Native born but not yet citizen:citizenship and education outcomes of the children of immigrants in the Netherlands

This dissertation investigates the relationship between citizenship and the educational outcomes of native-born children of immigrants in the Netherlands. As in many countries of the world, children born in the Netherlands do not have rights to the citizenship of their country of birth but instead inherit the citizenship of their parents. Little is known about whether and how such citizenship laws affect their legal status and life course. Based on administrative register data, the dissertation uses quantitative methods to map the patterns of citizenship acquisition among the children of immigrants and to analyse its effects on their educational trajectories and performance. Findings indicate that children who acquired Dutch citizenship have a substantial educational advantage over those who are still foreign citizens. Yet the effects of citizenship are not uniform: Dutch citizenship matters especially when acquired in early childhood, and by families facing structural constraints in the host society. The dissertation therefore provides a better understanding of the relevance of citizenship for children of immigrants, taking into account their life course and family environment

Review. Divergent selection for residual feed intake in the growing pig

To view supplementary material for this article, please visit https:/doi.org/10.1017/S175173111600286XThis review summarizes the results from the INRA (Institut National de la Recherche Agronomique) divergent selection experiment on residual feed intake (RFI) in growing Large White pigs during nine generations of selection. It discusses the remaining challenges and perspectives for the improvement of feed efficiency in growing pigs. The impacts on growing pigs raised under standard conditions and in alternative situations such as heat stress, inflammatory challenges or lactation have been studied. After nine generations of selection, the divergent selection for RFI led to highly significant ( P<0.001) line differences for RFI (−165 g/day in the low RFI (LRFI) line compared with high RFI line) and daily feed intake (−270 g/day). Low responses wereobserved on growth rate (−12.8 g/day, P <0.05) and body composition (+0.9mm backfat thickness, P = 0.57; −2.64% lean meat content, P<0.001) with a marked response on feed conversion ratio (−0.32 kg feed/kg gain, P<0.001). Reduced ultimate pH and increased lightness of the meat ( P<0.001) were observed in LRFI pigs with minor impact on the sensory quality of the meat. These changes in meat quality were associated with changes of the muscular energy metabolism. Reduced maintenance energy requirements (−10% after five generations of selection) and activity (−21% of time standing after six generations of selection) of LRFI pigs greatly contributed to the gain in energy efficiency. However, the impact of selection for RFI on the protein metabolism of the pig remains unclear. Digestibility of energy and nutrients was not affected by selection, neither for pigs fed conventional diets nor for pigs fed high-fibre diets. A significant improvement of digestive efficiency could likely be achieved by selecting pigs on fibre diets. No convincing genetic or blood biomarker has been identified for explaining the differences in RFI, suggesting that pigs have various ways to achieve an efficient use of feed. No deleterious impact of the selection on the sow reproduction performance was observed. The resource allocation theory states that low RFI may reduce the ability to cope with stressors,via the reduction of a buffer compartment dedicated to responses to stress. None of the experiments focussed on the response of pigs to stress or challenges could confirm this theory. Understanding the relationships between RFI and responses to stress and energy demanding processes, as such immunity and lactation, remains a major challenge for a better understanding of the underlying biological mechanisms of the trait and to reconcile the experimental results with the resource allocation theory

Antilymphocyte globulin for matched sibling donor transplantation in patients with myelofibrosis

The use of antihuman T-lymphocyte immunoglobulin in the setting of transplantation from an HLA-matched related donor is still much debated. Acute and chronic graft-versus-host disease are the main causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. The aim of this study was to evaluate the effect of antihuman T-lymphocyte immunoglobulin in a large cohort of patients with myelofibrosis (n= 287). The cumulative incidences of grade II-IV acute graft-versus-host disease among patients who were or were not given antihuman T-lymphocyte immunoglobulin were 26% and 41%, respectively. The corresponding incidences of chronic graft-versus-host disease were 52% and 55%, respectively. Non-adjusted overall survival, disease-free survival and non-relapse mortality rates were 55% versus 53%, 49% versus 45%, and 32% versus 31%, respectively, among the patients who were or were not given antihuman T-lymphocyte immunoglobulin. An adjusted model confirmed that the risk of acute graft-versus-host disease was lower following antihuman T-lymphocyte immunoglobulin (hazard ratio, 0.54; P= 0.010) while it did not decrease the risk of chronic graft-versus-host disease. The hazard ratios for overall survival and non-relapse mortality were 0.66 and 0.64, with P-values of 0.05 and 0.09, respectively. Antihuman T-lymphocyte immunoglobulin did not influence disease-free survival, graft-versus-host disease, relapse-free survival or relapse risk. In conclusion, in the setting of matched related transplantation in myelofibrosis patients, this study demonstrates that antihuman T-lymphocyte immunoglobulin decreases the risk of acute graft-versushost disease without increasing the risk of relapse.Peer reviewe

Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS.

peer reviewedAllogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups (p < 0.001). The overall survival was significantly different between the three groups with a better OS observed in the MUD group (p = 0.014). This observation could be explained by a higher progression-free survival with MUD (p = 0.014). The cumulative incidence of grade 2-4 acute GvHD was significantly higher in the HID group (p = 0.051). However, in multivariable analysis, patients transplanted using an HID had comparable mortality to patients transplanted using a MUD (subdistribution hazard ratio [sHR]: 0.58 [0.32-1.07]; p = 0.080) and a MSD ([sHR]: 0.56 [0.28-1.11]; p = 0.094). MUD do not remain a significant positive predictor of survival, suggesting that beyond the donor-recipient HLA matching, the donor age might impact recipient outcome

Late relapse after hematopoietic stem cell transplantation for acute leukemia: a retrospective study by SFGM-TC.

peer reviewedLate relapse (LR) after allogeneic hematopoietic stem cell transplantation (AHSCT) for acute leukemia is a rare event (nearly 4.5%) and raises the questions of prognosis and outcome after salvage therapy. We performed a retrospective multicentric study between January 1, 2010, and December 31, 2016, using data from the French national retrospective register ProMISe provided by the SFGM-TC (French Society for Bone Marrow Transplantation and Cellular Therapy). We included patients presenting with LR, defined as a relapse occurring at least 2 years after AHSCT. We used the Cox model to identify prognosis factors associated with LR. During the study period, a total of 7582 AHSCTs were performed in 29 centers, and 33.8% of patients relapsed. Among them, 319 (12.4%) were considered to have LR, representing an incidence of 4.2% for the entire cohort. The full dataset was available for 290 patients, including 250 (86.2%) with acute myeloid leukemia and 40 (13.8%) with acute lymphoid leukemia. The median interval from AHSCT to LR was 38.2 months (interquartile range [IQR], 29.2 to 49.7 months), and 27.2% of the patients had extramedullary involvement at LR (17.2% exclusively and 10% associated with medullary involvement). One-third of the patients had persistent full donor chimerism at LR. Median overall survival (OS) after LR was 19.9 months (IQR, 5.6 to 46.4 months). The most common salvage therapy was induction regimen (55.5%), with complete remission (CR) obtained in 50.7% of cases. Ninety-four patients (38.5%) underwent a second AHSCT, with a median OS of 20.4 months (IQR, 7.1 to 49.1 months). Nonrelapse mortality after second AHSCT was 18.2%. The Cox model identified the following factors as associated with delay of LR: disease status not in first CR at first HSCT (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.04 to 1.64; P = .02) and the use of post-transplantation cyclophosphamide (OR, 2.23; 95% CI, 1.21 to 4.14; P = .01). Chronic GVHD appeared to be a protective factor (OR, .64; 95% CI, .42 to .96; P = .04). The prognosis of LR is better than in early relapse, with a median OS after LR of 19.9 months. Salvage therapy associated with a second AHSCT improves outcome and is feasible, without creating excess toxicity

“Our femininity as a weapon”:Ethnography of the Antigones, a far-right women’s movement in contemporary France.

This article studies the Antigones, a women's movement created in 2013 in the wake of the French mobilizations against same-sex marriage. Affiliated to right and extreme right-wing movements - and especially to nativist, traditionalist Catholic or nationalistic fringes - the Antigones have been categorized as anti-feminist, owing to their promotion of the heterosexual family and of a differentialist conception of gender. An ethnography of the Antigones three years after the group's foundation gives the opportunity to highlight other less visible features of the activists' commitments and discourses. Militants seek to lay the ground for a feminism that enables them to articulate conflicting aspirations: on the one hand a commitment to women's emancipation, and on the other hand their attachment to political, religious and moral values, resulting from their socialization through familial, educational and political experiences. As a result, they advocate tackling issues related to sexuality in the light of an anti-capitalist, differentialist and spiritual definition of women that keeps theological or doctrinal arguments at bay

Timing of citizenship acquisition and immigrants’ children educational outcomes: a family fixed-effects approach

Various studies suggest a positive effect of host country citizenship on the educational outcomes of immigrants’ children. However, little is known about when and for whom citizenship matters and how much this is affected by potential endogeneity in the relation between parental citizenship acquisition and their children’s educational outcomes. Focusing on the Netherlands, this paper exploits siblings’ variation in their exposure to naturalisation in order to net out the effect of time-constant parental characteristics. Results from a linear mixed model show that children who acquire Dutch citizenship have a substantial advantage in terms of academic performance over those who are still foreign citizens, especially if they naturalised in early childhood. A novel bounding estimator that gauges the sensitivity of the estimates to omitted variable bias confirms the robustness of these results. Moreover, the effects of citizenship are concentrated among students whose parents are at a disadvantage in the labour market and housing market, shedding light on hitherto under-explored effect heterogeneity

Le féminisme comme « héritage à dépasser » : Les Antigones, un militantisme féminin à la frontière de l’espace de la cause des femmes.

This article studies the Antigones, a women’s movement created in 2013 in the wake of the French mobilizations against same-sex marriage. Affiliated to right and extreme right-wing movements - and especially to nativist, traditionalist Catholic or nationalistic fringes - the Antigones have been categorized as anti-feminist, owing to their promotion of the heterosexual family and of a differentialist conception of gender. An ethnography of the Antigones three years after the group’s foundation gives the opportunity to highlight other less visible features of the activists’ commitments and discourses. Militants seek to lay the ground for a feminism that enables them to articulate conflicting aspirations: on the one hand a commitment to women’s emancipation, and on the other hand their attachment to political, religious and moral values, resulting from their socialization through familial, educational and political experiences. As a result, they advocate tackling issues related to sexuality in the light of an anti-capitalist, differentialist and spiritual definition of women that keeps theological or doctrinal arguments at bay

The intergenerational impact of naturalisation reforms: the citizenship status of children of immigrants in the Netherlands, 1995–2016

Published online: 04 February 2020For many children of immigrants to Europe, being born in a European country does not give them rights of citizenship. To acquire citizenship of the country of their birth, they typically rely on their parents’ naturalisation. While many European countries have tightened requirements for citizenship over recent decades, the impact of new regulations on immigrants’ children propensity to naturalise has gone largely unexplored. This paper analyses the impact of two restrictive legislative changes in the Netherlands: the re-introduction of a dual citizenship restriction in 1997, and the introduction of civic integration requirements in 2003. Using register data and event-history models, we analyse the acquisition of Dutch citizenship by children born in the Netherlands between 1995 and 2010 to immigrant parents. We find that the dual citizenship restriction puts families off naturalising while mandatory civic integration sees them postpone naturalisation. The intergenerational impact of naturalisation reforms is also reflected in the extent to which both parents are involved in the naturalisation process. Children eligible under stricter requirements are more likely to naturalise with one parent instead of both, in contrast to earlier eligibility cohorts. These findings shed light on key family dynamics in the acquisition of host country citizenship