A Resolution Analysis of Two Geophysical Imaging Methods For Characterizing and Monitoring Hydrologic Conditions in the Vadose Zone

The objective of this research project was to analyze the resolution of two geophysical imaging techniques: electrical resistivity tomography (ERT) and cross-borehole ground penetrating radar (XBGPR) for monitoring subsurface flow and transport processes within the vadose zone. This was accomplished through a coupled approach involving very fine-scale unsaturated flow forward modeling, conversion of the resultant flow and solute fields to geophysical property models, forward geophysical modeling using the property model obtained from the last step to obtain synthetic geophysical data, and finally inversion of this synthetic data. These geophysical property models were then compared to those derived from the conversion of the hydrologic forward modeling to provide an understanding of the resolution and limitations of the geophysical techniques

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions

In our continuing effort to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the structure-activity relationship (SAR) of alkyl substituted pyrrole fused at the 7,8-positions. A methyl group substituted at the nitrogen in the 7-position of the pyrrole ring led to a series of potent apoptosis inducers with potency in the low nanomolar range. These compounds were also found to be low nanomolar or subnanomolar inhibitors of cell growth, and they inhibited tubulin polymerization, indicating that methylation of the 7-position nitrogen does not change the mechanism of action of these chromenes. Compound 2d was identified as a highly potent apoptosis inducer with an EC50 value of 2 nM and a highly potent inhibitor of cell growth with a GI50 value of 0.3 nM in T47D cells