Contrucción y ensayo de colectores solares calentadores de aire utilizando materiales no habituales

Se presentan los resultados del diseño, construcción, ensayo y comparación de colectores solares para calentamiento de aire de bajo costo. Se compararon seis prototipos con un área expuesta nominal de 1 m². Las superficies absorbedoras han sido construidas con materiales no habituales y/o reciclados: chapa ondulada de acero galvanizado, chapa plana galvanizada perforada, latas de aluminio, viruta metálica. La cubierta, de film de polietileno transparente de 200 micrones. Se presentan las ventajas y desventajas con relación al diseño, los procesos y factibilidades constructivas acordes al medio social en el cuál serán transferidos (comunidad de escasos recursos). Se analizan los niveles térmicos alcanzados en el aire de entrada y salida de cada colector y en un recinto de 1 m3 adosado a cada uno de ellos como área a climatizar. La medición se realizó en los meses de julio y agosto de 2010. Como conclusiones se identifican los sistemas que han presentado las mejores prestaciones.This work exposes the results of designing, construction, testing and comparison of low cost air heating solar collector. Six prototypes were compared with a nominal surface area of 1 m2 . Absorber surfaces have been built with unusual and / or recycled materials: corrugated metal, galvanized steel, aluminum cans, metal shavings. The cover is a 200 microns transparent polyethylene sheet. Advantages and disadvantages related to designing, processes and feasibility constructive related to social location in which will be transferred, is presented. Achieved thermal levels from input and output air collector and a 1 m3 air container connected to each of them, were analyzed. Measurement was realized in July and August 2010. As a result, systems that have presented the best performance were identified.Fil: San Juan, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Arquitectura y Urbanismo. Instituto de Inv y Politica del Ambiente Construido; ArgentinaFil: Viegas, Graciela Melisa. Universidad Nacional de la Plata. Facultad de Arquitectura y Urbanismo. Instituto de Inv y Politica del Ambiente Construido; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Discoli, Carlos Alberto. Universidad Nacional de la Plata. Facultad de Arquitectura y Urbanismo. Instituto de Inv y Politica del Ambiente Construido; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, Federico. Universidad Nacional de la Plata. Facultad de Arquitectura y Urbanismo. Instituto de Inv y Politica del Ambiente Construido; ArgentinaFil: Lamonica, Martin. Universidad Nacional de la Plata. Facultad de Arquitectura y Urbanismo. Instituto de Inv y Politica del Ambiente Construido; ArgentinaFil: Ruótolo, Carla. No especifica;Fil: Güimil, Ana. No especifica

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe form of the disease. In this study, to investigate the effects of MDS on human progenitor subtypes that control neuronal output and influence brain topology, we analyzed cerebral organoids derived from control and MDS-induced pluripotent stem cells (iPSCs) using time-lapse imaging, immunostaining, and single-cell RNA sequencing. We saw a cell migration defect that was rescued when we corrected the MDS causative chromosomal deletion and severe apoptosis of the founder neuroepithelial stem cells, accompanied by increased horizontal cell divisions. We also identified a mitotic defect in outer radial glia, a progenitor subtype that is largely absent from lissencephalic rodents but critical for human neocortical expansion. Our study, therefore, deepens our understanding of MDS cellular pathogenesis and highlights the broad utility of cerebral organoids for modeling human neurodevelopmental disorders

Technology-enabled person-centered mental health services reform: strategy for implementation science

Health information technologies are being rapidly developed to improve the delivery of mental health care; however, a range of facilitators, barriers, and contextual conditions can impact the adoption and sustainment of these solutions. An implementation science protocol supports researchers to achieve primary effectiveness goals in relation to mental health services reform and aids in the optimization of implementation processes to promote quality health care, prolonging sustainability.The aim of this paper is to describe our implementation science protocol, which serves as a foundation by which to systematically guide the implementation of technology-enabled solutions in traditional face-to-face and Web-based mental health services, allowing for revisions over time on the basis of retrospective review and constructive feedback from the services in which the technology-enabled solutions are implemented.Our implementation science protocol comprises four phases. The primary objective of the scoping and feasibility phase (Phase 1) is to determine the alignment between the service partner and the quality improvement goals supported by the technology-enabled solution. This is followed by Phase 2, the local co-design and preimplementation phase, which aims to utilize co-design methodologies, including service pathway modelling, participatory design, and user (acceptance) testing, to determine how the solutions could be used to enhance the service. In Phase 3, implementation, the accepted solution is embedded in the mental health service to achieve better outcomes for consumers and their families as well as health professionals and service managers. Using iterative evaluative processes throughout Phase 3, the solution is continuously developed, designed, and refined during implementation to adapt to the changing needs of the stakeholders, including consumers with lived experience and their families as well as the service. Thus, the primary outcome of Phase 3 is the optimized technology-enabled solution that can be maintained in a service during the sustainment and scalability phase (Phase 4) for the purposes of mental health services reform.Funding for the protocol was provided by the Australian Government Department of Health in June of 2017 for a period of 3 years. At the time of this publication, the protocol had been initiated in 11 services, serving three populations, all of which are currently operating in Phase 3. The first results are expected to be submitted for publication in 2020.With the aim of improving mental health service quality, our implementation science protocol aids in the identification of factors that predict the likelihood of implementation success, as well as the development of strategies to proactively mitigate potential barriers to achieve better implementation outcomes. Putting in place a theoretically sound implementation science protocol is essential to facilitate the uptake of novel technology-enabled solutions and evidence-based practices into routine clinical practice for the purposes of improved outcomes

Open Standards, Open Source, and Open Innovation: Harnessing the Benefits of Openness

Digitization of information and the growth of the Internet have profoundly expanded the capacity for openness, which can be viewed largely as a function of the accessibility and responsiveness (meaning the ability of anyone to make modifications) of a work or process. In this report, the Digital Connections Council of the Committee for Economic Development (CED) studies the impact of three manifestations of openness in order to gauge the importance of openness, and to determine whether public policy should encourage it, restrict it, or be neutral

In Vivo Treatment Sensitivity Testing With Positron Emission Tomography/Computed Tomography After One Cycle of Chemotherapy for Hodgkin Lymphoma

Negative [(18)F]fluorodeoxyglucose (FDG) -positron emission tomography (PET)/computed tomography (CT) after two cycles of chemotherapy indicates a favorable prognosis in Hodgkin lymphoma (HL). We hypothesized that the negative predictive value would be even higher in patients responding rapidly enough to be PET negative after one cycle. This prospective study aimed to assess the prognostic value of PET after one cycle of chemotherapy in HL and to assess the dynamics of FDG uptake after one cycle (PET1) and after two cycles (PET2).All PET scans were read by two blinded, independent reviewers in different countries, according to the Deauville five-point scale. The main end point was progression-free survival (PFS) after 2 years.A total of 126 patients were included, and all had PET1; 89 patients had both PET1 and PET2. The prognostic value of PET1 was statistically significant with respect to both PFS and overall survival. Two-year PFS for PET1-negative and PET1-positive patients was 94.1% and 40.8%, respectively. Among those with both PET1 and PET2, 2-year PFS was 98.3% and 38.5% for PET1-negative and PET1-positive patients and 90.2% and 23.1% for PET2-negative and PET2-positive patients, respectively. No PET1-negative patient was PET2 positive.PET after one cycle of chemotherapy is highly prognostic in HL. No other prognostic tool identifies a group of patients with HL with a more favorable outcome than those patients with a negative PET1. In the absence of precise pretherapeutic predictive markers, PET1 is the best method for response-adapted strategies designed to select patients for less intensive treatment