People with mental health disorders commonly receive less medication counselling from pharmacists than people with other common long term and persistent disorders. Objective: The objective of this study was to compare and contrast barriers pharmacy students perceive toward providing medication counselling for people with mental health disorders in Australia, Belgium, Estonia, Finland, India and Latvia. Methods: Barriers identified by third-year pharmacy students as part of the International Pharmacy Students' Health Survey were content analysed using a directed approach. Students' responses were categorised as pharmacist related, patient related, health-system related, or social or cultural related. Quantitative data were analysed using SPSS version 14.0. Results: Survey instruments were returned by 649 students. Of the respondents, 480 identified one or more barriers to medication counselling for people with mental health disorders. Patient related factors accounted for between 25.3% and 36.2% of barriers identified by the pharmacy students. Pharmacist related factors accounted for between 17.6% and 45.1% of the barriers identified by the pharmacy students. Students in India were more likely to attribute barriers to pharmacist and social and cultural related factors, and less likely to healthsystem related factors, than students studying in other countries. Conclusion: The nature of barriers identified by pharmacy students differed according to the country in which they studied. Undergraduate and postgraduate pharmacy education programs may need to be amended to address common misconceptions among pharmacy students.publishersversionPeer reviewe
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe
Barriers to medication counselling for people with mental health disorders: a six country study
Provision of medication information may improve
adherence and prevent medication related
problems. People with mental health disorders
commonly receive less medication counselling from
pharmacists than people with other common long
term and persistent disorders.
Objective: The objective of this study was to
compare and contrast barriers pharmacy students
perceive toward providing medication counselling
for people with mental health disorders in Australia,
Belgium, Estonia, Finland, India and Latvia.
Methods: Barriers identified by third-year pharmacy
students as part of the International Pharmacy
Students� Health Survey were content analysed
using a directed approach. Students� responses
were categorised as pharmacist related, patient
related, health-system related, or social or cultural
related. Quantitative data were analysed using
SPSS version 14.0.
Results: Survey instruments were returned by 649
students. Of the respondents, 480 identified one or
more barriers to medication counselling for people
with mental health disorders. Patient related factors
accounted for between 25.3% and 36.2% of barriers identified by the pharmacy students. Pharmacist
related factors accounted for between 17.6% and
45.1% of the barriers identified by the pharmacy
students. Students in India were more likely to
attribute barriers to pharmacist and social and
cultural related factors, and less likely to healthsystem
related factors, than students studying in
other countries.
Conclusion: The nature of barriers identified by
pharmacy students differed according to the country
in which they studied. Undergraduate and
postgraduate pharmacy education programs may
need to be amended to address common
misconceptions among pharmacy students.puede mejorar la adherencia y prevenir problemas
relacionados con los medicamentos. Las personas
con desordenes mentales normalmente reciben
menos consejos sobre medicación de los
farmacéuticos que la gente con otras enfermedades
comunes de larga duración.
Objetivo: El objetivo de este estudio fue comparar
y contrastar las barreras que los estudiantes de
farmacia perciben hacia proporcionar consejos de
medicación para personas con desordenes mentales
en Australia, Bélgica, Estonia, Finlandia, India y
Letonia.
Métodos: Se realizó un análisis de contenido de
abordaje directo de las barreras identificadas pro
estudiantes de tercero de farmacia como parte de la
Encuesta de Salud de los Estudiantes de Farmacia.
Las respuestas de los estudiantes se categorizaron
como relativas al farmacéutico, relativas al
paciente, relativas al sistema de salud, o relativas a
aspectos sociales o culturales. Los datos
cuantitativos se analizaron utilizando un SPSS
versión 14.0.
Resultados: Las encuestas fueron retornadas por
649 estudiantes. De los respondentes, 480
identificaron una o más barreras al consejo sobre
medicación para personas con desordenes mentales.
Los factores relativos al paciente representaron
entre el 25,3% y el 36,2% de las barreras identificadas por los estudiantes. Los factores
relativos al farmacéutico alcanzaron el 17,6% a
45,1% de las barreras identificadas. Los estudiantes
de India eran más proclives a atribuir barreras al
farmacéutico y a los aspectos sociales y culturales,
y menos a los factores del sistema de salud que los
estudiantes de otros países.
Conclusión: La naturaleza de las barreras
identificadas por los estudiantes de farmacia difirió
entre los países estudiados. Los programas de
formación pre y postgraduados en farmacia podrían
tener que corregirse para encarar los malos
entendidos comunes entre los estudiantes de
farmacia
Heme oxygenase-1 repeat polymorphism in septic acute kidney injury
Abstract
Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the replicability of this finding in a Finnish cohort of critically ill septic patients. This multicenter study was part of the national FINNAKI study. We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine–thymine (GTn) repeat in the promoter region of the HMOX1 gene. The allele calling was based on the number of repeats, the cut off being 27 repeats in the S–L (short to long) classification, and 27 and 34 repeats for the S–M–L₂ (short to medium to very long) classification. The plasma concentrations of heme oxygenase-1 (HO-1) enzyme were measured on admission. The allele distribution in our patients was similar to that published previously, with peaks at 23 and 30 repeats. The S-allele increases AKI risk. An adjusted OR was 1.30 for each S-allele in an additive genetic model (95% CI 1.01–1.66; p = 0.041). Alleles with a repeat number greater than 34 were significantly associated with lower HO-1 concentration (p<0.001). In septic patients, we report an association between a short repeat in HMOX1 and AKI risk